(20 nodes) Extrinsic apoptotic signaling pathway in absence of ligand network (Austrofundulus limnaeus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	LOC106518981	LOW QUALITY PROTEIN: anti-apoptotic protein NR13-like. (192 aa)
	LOC106511172	Glycogen synthase kinase-3 beta-like. (128 aa)
	bcl2l11	Bcl-2-like protein 11. (235 aa)
	LOC106519557	Glycogen synthase kinase-3 beta-like; Belongs to the protein kinase superfamily. (438 aa)
	casp2	Caspase-2 isoform X1; Belongs to the peptidase C14A family. (491 aa)
	LOC106524069	Induced myeloid leukemia cell differentiation protein Mcl-1-like. (267 aa)
	bad	Bcl2-associated agonist of cell death. (165 aa)
	LOC106525615	BAG family molecular chaperone regulator 3-like. (487 aa)
	LOC106526561	FAS-associated death domain protein-like. (196 aa)
	nf1	Neurofibromin isoform X1. (2016 aa)
	LOC106526563	Apoptosis regulator BAX-like isoform X1. (203 aa)
	LOC106528358	Apoptosis regulator BAX-like. (192 aa)
	gsk3b	Glycogen synthase kinase-3 beta. (138 aa)
	LOC106531394	Bcl-2-like protein 1. (218 aa)
	bok	Bcl-2-related ovarian killer protein. (211 aa)
	bcl2l1	Bcl-2-like protein 1. (226 aa)
	LOC106532331	Glycogen synthase kinase-3 alpha-like; Belongs to the protein kinase superfamily. (440 aa)
	LOC106534591	Bcl-2-related ovarian killer protein-like isoform X1. (229 aa)
	LOC106534650	Neurofibromin. (2131 aa)
	LOC106535279	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (421 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106518981	LOC106524069	A0A2I4BDS0	A0A2I4BZJ0	LOW QUALITY PROTEIN: anti-apoptotic protein NR13-like.	Induced myeloid leukemia cell differentiation protein Mcl-1-like.	0.450
LOC106518981	LOC106526563	A0A2I4BDS0	A0A2I4C9J6	LOW QUALITY PROTEIN: anti-apoptotic protein NR13-like.	Apoptosis regulator BAX-like isoform X1.	0.439
LOC106518981	LOC106531394	A0A2I4BDS0	A0A2I4CRT7	LOW QUALITY PROTEIN: anti-apoptotic protein NR13-like.	Bcl-2-like protein 1.	0.438
LOC106518981	bad	A0A2I4BDS0	A0A2I4C3A9	LOW QUALITY PROTEIN: anti-apoptotic protein NR13-like.	Bcl2-associated agonist of cell death.	0.884
LOC106518981	bcl2l1	A0A2I4BDS0	A0A2I4CUJ7	LOW QUALITY PROTEIN: anti-apoptotic protein NR13-like.	Bcl-2-like protein 1.	0.438
LOC106518981	bcl2l11	A0A2I4BDS0	A0A2I4AYQ4	LOW QUALITY PROTEIN: anti-apoptotic protein NR13-like.	Bcl-2-like protein 11.	0.947
LOC106518981	bok	A0A2I4BDS0	A0A2I4CU02	LOW QUALITY PROTEIN: anti-apoptotic protein NR13-like.	Bcl-2-related ovarian killer protein.	0.406
LOC106524069	LOC106518981	A0A2I4BZJ0	A0A2I4BDS0	Induced myeloid leukemia cell differentiation protein Mcl-1-like.	LOW QUALITY PROTEIN: anti-apoptotic protein NR13-like.	0.450
LOC106524069	LOC106526563	A0A2I4BZJ0	A0A2I4C9J6	Induced myeloid leukemia cell differentiation protein Mcl-1-like.	Apoptosis regulator BAX-like isoform X1.	0.938
LOC106524069	LOC106531394	A0A2I4BZJ0	A0A2I4CRT7	Induced myeloid leukemia cell differentiation protein Mcl-1-like.	Bcl-2-like protein 1.	0.446
LOC106524069	LOC106534591	A0A2I4BZJ0	A0A2I4D3D4	Induced myeloid leukemia cell differentiation protein Mcl-1-like.	Bcl-2-related ovarian killer protein-like isoform X1.	0.497
LOC106524069	bad	A0A2I4BZJ0	A0A2I4C3A9	Induced myeloid leukemia cell differentiation protein Mcl-1-like.	Bcl2-associated agonist of cell death.	0.781
LOC106524069	bcl2l1	A0A2I4BZJ0	A0A2I4CUJ7	Induced myeloid leukemia cell differentiation protein Mcl-1-like.	Bcl-2-like protein 1.	0.446
LOC106524069	bcl2l11	A0A2I4BZJ0	A0A2I4AYQ4	Induced myeloid leukemia cell differentiation protein Mcl-1-like.	Bcl-2-like protein 11.	0.999
LOC106524069	bok	A0A2I4BZJ0	A0A2I4CU02	Induced myeloid leukemia cell differentiation protein Mcl-1-like.	Bcl-2-related ovarian killer protein.	0.646
LOC106524069	casp2	A0A2I4BZJ0	A0A2I4BJY7	Induced myeloid leukemia cell differentiation protein Mcl-1-like.	Caspase-2 isoform X1; Belongs to the peptidase C14A family.	0.442
LOC106526561	LOC106531394	A0A2I4C9H4	A0A2I4CRT7	FAS-associated death domain protein-like.	Bcl-2-like protein 1.	0.411
LOC106526561	bcl2l1	A0A2I4C9H4	A0A2I4CUJ7	FAS-associated death domain protein-like.	Bcl-2-like protein 1.	0.411
LOC106526561	casp2	A0A2I4C9H4	A0A2I4BJY7	FAS-associated death domain protein-like.	Caspase-2 isoform X1; Belongs to the peptidase C14A family.	0.589
LOC106526563	LOC106518981	A0A2I4C9J6	A0A2I4BDS0	Apoptosis regulator BAX-like isoform X1.	LOW QUALITY PROTEIN: anti-apoptotic protein NR13-like.	0.439