(54 nodes) Positive regulation of small molecule metabolic process network (Austrofundulus limnaeus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ddb1	DNA damage-binding protein 1. (1140 aa)
	podn	Podocan. (593 aa)
	apoe	Apolipoprotein E. (251 aa)
	LOC106530689	Non-specific serine/threonine protein kinase. (557 aa)
	rusc1	RUN and SH3 domain-containing protein 1. (1814 aa)
	LOC106532110	Guanylyl cyclase-activating protein 1-like. (189 aa)
	LOC106533066	5-hydroxytryptamine receptor 2A-like. (302 aa)
	LOC106533492	acyl-CoA:lysophosphatidylglycerol acyltransferase 1-like. (85 aa)
	LOC106533540	Sterol regulatory element-binding protein 1-like. (287 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (158 aa)
	dab2	Disabled homolog 2 isoform X1. (739 aa)
	pth	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (113 aa)
	LOC106535459	Sterol regulatory element-binding protein cleavage-activating protein-like. (1274 aa)
	abcg1	ATP-binding cassette sub-family G member 1. (685 aa)
	mlycd	malonyl-CoA decarboxylase, mitochondrial. (504 aa)
	il1b	Interleukin-1. (246 aa)
	aaed1	Thioredoxin-like protein AAED1. (226 aa)
	pparg	Peroxisome proliferator-activated receptor gamma isoform X1. (554 aa)
	guca1a	Guanylyl cyclase-activating protein 1. (189 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (1002 aa)
	nr1h4	Bile acid receptor isoform X1. (493 aa)
	igf2	Insulin-like growth factor II. (215 aa)
	abcg4	ATP-binding cassette sub-family G member 4. (641 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (573 aa)
	ncs1	Neuronal calcium sensor 1 isoform X1. (204 aa)
	ptgs2	Prostaglandin G/H synthase 2. (608 aa)
	LOC106518287	Guanylin-like. (108 aa)
	LOC106518288	Guanylin-like. (108 aa)
	bend3	BEN domain-containing protein 3. (800 aa)
	LOC106518912	Bile acid receptor-like isoform X1. (490 aa)
	guca1b	Guanylyl cyclase-activating protein 2. (197 aa)
	LOC106520176	P2Y purinoceptor 3-like; Belongs to the G-protein coupled receptor 1 family. (444 aa)
	srebf2	Sterol regulatory element-binding protein 2. (1175 aa)
	p2ry6	P2Y purinoceptor 6. (353 aa)
	ppara	Peroxisome proliferator-activated receptor alpha. (477 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (576 aa)
	srebf1	Sterol regulatory element-binding protein 1. (1170 aa)
	lpgat1	acyl-CoA:lysophosphatidylglycerol acyltransferase 1. (345 aa)
	LOC106523408	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (177 aa)
	nr1h3	Oxysterols receptor LXR-alpha. (453 aa)
	LOC106523750	Apolipoprotein Eb-like. (265 aa)
	pid1	PTB-containing, cubilin and LRP1-interacting protein. (225 aa)
	LOC106524485	CD48 antigen-like isoform X1. (300 aa)
	LOC106524682	Nuclear receptor subfamily 1 group D member 1-like. (574 aa)
	clybl	Citrate lyase subunit beta-like protein, mitochondrial. (275 aa)
	LOC106524858	ATP-binding cassette sub-family D member 2-like isoform X1. (736 aa)
	ppard	Peroxisome proliferator-activated receptor delta. (495 aa)
	sirt1	NAD-dependent protein deacetylase sirtuin-1. (690 aa)
	zbtb20	Zinc finger and BTB domain-containing protein 20. (678 aa)
	scap	Sterol regulatory element-binding protein cleavage-activating protein. (1360 aa)
	LOC106526977	P2Y purinoceptor 3-like; Belongs to the G-protein coupled receptor 1 family. (475 aa)
	LOC106528070	Nuclear receptor subfamily 1 group D member 1-like. (570 aa)
	LOC106528115	Citrate lyase subunit beta-like protein, mitochondrial. (111 aa)
	LOC106528190	Peroxisome proliferator-activated receptor alpha-like. (469 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106518912	ppargc1a	A0A2I4BDI3	A0A2I4AWE7	Bile acid receptor-like isoform X1.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	0.803
LOC106523750	il1b	A0A2I4BYB0	A0A2I4AHI5	Apolipoprotein Eb-like.	Interleukin-1.	0.511
LOC106523750	nr1h3	A0A2I4BYB0	A0A2I4BXI8	Apolipoprotein Eb-like.	Oxysterols receptor LXR-alpha.	0.416
LOC106528190	nr1h3	A0A2I4CFJ1	A0A2I4BXI8	Peroxisome proliferator-activated receptor alpha-like.	Oxysterols receptor LXR-alpha.	0.508
LOC106528190	ppara	A0A2I4CFJ1	A0A2I4BQJ2	Peroxisome proliferator-activated receptor alpha-like.	Peroxisome proliferator-activated receptor alpha.	0.901
LOC106528190	ppargc1a	A0A2I4CFJ1	A0A2I4AWE7	Peroxisome proliferator-activated receptor alpha-like.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	0.858
LOC106528190	sirt1	A0A2I4CFJ1	A0A2I4C5T8	Peroxisome proliferator-activated receptor alpha-like.	NAD-dependent protein deacetylase sirtuin-1.	0.492
LOC106530689	prkaa1	A0A2I4CPB4	A0A2I4B2W1	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.916
LOC106530689	sirt1	A0A2I4CPB4	A0A2I4C5T8	Non-specific serine/threonine protein kinase.	NAD-dependent protein deacetylase sirtuin-1.	0.499
LOC106532110	guca1a	A0A2I4CU97	A0A2I4AW54	Guanylyl cyclase-activating protein 1-like.	Guanylyl cyclase-activating protein 1.	0.570
LOC106533540	LOC106535459	A0A2I4CZB4	A0A2I4D6Q3	Sterol regulatory element-binding protein 1-like.	Sterol regulatory element-binding protein cleavage-activating protein-like.	0.851
LOC106533540	nr1h3	A0A2I4CZB4	A0A2I4BXI8	Sterol regulatory element-binding protein 1-like.	Oxysterols receptor LXR-alpha.	0.427
LOC106533540	pparg	A0A2I4CZB4	A0A2I4AS31	Sterol regulatory element-binding protein 1-like.	Peroxisome proliferator-activated receptor gamma isoform X1.	0.493
LOC106533540	scap	A0A2I4CZB4	A0A2I4CA36	Sterol regulatory element-binding protein 1-like.	Sterol regulatory element-binding protein cleavage-activating protein.	0.851
LOC106533540	sirt1	A0A2I4CZB4	A0A2I4C5T8	Sterol regulatory element-binding protein 1-like.	NAD-dependent protein deacetylase sirtuin-1.	0.447
LOC106535459	LOC106533540	A0A2I4D6Q3	A0A2I4CZB4	Sterol regulatory element-binding protein cleavage-activating protein-like.	Sterol regulatory element-binding protein 1-like.	0.851
LOC106535459	srebf1	A0A2I4D6Q3	A0A2I4BRI0	Sterol regulatory element-binding protein cleavage-activating protein-like.	Sterol regulatory element-binding protein 1.	0.851
LOC106535459	srebf2	A0A2I4D6Q3	A0A2I4BKV7	Sterol regulatory element-binding protein cleavage-activating protein-like.	Sterol regulatory element-binding protein 2.	0.851
abcg1	nr1h3	A0A2I4D7R2	A0A2I4BXI8	ATP-binding cassette sub-family G member 1.	Oxysterols receptor LXR-alpha.	0.578
abcg1	srebf2	A0A2I4D7R2	A0A2I4BKV7	ATP-binding cassette sub-family G member 1.	Sterol regulatory element-binding protein 2.	0.497