(50 nodes) Extrinsic apoptotic signaling pathway network (Austrofundulus limnaeus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106519557	Glycogen synthase kinase-3 beta-like; Belongs to the protein kinase superfamily. (438 aa)
	daxx	Death domain-associated protein 6. (746 aa)
	siva1	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (168 aa)
	casp2	Caspase-2 isoform X1; Belongs to the peptidase C14A family. (491 aa)
	ddx47	Probable ATP-dependent RNA helicase DDX47; Belongs to the DEAD box helicase family. (488 aa)
	parp2	Poly [ADP-ribose] polymerase. (648 aa)
	dedd2	DNA-binding death effector domain-containing protein 2. (377 aa)
	pidd1	P53-induced death domain-containing protein 1. (1000 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (576 aa)
	LOC106522938	Tumor necrosis factor ligand superfamily member 12-like; Belongs to the tumor necrosis factor family. (238 aa)
	rnf41	E3 ubiquitin-protein ligase NRDP1. (317 aa)
	LOC106524069	Induced myeloid leukemia cell differentiation protein Mcl-1-like. (267 aa)
	bad	Bcl2-associated agonist of cell death. (165 aa)
	LOC106525615	BAG family molecular chaperone regulator 3-like. (487 aa)
	LOC106526561	FAS-associated death domain protein-like. (196 aa)
	nf1	Neurofibromin isoform X1. (2016 aa)
	LOC106526563	Apoptosis regulator BAX-like isoform X1. (203 aa)
	casp8ap2	CASP8-associated protein 2. (1772 aa)
	LOC106528358	Apoptosis regulator BAX-like. (192 aa)
	LOC106529655	Transforming growth factor beta-1-like. (474 aa)
	g0s2	G0/G1 switch protein 2. (120 aa)
	gsk3b	Glycogen synthase kinase-3 beta. (138 aa)
	LOC106531394	Bcl-2-like protein 1. (218 aa)
	tradd	Tumor necrosis factor receptor type 1-associated DEATH domain protein. (292 aa)
	bok	Bcl-2-related ovarian killer protein. (211 aa)
	bcl2l1	Bcl-2-like protein 1. (226 aa)
	LOC106532331	Glycogen synthase kinase-3 alpha-like; Belongs to the protein kinase superfamily. (440 aa)
	rb1cc1	RB1-inducible coiled-coil protein 1. (1618 aa)
	LOC106534591	Bcl-2-related ovarian killer protein-like isoform X1. (229 aa)
	LOC106534650	Neurofibromin. (2131 aa)
	LOC106534700	G0/G1 switch protein 2-like. (112 aa)
	itprip	Inositol 1,4,5-trisphosphate receptor-interacting protein. (543 aa)
	LOC106535067	Tumor necrosis factor receptor superfamily member 6-like. (316 aa)
	LOC106535279	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (421 aa)
	LOC106537247	Tumor necrosis factor receptor superfamily member 10B-like isoform X1. (408 aa)
	LOC106535953	Tumor necrosis factor ligand superfamily member 12-like; Belongs to the tumor necrosis factor family. (113 aa)
	LOC106511172	Glycogen synthase kinase-3 beta-like. (128 aa)
	LOC106512210	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (188 aa)
	LOC106512618	Caspase-8-like; Belongs to the peptidase C14A family. (294 aa)
	LOC106512902	Caspase-8-like; Belongs to the peptidase C14A family. (531 aa)
	LOC106513113	Tumor necrosis factor receptor superfamily member 10B-like. (449 aa)
	LOC106513844	Tumor necrosis factor receptor superfamily member 5-like. (452 aa)
	LOC106514773	Sortilin. (820 aa)
	bcl2l11	Bcl-2-like protein 11. (235 aa)
	LOC106515824	Transforming growth factor beta; Belongs to the TGF-beta family. (421 aa)
	skil	Ski-like protein. (757 aa)
	kiaa0141	Death ligand signal enhancer. (508 aa)
	LOC106517939	Caspase-8-like; Belongs to the peptidase C14A family. (467 aa)
	LOC106518755	Inositol 1,4,5-trisphosphate receptor-interacting protein-like. (582 aa)
	LOC106518981	LOW QUALITY PROTEIN: anti-apoptotic protein NR13-like. (192 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106512210	LOC106512618	A0A2I4ALF1	A0A2I4AMB2	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Caspase-8-like; Belongs to the peptidase C14A family.	0.823
LOC106512210	LOC106512902	A0A2I4ALF1	A0A2I4AN31	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Caspase-8-like; Belongs to the peptidase C14A family.	0.868
LOC106512210	LOC106513113	A0A2I4ALF1	A0A2I4AP25	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 10B-like.	0.857
LOC106512210	LOC106513844	A0A2I4ALF1	A0A2I4AS38	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 5-like.	0.407
LOC106512210	LOC106517939	A0A2I4ALF1	A0A2I4B9N4	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Caspase-8-like; Belongs to the peptidase C14A family.	0.890
LOC106512210	LOC106526561	A0A2I4ALF1	A0A2I4C9H4	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	FAS-associated death domain protein-like.	0.938
LOC106512210	LOC106529655	A0A2I4ALF1	A0A2I4CKS2	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Transforming growth factor beta-1-like.	0.413
LOC106512210	LOC106535067	A0A2I4ALF1	A0A2I4D578	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 6-like.	0.997
LOC106512210	LOC106537247	A0A2I4ALF1	A0A2I4DCY5	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 10B-like isoform X1.	0.635
LOC106512210	bcl2l11	A0A2I4ALF1	A0A2I4AYQ4	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Bcl-2-like protein 11.	0.575
LOC106512210	casp2	A0A2I4ALF1	A0A2I4BJY7	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Caspase-2 isoform X1; Belongs to the peptidase C14A family.	0.566
LOC106512210	daxx	A0A2I4ALF1	A0A2I4BG79	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Death domain-associated protein 6.	0.466
LOC106512210	tradd	A0A2I4ALF1	A0A2I4CTR9	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor type 1-associated DEATH domain protein.	0.821
LOC106512618	LOC106512210	A0A2I4AMB2	A0A2I4ALF1	Caspase-8-like; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	0.823
LOC106512618	LOC106512902	A0A2I4AMB2	A0A2I4AN31	Caspase-8-like; Belongs to the peptidase C14A family.	Caspase-8-like; Belongs to the peptidase C14A family.	0.900
LOC106512618	LOC106513113	A0A2I4AMB2	A0A2I4AP25	Caspase-8-like; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 10B-like.	0.814
LOC106512618	LOC106517939	A0A2I4AMB2	A0A2I4B9N4	Caspase-8-like; Belongs to the peptidase C14A family.	Caspase-8-like; Belongs to the peptidase C14A family.	0.905
LOC106512618	LOC106524069	A0A2I4AMB2	A0A2I4BZJ0	Caspase-8-like; Belongs to the peptidase C14A family.	Induced myeloid leukemia cell differentiation protein Mcl-1-like.	0.437
LOC106512618	LOC106526561	A0A2I4AMB2	A0A2I4C9H4	Caspase-8-like; Belongs to the peptidase C14A family.	FAS-associated death domain protein-like.	0.992
LOC106512618	LOC106528358	A0A2I4AMB2	A0A2I4CG32	Caspase-8-like; Belongs to the peptidase C14A family.	Apoptosis regulator BAX-like.	0.422