(23 nodes) Multicellular organismal water homeostasis network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106513888	Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (332 aa)
	LOC106510847	Serum response factor-like. (385 aa)
	wfs1	Wolframin. (960 aa)
	stard7	stAR-related lipid transfer protein 7, mitochondrial. (407 aa)
	LOC106516763	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family. (276 aa)
	LOC106518122	Transmembrane protein 79-like. (425 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1503 aa)
	fa2h	Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (385 aa)
	srf	Serum response factor isoform X1. (485 aa)
	LOC106525405	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (597 aa)
	bves	Blood vessel epicardial substance. (361 aa)
	LOC106530404	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (208 aa)
	ext2	Exostosin-2; Belongs to the glycosyltransferase 47 family. (719 aa)
	LOC106531114	Wolframin-like isoform X1. (988 aa)
	LOC106533171	Aquaporin FA-CHIP-like; Belongs to the MIP/aquaporin (TC 1.A.8) family. (280 aa)
	LOC106533179	Aquaporin-1-like; Belongs to the MIP/aquaporin (TC 1.A.8) family. (264 aa)
	aqp4	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (325 aa)
	LOC106534581	Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (314 aa)
	akap11	A-kinase anchor protein 11. (1864 aa)
	kdf1	Keratinocyte differentiation factor 1. (388 aa)
	LOC106535843	LOW QUALITY PROTEIN: keratinocyte differentiation factor 1-like. (347 aa)
	ugcg	Ceramide glucosyltransferase. (394 aa)
	LOC106536703	Serum response factor-like. (519 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106510847	LOC106536703	A0A2I4AHR9	A0A2I4DB71	Serum response factor-like.	Serum response factor-like.	0.902
LOC106510847	srf	A0A2I4AHR9	A0A2I4BS82	Serum response factor-like.	Serum response factor isoform X1.	0.901
LOC106513888	LOC106534581	A0A2I4ASC7	A0A2I4D3D0	Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...]	Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...]	0.901
LOC106516763	LOC106533171	A0A2I4B4Q1	A0A2I4CXZ6	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin FA-CHIP-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.465
LOC106516763	LOC106533179	A0A2I4B4Q1	A0A2I4CXZ7	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-1-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.473
LOC106516763	cftr	A0A2I4B4Q1	A0A2I4BDB4	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.422
LOC106531114	wfs1	A0A2I4CQS0	A0A2I4AIH0	Wolframin-like isoform X1.	Wolframin.	0.902
LOC106533171	LOC106516763	A0A2I4CXZ6	A0A2I4B4Q1	Aquaporin FA-CHIP-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.465
LOC106533171	aqp4	A0A2I4CXZ6	A0A2I4D1C1	Aquaporin FA-CHIP-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.450
LOC106533179	LOC106516763	A0A2I4CXZ7	A0A2I4B4Q1	Aquaporin-1-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.473
LOC106533179	aqp4	A0A2I4CXZ7	A0A2I4D1C1	Aquaporin-1-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.452
LOC106534581	LOC106513888	A0A2I4D3D0	A0A2I4ASC7	Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...]	Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...]	0.901
LOC106536703	LOC106510847	A0A2I4DB71	A0A2I4AHR9	Serum response factor-like.	Serum response factor-like.	0.902
LOC106536703	srf	A0A2I4DB71	A0A2I4BS82	Serum response factor-like.	Serum response factor isoform X1.	0.904
aqp4	LOC106533171	A0A2I4D1C1	A0A2I4CXZ6	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin FA-CHIP-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.450
aqp4	LOC106533179	A0A2I4D1C1	A0A2I4CXZ7	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-1-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.452
aqp4	cftr	A0A2I4D1C1	A0A2I4BDB4	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.422
cftr	LOC106516763	A0A2I4BDB4	A0A2I4B4Q1	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Aquaporin-4-like; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.422
cftr	aqp4	A0A2I4BDB4	A0A2I4D1C1	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.422
fa2h	ugcg	A0A2I4BIT3	A0A2I4D9I7	Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...]	Ceramide glucosyltransferase.	0.456