(154 nodes) Protein modification by small protein removal network (Austrofundulus limnaeus)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	usp45	Ubiquitin carboxyl-terminal hydrolase. (808 aa)
	LOC106510885	Ubiquitin carboxyl-terminal hydrolase. (972 aa)
	LOC106511090	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L. (639 aa)
	usp13	Ubiquitin carboxyl-terminal hydrolase. (863 aa)
	fam188b	Protein FAM188B isoform X1. (680 aa)
	LOC106511882	Ubiquitin carboxyl-terminal hydrolase 11-like; Belongs to the peptidase C19 family. (262 aa)
	LOC106512533	Ubiquitin carboxyl-terminal hydrolase 8-like. (173 aa)
	senp8	Sentrin-specific protease 8. (224 aa)
	fam175b	BRISC complex subunit Abro1 isoform X1. (453 aa)
	LOC106513153	Ubiquitin thioesterase ZRANB1-like. (758 aa)
	usp12	Ubiquitin carboxyl-terminal hydrolase 12; Belongs to the peptidase C19 family. (372 aa)
	cops5	COP9 signalosome complex subunit 5. (334 aa)
	psmd14	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	uspl1	SUMO-specific isopeptidase USPL1. (1165 aa)
	LOC106514273	Ubiquitin carboxyl-terminal hydrolase 42-like; Belongs to the peptidase C19 family. (376 aa)
	otud7a	OTU domain-containing protein 7A. (956 aa)
	usp3	Ubiquitin carboxyl-terminal hydrolase. (610 aa)
	usp28	Ubiquitin carboxyl-terminal hydrolase 28; Belongs to the peptidase C19 family. (1158 aa)
	usp2	Ubiquitin carboxyl-terminal hydrolase. (404 aa)
	uimc1	BRCA1-A complex subunit RAP80 isoform X1. (946 aa)
	otud4	OTU domain-containing protein 4. (812 aa)
	LOC106514705	Proline-rich protein 2-like. (334 aa)
	LOC106514817	Ubl carboxyl-terminal hydrolase 18-like isoform X1; Belongs to the peptidase C19 family. (331 aa)
	LOC106514847	Inactive ubiquitin carboxyl-terminal hydrolase 53-like. (1022 aa)
	LOC106515272	Ubiquitin carboxyl-terminal hydrolase 43-like; Belongs to the peptidase C19 family. (1221 aa)
	desi2	Desumoylating isopeptidase 2. (212 aa)
	otud6b	OTU domain-containing protein 6B. (297 aa)
	usp20	Ubiquitin carboxyl-terminal hydrolase. (942 aa)
	taf6	Transcription initiation factor TFIID subunit 6. (637 aa)
	zranb1	Ubiquitin thioesterase ZRANB1. (708 aa)
	LOC106516634	Inactive ubiquitin carboxyl-terminal hydrolase 54-like. (1161 aa)
	babam1	BRISC and BRCA1-A complex member 1 isoform X1. (429 aa)
	LOC106516832	Uncharacterized protein LOC106516832. (708 aa)
	usp38	Ubiquitin carboxyl-terminal hydrolase 38 isoform X1; Belongs to the peptidase C19 family. (1023 aa)
	LOC106517182	Inactive ubiquitin carboxyl-terminal hydrolase 53-like isoform X1. (1006 aa)
	cyld	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (956 aa)
	LOC106517417	Ubiquitin carboxyl-terminal hydrolase 31-like; Belongs to the peptidase C19 family. (1305 aa)
	LOC106517466	Dentin sialophosphoprotein-like. (704 aa)
	LOC106517877	Ubiquitin carboxyl-terminal hydrolase 43-like; Belongs to the peptidase C19 family. (1032 aa)
	wdr48	WD repeat-containing protein 48. (677 aa)
	usp4	Ubiquitin carboxyl-terminal hydrolase. (998 aa)
	yod1	Ubiquitin thioesterase OTU1. (300 aa)
	usp40	Ubiquitin carboxyl-terminal hydrolase 40; Belongs to the peptidase C19 family. (1254 aa)
	LOC106518463	Sentrin-specific protease 2-like isoform X2. (610 aa)
	atxn7	Ataxin-7 isoform X1. (922 aa)
	supt7l	STAGA complex 65 subunit gamma. (431 aa)
	LOC106518679	Ubiquitin carboxyl-terminal hydrolase. (522 aa)
	taf5	Transcription initiation factor TFIID subunit 5. (749 aa)
	otud3	LOW QUALITY PROTEIN: OTU domain-containing protein 3. (359 aa)
	dzip1	Zinc finger protein DZIP1 isoform X1. (1194 aa)
	josd2	Josephin-2. (182 aa)
	usp16	Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. (862 aa)
	usp33	Ubiquitin carboxyl-terminal hydrolase. (920 aa)
	LOC106520807	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (309 aa)
	otud1	OTU domain-containing protein 1. (437 aa)
	cops7a	COP9 signalosome complex subunit 7a. (268 aa)
	usp5	Ubiquitin carboxyl-terminal hydrolase. (848 aa)
	atxn3	Ataxin-3 isoform X1. (356 aa)
	otub2	Ubiquitin thioesterase OTUB2. (228 aa)
	LOC106521106	Coiled-coil domain-containing protein 42 homolog. (351 aa)
	tada1	Transcriptional adapter 1. (343 aa)
	LOC106521409	Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. (228 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (716 aa)
	usp30	Ubiquitin carboxyl-terminal hydrolase. (521 aa)
	LOC106521754	Ataxin-7-like protein 1. (870 aa)
	LOC106521813	Ubiquitin carboxyl-terminal hydrolase 15-like; Belongs to the peptidase C19 family. (1032 aa)
	usp19	Ubiquitin carboxyl-terminal hydrolase 19 isoform X1. (1534 aa)
	uchl5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	spata2	Spermatogenesis-associated protein 2. (568 aa)
	josd1	Josephin-1. (257 aa)
	taf12	Transcription initiation factor TFIID subunit 12. (131 aa)
	usp39	U4/U6.U5 tri-snRNP-associated protein 2 isoform X1. (501 aa)
	usp37	Ubiquitin carboxyl-terminal hydrolase. (952 aa)
	LOC106524087	Ubiquitin carboxyl-terminal hydrolase CYLD-like. (771 aa)
	LOC106524100	Ubiquitin carboxyl-terminal hydrolase 21-like; Belongs to the peptidase C19 family. (404 aa)
	cops8	COP9 signalosome complex subunit 8. (191 aa)
	senp6	Sentrin-specific protease 6. (1057 aa)
	LOC106524453	Ubiquitin carboxyl-terminal hydrolase. (381 aa)
	LOC106524707	Sentrin-specific protease 1-like isoform X1. (727 aa)
	trrap	Transformation/transcription domain-associated protein isoform X1; Belongs to the PI3/PI4-kinase family. (3852 aa)
	LOC106525206	Ataxin-7-like protein 2. (754 aa)
	gps1	COP9 signalosome complex subunit 1. (487 aa)
	cops6	COP9 signalosome complex subunit 6. (316 aa)
	stambp	STAM-binding protein. (430 aa)
	usp54	Inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X1. (1107 aa)
	sf3b5	Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
	usp49	Ubiquitin carboxyl-terminal hydrolase. (673 aa)
	LOC106537161	Ubiquitin carboxyl-terminal hydrolase 43-like; Belongs to the peptidase C19 family. (686 aa)
	taf10	Transcription initiation factor TFIID subunit 10. (186 aa)
	uchl1	Ubiquitin carboxyl-terminal hydrolase. (219 aa)
	senp7	Sentrin-specific protease 7 isoform X1. (822 aa)
	LOC106526415	Ubiquitin carboxyl-terminal hydrolase 35-like; Belongs to the peptidase C19 family. (167 aa)
	LOC106526436	Ubiquitin carboxyl-terminal hydrolase 64E-like isoform X1; Belongs to the peptidase C19 family. (515 aa)
	LOC106526625	Ribonuclease ZC3H12A-like. (593 aa)
	LOC106527064	Ubiquitin carboxyl-terminal hydrolase CYLD-like. (991 aa)
	LOC106527117	Ubiquitin carboxyl-terminal hydrolase. (506 aa)
	LOC106527146	Uncharacterized protein LOC106527146. (1048 aa)
	atxn7l3	Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. (356 aa)
	otub1	Ubiquitin thioesterase. (288 aa)
	mettl12	Methyltransferase-like protein 12, mitochondrial. (255 aa)
	uchl3	Ubiquitin carboxyl-terminal hydrolase. (232 aa)
	stambpl1	AMSH-like protease. (454 aa)
	senp5	Sentrin-specific protease 5 isoform X1. (593 aa)
	usp36	Ubiquitin carboxyl-terminal hydrolase 36; Belongs to the peptidase C19 family. (1149 aa)
	LOC106528649	Ubiquitin carboxyl-terminal hydrolase 31-like; Belongs to the peptidase C19 family. (1290 aa)
	supt3h	Transcription initiation protein SPT3 homolog. (345 aa)
	eny2	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...] (96 aa)
	fam188a	Protein FAM188A. (454 aa)
	LOC106529676	Uncharacterized protein LOC106529676. (373 aa)
	fam63a	Protein FAM63A. (582 aa)
	LOC106530140	Desumoylating isopeptidase 2-like isoform X2. (197 aa)
	usp34	Ubiquitin carboxyl-terminal hydrolase 34; Belongs to the peptidase C19 family. (3647 aa)
	usp50	Ubiquitin carboxyl-terminal hydrolase. (766 aa)
	usp8	Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1070 aa)
	vcpip1	Deubiquitinating protein VCIP135. (1170 aa)
	usp47	Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1388 aa)
	taf5l	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L. (600 aa)
	LOC106531363	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L. (369 aa)
	usp10	Ubiquitin carboxyl-terminal hydrolase. (876 aa)
	fam63b	Protein FAM63B. (652 aa)
	usp9x	Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2609 aa)
	mysm1	Histone H2A deubiquitinase MYSM1 isoform X1. (815 aa)
	brcc3	Lys-63-specific deubiquitinase BRCC36. (260 aa)
	LOC106532647	Protein FAM188B2 isoform X1. (441 aa)
	otud7b	OTU domain-containing protein 7B isoform X1. (923 aa)
	usp24	Ubiquitin carboxyl-terminal hydrolase 24 isoform X1; Belongs to the peptidase C19 family. (2595 aa)
	LOC106533142	Ubiquitin carboxyl-terminal hydrolase 11-like; Belongs to the peptidase C19 family. (1005 aa)
	usp14	Ubiquitin carboxyl-terminal hydrolase. (491 aa)
	LOC106533197	Sentrin-specific protease 2-like. (559 aa)
	usp42	Ubiquitin carboxyl-terminal hydrolase 42; Belongs to the peptidase C19 family. (1170 aa)
	LOC106533691	Ubiquitin carboxyl-terminal hydrolase 46; Belongs to the peptidase C19 family. (369 aa)
	otud5	OTU domain-containing protein 5. (555 aa)
	usp48	Ubiquitin carboxyl-terminal hydrolase 48 isoform X1; Belongs to the peptidase C19 family. (1038 aa)
	desi1	Desumoylating isopeptidase 1. (168 aa)
	bap1	Ubiquitin carboxyl-terminal hydrolase. (737 aa)
	LOC106534026	Ubiquitin carboxyl-terminal hydrolase. (598 aa)
	usp7	Ubiquitin carboxyl-terminal hydrolase 7 isoform X1; Belongs to the peptidase C19 family. (1103 aa)
	usp25	Ubiquitin carboxyl-terminal hydrolase 25; Belongs to the peptidase C19 family. (1079 aa)
	LOC106534595	Ataxin-7-like protein 2. (765 aa)
	usp44	Ubiquitin carboxyl-terminal hydrolase. (749 aa)
	LOC106534680	Desumoylating isopeptidase 1-like. (163 aa)
	LOC106535136	Ubiquitin carboxyl-terminal hydrolase 40-like. (906 aa)
	tnfaip3	Tumor necrosis factor alpha-induced protein 3. (815 aa)
	LOC106535137	Sentrin-specific protease 6-like. (550 aa)
	LOC106535310	Ubiquitin carboxyl-terminal hydrolase. (953 aa)
	LOC106535594	Ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1; Belongs to the peptidase C19 family. (764 aa)
	sgf29	SAGA-associated factor 29 homolog. (290 aa)
	cops2	COP9 signalosome complex subunit 2. (443 aa)
	LOC106536002	Ribonuclease ZC3H12A-like. (422 aa)
	LOC106536093	Ubiquitin carboxyl-terminal hydrolase 43-like; Belongs to the peptidase C19 family. (1216 aa)
	usp32	Ubiquitin carboxyl-terminal hydrolase 32; Belongs to the peptidase C19 family. (1492 aa)
	LOC106536595	Ubiquitin carboxyl-terminal hydrolase 32-like. (184 aa)
	LOC106536854	LOW QUALITY PROTEIN: probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1; Belongs to the peptidase C19 family. (2613 aa)
	LOC106536989	Inactive ubiquitin carboxyl-terminal hydrolase 54-like. (1009 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106511090	LOC106518679	A0A2I4AII5	A0A2I4BCN6	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Ubiquitin carboxyl-terminal hydrolase.	0.720
LOC106511090	LOC106521409	A0A2I4AII5	A0A2I4BNU5	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.	0.820
LOC106511090	LOC106521754	A0A2I4AII5	A0A2I4BQ87	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Ataxin-7-like protein 1.	0.741
LOC106511090	LOC106525206	A0A2I4AII5	A0A2I4C4B1	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Ataxin-7-like protein 2.	0.741
LOC106511090	LOC106527117	A0A2I4AII5	A0A2I4CBH5	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Ubiquitin carboxyl-terminal hydrolase.	0.720
LOC106511090	LOC106531363	A0A2I4AII5	A0A2I4CRQ6	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	0.900
LOC106511090	LOC106534595	A0A2I4AII5	A0A2I4D3C0	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Ataxin-7-like protein 2.	0.741
LOC106511090	atxn7	A0A2I4AII5	A0A2I4BC78	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Ataxin-7 isoform X1.	0.741
LOC106511090	atxn7l3	A0A2I4AII5	A0A2I4CCK4	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.	0.820
LOC106511090	eny2	A0A2I4AII5	A0A2I4CJU2	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...]	0.909
LOC106511090	sf3b5	A0A2I4AII5	A0A2I4DC45	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Splicing factor 3B subunit 5; Belongs to the SF3B5 family.	0.751
LOC106511090	sgf29	A0A2I4AII5	A0A2I4D7C9	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	SAGA-associated factor 29 homolog.	0.926
LOC106511090	supt3h	A0A2I4AII5	A0A2I4CJ83	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Transcription initiation protein SPT3 homolog.	0.936
LOC106511090	supt7l	A0A2I4AII5	A0A2I4BCI1	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	STAGA complex 65 subunit gamma.	0.953
LOC106511090	tada1	A0A2I4AII5	A0A2I4BNH0	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Transcriptional adapter 1.	0.813
LOC106511090	taf10	A0A2I4AII5	A0A2I4DD63	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Transcription initiation factor TFIID subunit 10.	0.957
LOC106511090	taf12	A0A2I4AII5	A0A2I4BYD8	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Transcription initiation factor TFIID subunit 12.	0.967
LOC106511090	taf5	A0A2I4AII5	A0A2I4BD42	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Transcription initiation factor TFIID subunit 5.	0.864
LOC106511090	taf5l	A0A2I4AII5	A0A2I4CRM3	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L.	0.916
LOC106511090	taf6	A0A2I4AII5	A0A2I4B323	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L.	Transcription initiation factor TFIID subunit 6.	0.906