(23 nodes) Histidine kinase/HSP90-like ATPase superfamily network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106516151	MORC family CW-type zinc finger protein 3-like isoform X1. (907 aa)
	LOC106536555	PMS1 protein homolog 1-like. (841 aa)
	pdk1	Protein-serine/threonine kinase. (407 aa)
	mlh1	DNA mismatch repair protein Mlh1 isoform X1. (743 aa)
	hsp90b1	Endoplasmin. (798 aa)
	LOC106534797	Protein-serine/threonine kinase. (410 aa)
	LOC106533044	Heat shock protein HSP 90-alpha 1. (724 aa)
	LOC106533043	LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like. (733 aa)
	LOC106532548	Uncharacterized protein LOC106532548. (2948 aa)
	pms2	Mismatch repair endonuclease PMS2. (845 aa)
	top2b	DNA topoisomerase 2-beta. (2140 aa)
	morc3	MORC family CW-type zinc finger protein 3 isoform X1. (1018 aa)
	LOC106526454	Sacsin-like. (4271 aa)
	bckdk	Protein-serine/threonine kinase. (428 aa)
	pdk3	Protein-serine/threonine kinase. (403 aa)
	hsp90ab1	Heat shock protein HSP 90-beta. (724 aa)
	sacs	Sacsin isoform X1. (4588 aa)
	LOC106521954	Protein-serine/threonine kinase. (408 aa)
	morc2	MORC family CW-type zinc finger protein 2. (1054 aa)
	smchd1	Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (1947 aa)
	mlh3	DNA mismatch repair protein Mlh3 isoform X1. (1163 aa)
	trap1	Heat shock protein 75 kDa, mitochondrial. (723 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1571 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106533043	LOC106533044	A0A2I4CXH8	A0A2I4CXJ1	LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like.	Heat shock protein HSP 90-alpha 1.	0.900
LOC106533043	hsp90ab1	A0A2I4CXH8	A0A2I4BT45	LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like.	Heat shock protein HSP 90-beta.	0.937
LOC106533044	LOC106533043	A0A2I4CXJ1	A0A2I4CXH8	Heat shock protein HSP 90-alpha 1.	LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like.	0.900
LOC106533044	hsp90ab1	A0A2I4CXJ1	A0A2I4BT45	Heat shock protein HSP 90-alpha 1.	Heat shock protein HSP 90-beta.	0.937
LOC106536555	mlh1	A0A2I4DAP6	A0A2I4AZK9	PMS1 protein homolog 1-like.	DNA mismatch repair protein Mlh1 isoform X1.	0.946
LOC106536555	mlh3	A0A2I4DAP6	A0A2I4BKA5	PMS1 protein homolog 1-like.	DNA mismatch repair protein Mlh3 isoform X1.	0.769
LOC106536555	pms2	A0A2I4DAP6	A0A2I4CT89	PMS1 protein homolog 1-like.	Mismatch repair endonuclease PMS2.	0.809
hsp90ab1	LOC106533043	A0A2I4BT45	A0A2I4CXH8	Heat shock protein HSP 90-beta.	LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like.	0.937
hsp90ab1	LOC106533044	A0A2I4BT45	A0A2I4CXJ1	Heat shock protein HSP 90-beta.	Heat shock protein HSP 90-alpha 1.	0.937
mlh1	LOC106536555	A0A2I4AZK9	A0A2I4DAP6	DNA mismatch repair protein Mlh1 isoform X1.	PMS1 protein homolog 1-like.	0.946
mlh1	mlh3	A0A2I4AZK9	A0A2I4BKA5	DNA mismatch repair protein Mlh1 isoform X1.	DNA mismatch repair protein Mlh3 isoform X1.	0.980
mlh1	pms2	A0A2I4AZK9	A0A2I4CT89	DNA mismatch repair protein Mlh1 isoform X1.	Mismatch repair endonuclease PMS2.	0.995
mlh3	LOC106536555	A0A2I4BKA5	A0A2I4DAP6	DNA mismatch repair protein Mlh3 isoform X1.	PMS1 protein homolog 1-like.	0.769
mlh3	mlh1	A0A2I4BKA5	A0A2I4AZK9	DNA mismatch repair protein Mlh3 isoform X1.	DNA mismatch repair protein Mlh1 isoform X1.	0.980
mlh3	pms2	A0A2I4BKA5	A0A2I4CT89	DNA mismatch repair protein Mlh3 isoform X1.	Mismatch repair endonuclease PMS2.	0.788
pms2	LOC106536555	A0A2I4CT89	A0A2I4DAP6	Mismatch repair endonuclease PMS2.	PMS1 protein homolog 1-like.	0.809
pms2	mlh1	A0A2I4CT89	A0A2I4AZK9	Mismatch repair endonuclease PMS2.	DNA mismatch repair protein Mlh1 isoform X1.	0.995
pms2	mlh3	A0A2I4CT89	A0A2I4BKA5	Mismatch repair endonuclease PMS2.	DNA mismatch repair protein Mlh3 isoform X1.	0.788