(23 nodes) Lung morphogenesis network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	srf	Serum response factor isoform X1. (485 aa)
	LOC106537362	Laminin subunit alpha-1-like. (2416 aa)
	LOC106536703	Serum response factor-like. (519 aa)
	LOC106535758	Laminin subunit alpha-1-like. (2416 aa)
	LOC106535196	Dystroglycan-like. (910 aa)
	LOC106533483	Cathepsin Z-like; Belongs to the peptidase C1 family. (268 aa)
	hps1	Hermansky-Pudlak syndrome 1 protein. (660 aa)
	tcf21	Transcription factor 21. (194 aa)
	stk40	Serine/threonine-protein kinase 40. (436 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
	LOC106520852	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (557 aa)
	LOC106520732	Cathepsin Z-like; Belongs to the peptidase C1 family. (214 aa)
	LOC106520731	Cathepsin Z-like; Belongs to the peptidase C1 family. (300 aa)
	LOC106519273	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
	LOC106518967	Pro-cathepsin H-like; Belongs to the peptidase C1 family. (305 aa)
	LOC106518866	Protein sprouty homolog 2-like. (336 aa)
	LOC106517635	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
	hhip	Hedgehog-interacting protein. (706 aa)
	dlg5	Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (2053 aa)
	ctsh	Pro-cathepsin H; Belongs to the peptidase C1 family. (325 aa)
	ctsz	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	dag1	Dystroglycan. (896 aa)
	LOC106510847	Serum response factor-like. (385 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106510847	LOC106536703	A0A2I4AHR9	A0A2I4DB71	Serum response factor-like.	Serum response factor-like.	0.902
LOC106510847	srf	A0A2I4AHR9	A0A2I4BS82	Serum response factor-like.	Serum response factor isoform X1.	0.901
LOC106519273	LOC106520852	A0A2I4BEZ6	A0A2I4BLH0	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.902
LOC106520852	LOC106519273	A0A2I4BLH0	A0A2I4BEZ6	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.902
LOC106535196	LOC106535758	A0A2I4D5R8	A0A2I4D7S8	Dystroglycan-like.	Laminin subunit alpha-1-like.	0.713
LOC106535196	LOC106537362	A0A2I4D5R8	A0A2I4DD81	Dystroglycan-like.	Laminin subunit alpha-1-like.	0.713
LOC106535196	dag1	A0A2I4D5R8	A0A2I4AI45	Dystroglycan-like.	Dystroglycan.	0.902
LOC106535758	LOC106535196	A0A2I4D7S8	A0A2I4D5R8	Laminin subunit alpha-1-like.	Dystroglycan-like.	0.713
LOC106535758	dag1	A0A2I4D7S8	A0A2I4AI45	Laminin subunit alpha-1-like.	Dystroglycan.	0.713
LOC106536703	LOC106510847	A0A2I4DB71	A0A2I4AHR9	Serum response factor-like.	Serum response factor-like.	0.902
LOC106536703	srf	A0A2I4DB71	A0A2I4BS82	Serum response factor-like.	Serum response factor isoform X1.	0.904
LOC106537362	LOC106535196	A0A2I4DD81	A0A2I4D5R8	Laminin subunit alpha-1-like.	Dystroglycan-like.	0.713
LOC106537362	dag1	A0A2I4DD81	A0A2I4AI45	Laminin subunit alpha-1-like.	Dystroglycan.	0.713
dag1	LOC106535196	A0A2I4AI45	A0A2I4D5R8	Dystroglycan.	Dystroglycan-like.	0.902
dag1	LOC106535758	A0A2I4AI45	A0A2I4D7S8	Dystroglycan.	Laminin subunit alpha-1-like.	0.713
dag1	LOC106537362	A0A2I4AI45	A0A2I4DD81	Dystroglycan.	Laminin subunit alpha-1-like.	0.713
srf	LOC106510847	A0A2I4BS82	A0A2I4AHR9	Serum response factor isoform X1.	Serum response factor-like.	0.901
srf	LOC106536703	A0A2I4BS82	A0A2I4DB71	Serum response factor isoform X1.	Serum response factor-like.	0.904