(5 nodes) Ubiquitin-activating enzyme E1, Cys active site network (Austrofundulus limnaeus)

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Your Input:
	uba3	NEDD8-activating enzyme E1 catalytic subunit isoform X1. (446 aa)
	LOC106534960	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1013 aa)
	uba1	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1056 aa)
	uba2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (641 aa)
	LOC106519301	NEDD8-activating enzyme E1 catalytic subunit. (460 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106519301	LOC106534960	A0A2I4BF36	A0A2I4D4R7	NEDD8-activating enzyme E1 catalytic subunit.	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.668
LOC106519301	uba1	A0A2I4BF36	A0A2I4BZJ5	NEDD8-activating enzyme E1 catalytic subunit.	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.668
LOC106519301	uba3	A0A2I4BF36	A0A2I4BC28	NEDD8-activating enzyme E1 catalytic subunit.	NEDD8-activating enzyme E1 catalytic subunit isoform X1.	0.900
LOC106534960	LOC106519301	A0A2I4D4R7	A0A2I4BF36	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	NEDD8-activating enzyme E1 catalytic subunit.	0.668
LOC106534960	uba1	A0A2I4D4R7	A0A2I4BZJ5	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.902
LOC106534960	uba2	A0A2I4D4R7	A0A2I4BIX3	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.413
LOC106534960	uba3	A0A2I4D4R7	A0A2I4BC28	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	NEDD8-activating enzyme E1 catalytic subunit isoform X1.	0.668
uba1	LOC106519301	A0A2I4BZJ5	A0A2I4BF36	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	NEDD8-activating enzyme E1 catalytic subunit.	0.668
uba1	LOC106534960	A0A2I4BZJ5	A0A2I4D4R7	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.902
uba1	uba2	A0A2I4BZJ5	A0A2I4BIX3	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.413
uba1	uba3	A0A2I4BZJ5	A0A2I4BC28	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	NEDD8-activating enzyme E1 catalytic subunit isoform X1.	0.668
uba2	LOC106534960	A0A2I4BIX3	A0A2I4D4R7	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.413
uba2	uba1	A0A2I4BIX3	A0A2I4BZJ5	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.413
uba3	LOC106519301	A0A2I4BC28	A0A2I4BF36	NEDD8-activating enzyme E1 catalytic subunit isoform X1.	NEDD8-activating enzyme E1 catalytic subunit.	0.900
uba3	LOC106534960	A0A2I4BC28	A0A2I4D4R7	NEDD8-activating enzyme E1 catalytic subunit isoform X1.	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.668
uba3	uba1	A0A2I4BC28	A0A2I4BZJ5	NEDD8-activating enzyme E1 catalytic subunit isoform X1.	Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.668