STRINGSTRING
LOC106529655 LOC106529655 LOC106530103 LOC106530103 LOC106530509 LOC106530509 atxn1l atxn1l LOC106532229 LOC106532229 LOC106532230 LOC106532230 LOC106533898 LOC106533898 LOC106534096 LOC106534096 LOC106534548 LOC106534548 LOC106534650 LOC106534650 kdf1 kdf1 fermt1 fermt1 LOC106519273 LOC106519273 nf2 nf2 LOC106520852 LOC106520852 dgcr8 dgcr8 LOC106525496 LOC106525496 sirt6 sirt6 fgf4 fgf4 nf1 nf1 sox17 sox17 ptprc ptprc hmga2 hmga2 LOC106515883 LOC106515883 eif2ak2 eif2ak2 pdcd2 pdcd2 LOC106512371 LOC106512371 LOC106510986 LOC106510986 LOC106511033 LOC106511033 LOC106510838 LOC106510838
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC106529655Transforming growth factor beta-1-like. (474 aa)
LOC106530103Protein argonaute-3-like; Belongs to the argonaute family. (861 aa)
LOC106530509Cyclin-dependent kinase 4 inhibitor C-like. (169 aa)
atxn1lAtaxin-1-like. (811 aa)
LOC106532229Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (867 aa)
LOC106532230Protein argonaute-1. (585 aa)
LOC106533898Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (857 aa)
LOC106534096Transcription factor SOX-17-like. (431 aa)
LOC106534548Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
LOC106534650Neurofibromin. (2131 aa)
kdf1Keratinocyte differentiation factor 1. (388 aa)
fermt1Fermitin family homolog 1. (231 aa)
LOC106519273TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
nf2Merlin isoform X1. (591 aa)
LOC106520852TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (557 aa)
dgcr8Microprocessor complex subunit DGCR8. (784 aa)
LOC106525496TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
sirt6NAD-dependent protein deacetylase sirtuin-6. (349 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (227 aa)
nf1Neurofibromin isoform X1. (2016 aa)
sox17Transcription factor SOX-17. (395 aa)
ptprcReceptor-type tyrosine-protein phosphatase C. (863 aa)
hmga2High mobility group protein HMGI-C. (115 aa)
LOC106515883Interferon-induced, double-stranded RNA-activated protein kinase-like. (689 aa)
eif2ak2Interferon-induced, double-stranded RNA-activated protein kinase isoform X1. (685 aa)
pdcd2Programmed cell death protein 2 isoform X1. (358 aa)
LOC106512371Protein argonaute-3-like. (384 aa)
LOC106510986Fermitin family homolog 1-like. (666 aa)
LOC106511033Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
LOC106510838Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (868 aa)
Your Current Organism:
Austrofundulus limnaeus
NCBI taxonomy Id: 52670
Other names: A. limnaeus
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