(54 nodes) Positive regulation of inflammatory response network (Austrofundulus limnaeus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106522953	CCAAT/enhancer-binding protein beta-like. (287 aa)
	LOC106537084	Pro-interleukin-16-like. (1355 aa)
	LOC106535600	Interleukin-1 receptor-like 1. (398 aa)
	LOC106534173	G-protein coupled receptor family C group 5 member B-like. (422 aa)
	LOC106533471	Caspase-1-like; Belongs to the peptidase C14A family. (296 aa)
	ccdc142	Coiled-coil domain-containing protein 142. (1027 aa)
	pycard	Apoptosis-associated speck-like protein containing a CARD. (192 aa)
	vamp8	Vesicle-associated membrane protein 8. (122 aa)
	LOC106532061	Uncharacterized protein LOC106532061. (205 aa)
	kars	Lysine--tRNA ligase. (601 aa)
	LOC106530943	Zona pellucida sperm-binding protein 3-like. (396 aa)
	LOC106530826	Sorting nexin-4-like. (438 aa)
	nmi	N-myc-interactor. (380 aa)
	gpr4	G-protein coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	LOC106530082	Free fatty acid receptor 3-like. (350 aa)
	LOC106530070	Free fatty acid receptor 2-like. (301 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily member 1A. (389 aa)
	setd4	SET domain-containing protein 4. (449 aa)
	LOC106527443	Sorting nexin-4-like. (449 aa)
	serpine1	Plasminogen activator inhibitor 1; Belongs to the serpin family. (391 aa)
	LOC106526335	NF-kappa-B inhibitor alpha-like. (307 aa)
	LOC106526321	Galectin. (132 aa)
	LOC106526310	Galectin. (139 aa)
	LOC106526255	C2 calcium-dependent domain-containing protein 4C-like. (427 aa)
	lrrk2	Leucine-rich repeat serine/threonine-protein kinase 2. (2528 aa)
	LOC106525902	Interleukin-17 receptor A-like. (792 aa)
	LOC106525490	Interleukin-17 receptor A-like. (466 aa)
	ifi35	Interferon-induced 35 kDa protein. (372 aa)
	LOC106524427	Protein FAM19A2-like. (128 aa)
	LOC106523066	Free fatty acid receptor 2-like isoform X1. (344 aa)
	LOC106522883	NF-kappa-B inhibitor zeta-like. (429 aa)
	LOC106522480	Galectin. (127 aa)
	LOC106522035	Vesicle-associated membrane protein 8-like isoform X1. (117 aa)
	napepld	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D. (401 aa)
	c2cd4c	C2 calcium-dependent domain-containing protein 4C. (421 aa)
	gpr68	Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
	pdcd4	Programmed cell death protein 4. (474 aa)
	LOC106520692	Galectin. (135 aa)
	LOC106520269	Zona pellucida sperm-binding protein 3-like. (435 aa)
	LOC106519401	Caspase-1-like; Belongs to the peptidase C14A family. (386 aa)
	gprc5b	G-protein coupled receptor family C group 5 member B isoform X1. (532 aa)
	tnfrsf11a	Tumor necrosis factor receptor superfamily member 11A. (647 aa)
	ctsc	Dipeptidyl peptidase 1; Belongs to the peptidase C1 family. (455 aa)
	LOC106517047	Programmed cell death protein 4-like. (467 aa)
	ptgs2	Prostaglandin G/H synthase 2. (608 aa)
	LOC106516346	Signal-transducing adaptor protein 1-like. (364 aa)
	LOC106516312	Prostaglandin E2 receptor EP4 subtype-like. (449 aa)
	tnip1	TNFAIP3-interacting protein 1. (630 aa)
	LOC106514270	C2 calcium-dependent domain-containing protein 4C-like isoform X1. (448 aa)
	il6st	Interleukin-6 receptor subunit beta isoform X1. (875 aa)
	LOC106513689	Prostaglandin E2 receptor EP4 subtype-like; Belongs to the G-protein coupled receptor 1 family. (448 aa)
	LOC106511186	Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family. (263 aa)
	LOC106511025	NF-kappa-B inhibitor alpha-like. (318 aa)
	il1b	Interleukin-1. (246 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106511025	LOC106522883	A0A2I4AID5	A0A2I4BV19	NF-kappa-B inhibitor alpha-like.	NF-kappa-B inhibitor zeta-like.	0.476
LOC106511025	LOC106526335	A0A2I4AID5	A0A2I4C8S5	NF-kappa-B inhibitor alpha-like.	NF-kappa-B inhibitor alpha-like.	0.904
LOC106511025	il1b	A0A2I4AID5	A0A2I4AHI5	NF-kappa-B inhibitor alpha-like.	Interleukin-1.	0.585
LOC106511025	ptgs2	A0A2I4AID5	A0A2I4B512	NF-kappa-B inhibitor alpha-like.	Prostaglandin G/H synthase 2.	0.416
LOC106511186	il1b	A0A2I4AIS2	A0A2I4AHI5	Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family.	Interleukin-1.	0.563
LOC106511186	tnfrsf11a	A0A2I4AIS2	A0A2I4B840	Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 11A.	0.998
LOC106511186	tnfrsf1a	A0A2I4AIS2	A0A2I4CIY9	Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 1A.	0.467
LOC106513689	ptgs2	A0A2I4ARH0	A0A2I4B512	Prostaglandin E2 receptor EP4 subtype-like; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin G/H synthase 2.	0.422
LOC106516312	ptgs2	A0A2I4B2X2	A0A2I4B512	Prostaglandin E2 receptor EP4 subtype-like.	Prostaglandin G/H synthase 2.	0.422
LOC106519401	LOC106533471	A0A2I4BFK1	A0A2I4CZ31	Caspase-1-like; Belongs to the peptidase C14A family.	Caspase-1-like; Belongs to the peptidase C14A family.	0.903
LOC106519401	il1b	A0A2I4BFK1	A0A2I4AHI5	Caspase-1-like; Belongs to the peptidase C14A family.	Interleukin-1.	0.981
LOC106519401	pycard	A0A2I4BFK1	A0A2I4CW30	Caspase-1-like; Belongs to the peptidase C14A family.	Apoptosis-associated speck-like protein containing a CARD.	0.987
LOC106520692	LOC106534173	A0A2I4BKU5	A0A2I4D1T6	Galectin.	G-protein coupled receptor family C group 5 member B-like.	0.465
LOC106520692	gprc5b	A0A2I4BKU5	A0A2I4BCU7	Galectin.	G-protein coupled receptor family C group 5 member B isoform X1.	0.465
LOC106522035	vamp8	A0A2I4BRF1	A0A2I4CUU8	Vesicle-associated membrane protein 8-like isoform X1.	Vesicle-associated membrane protein 8.	0.901
LOC106522883	LOC106511025	A0A2I4BV19	A0A2I4AID5	NF-kappa-B inhibitor zeta-like.	NF-kappa-B inhibitor alpha-like.	0.476
LOC106522883	LOC106526335	A0A2I4BV19	A0A2I4C8S5	NF-kappa-B inhibitor zeta-like.	NF-kappa-B inhibitor alpha-like.	0.476
LOC106522883	il1b	A0A2I4BV19	A0A2I4AHI5	NF-kappa-B inhibitor zeta-like.	Interleukin-1.	0.410
LOC106525490	LOC106525902	A0A2I4C5D7	A0A2I4C6W4	Interleukin-17 receptor A-like.	Interleukin-17 receptor A-like.	0.904
LOC106525490	il1b	A0A2I4C5D7	A0A2I4AHI5	Interleukin-17 receptor A-like.	Interleukin-1.	0.406