(41 nodes) Regulation of protein processing network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hpn	Serine protease hepsin isoform X1; Belongs to the peptidase S1 family. (490 aa)
	prkacb	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (380 aa)
	spon1	Spondin-1. (806 aa)
	ctsz	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	plgrkt	Plasminogen receptor (KT). (149 aa)
	ldlrad3	Low-density lipoprotein receptor class A domain-containing protein 3. (356 aa)
	LOC106517220	Interleukin-1 receptor type 2-like. (418 aa)
	chac1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (196 aa)
	bag2	BAG family molecular chaperone regulator 2. (208 aa)
	LOC106520088	cystatin-F-like. (155 aa)
	LOC106520180	Alpha-2-antiplasmin-like; Belongs to the serpin family. (480 aa)
	LOC106520204	Spondin-1-like. (773 aa)
	LOC106520325	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (206 aa)
	LOC106520731	Cathepsin Z-like; Belongs to the peptidase C1 family. (300 aa)
	LOC106520732	Cathepsin Z-like; Belongs to the peptidase C1 family. (214 aa)
	LOC106520847	Tetranectin-like. (201 aa)
	LOC106520880	Protein S100; Belongs to the S-100 family. (95 aa)
	lpcat3	Lysophospholipid acyltransferase 5 isoform X1; Belongs to the membrane-bound acyltransferase family. (465 aa)
	LOC106522807	Protein phosphatase 1 regulatory subunit 15A-like. (562 aa)
	cast	Calpastatin. (1015 aa)
	rnf139	E3 ubiquitin-protein ligase RNF139. (689 aa)
	LOC106525381	Growth arrest-specific protein 1-like. (268 aa)
	lrrk2	Leucine-rich repeat serine/threonine-protein kinase 2. (2528 aa)
	LOC106526233	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	bcl2l12	Bcl-2-like protein 12. (335 aa)
	serpine1	Plasminogen activator inhibitor 1; Belongs to the serpin family. (391 aa)
	LOC106527441	Golgi apparatus protein 1-like. (1144 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	clec3b	Tetranectin. (198 aa)
	cln3	Battenin. (434 aa)
	LOC106529865	Golgi apparatus protein 1-like isoform X1. (1147 aa)
	ift52	Intraflagellar transport protein 52 homolog. (433 aa)
	cntn2	Contactin-2. (308 aa)
	LOC106530483	Growth arrest-specific protein 1-like. (249 aa)
	rhbdd1	Rhomboid-related protein 4. (313 aa)
	serpine2	Glia-derived nexin isoform X1; Belongs to the serpin family. (394 aa)
	serpinf2	Alpha-2-antiplasmin isoform X1; Belongs to the serpin family. (514 aa)
	LOC106533483	Cathepsin Z-like; Belongs to the peptidase C1 family. (268 aa)
	LOC106533807	cAMP-dependent protein kinase catalytic subunit beta-like isoform X1; Belongs to the protein kinase superfamily. (354 aa)
	LOC106534469	Contactin-2-like. (1039 aa)
	LOC106534672	cAMP-dependent protein kinase catalytic subunit alpha-like; Belongs to the protein kinase superfamily. (351 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106520325	chac1	A0A2I4BJ71	A0A2I4BCC8	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.901
LOC106525381	LOC106530483	A0A2I4C4Z1	A0A2I4CNK4	Growth arrest-specific protein 1-like.	Growth arrest-specific protein 1-like.	0.906
LOC106526233	LOC106533807	A0A2I4C8E2	A0A2I4D0C5	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit beta-like isoform X1; Belongs to the protein kinase superfamily.	0.900
LOC106526233	LOC106534672	A0A2I4C8E2	A0A2I4D3L1	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit alpha-like; Belongs to the protein kinase superfamily.	0.900
LOC106526233	prkacb	A0A2I4C8E2	A0A2I4AJ99	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.900
LOC106527441	LOC106529865	A0A2I4CCR5	A0A2I4CLI2	Golgi apparatus protein 1-like.	Golgi apparatus protein 1-like isoform X1.	0.900
LOC106529865	LOC106527441	A0A2I4CLI2	A0A2I4CCR5	Golgi apparatus protein 1-like isoform X1.	Golgi apparatus protein 1-like.	0.900
LOC106530483	LOC106525381	A0A2I4CNK4	A0A2I4C4Z1	Growth arrest-specific protein 1-like.	Growth arrest-specific protein 1-like.	0.906
LOC106533807	LOC106526233	A0A2I4D0C5	A0A2I4C8E2	cAMP-dependent protein kinase catalytic subunit beta-like isoform X1; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.900
LOC106533807	LOC106534672	A0A2I4D0C5	A0A2I4D3L1	cAMP-dependent protein kinase catalytic subunit beta-like isoform X1; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit alpha-like; Belongs to the protein kinase superfamily.	0.900
LOC106533807	prkacb	A0A2I4D0C5	A0A2I4AJ99	cAMP-dependent protein kinase catalytic subunit beta-like isoform X1; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.900
LOC106534672	LOC106526233	A0A2I4D3L1	A0A2I4C8E2	cAMP-dependent protein kinase catalytic subunit alpha-like; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.900
LOC106534672	LOC106533807	A0A2I4D3L1	A0A2I4D0C5	cAMP-dependent protein kinase catalytic subunit alpha-like; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit beta-like isoform X1; Belongs to the protein kinase superfamily.	0.900
LOC106534672	prkacb	A0A2I4D3L1	A0A2I4AJ99	cAMP-dependent protein kinase catalytic subunit alpha-like; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.900
chac1	LOC106520325	A0A2I4BCC8	A0A2I4BJ71	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.901
prkacb	LOC106526233	A0A2I4AJ99	A0A2I4C8E2	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.900
prkacb	LOC106533807	A0A2I4AJ99	A0A2I4D0C5	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit beta-like isoform X1; Belongs to the protein kinase superfamily.	0.900
prkacb	LOC106534672	A0A2I4AJ99	A0A2I4D3L1	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit alpha-like; Belongs to the protein kinase superfamily.	0.900
serpine1	serpine2	A0A2I4CB05	A0A2I4CPH6	Plasminogen activator inhibitor 1; Belongs to the serpin family.	Glia-derived nexin isoform X1; Belongs to the serpin family.	0.657
serpine2	serpine1	A0A2I4CPH6	A0A2I4CB05	Glia-derived nexin isoform X1; Belongs to the serpin family.	Plasminogen activator inhibitor 1; Belongs to the serpin family.	0.657