Your Input: | |
| | nhej1 | Non-homologous end-joining factor 1. (312 aa) |
| | xrcc3 | DNA repair protein XRCC3. (344 aa) |
| | LOC106527735 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC106527833 | Histone H2A; Belongs to the histone H2A family. (146 aa) |
| | LOC106527857 | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (499 aa) |
| | pold1 | DNA polymerase. (1105 aa) |
| | LOC106528345 | Importin subunit alpha; Belongs to the importin alpha family. (492 aa) |
| | kpna2 | Importin subunit alpha; Belongs to the importin alpha family. (512 aa) |
| | rmi2 | recQ-mediated genome instability protein 2. (147 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (311 aa) |
| | LOC106529278 | RCC1 and BTB domain-containing protein 1-like isoform X1. (615 aa) |
| | LOC106529398 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (641 aa) |
| | LOC106529676 | Uncharacterized protein LOC106529676. (373 aa) |
| | ppp5c | Serine/threonine-protein phosphatase. (495 aa) |
| | apbb1 | Amyloid beta A4 precursor protein-binding family B member 1 isoform X1. (687 aa) |
| | xrcc1 | DNA repair protein XRCC1. (624 aa) |
| | cdca7l | Cell division cycle-associated 7-like protein. (386 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa) |
| | LOC106531057 | DNA repair-scaffolding protein-like. (919 aa) |
| | sumo1 | Small ubiquitin-related modifier. (101 aa) |
| | LOC106532041 | Structure-specific endonuclease subunit SLX4-like. (234 aa) |
| | tdp1 | tyrosyl-DNA phosphodiesterase 1. (607 aa) |
| | brcc3 | Lys-63-specific deubiquitinase BRCC36. (260 aa) |
| | LOC106532534 | Structure-specific endonuclease subunit SLX4-like. (1650 aa) |
| | abl1 | Tyrosine-protein kinase. (1115 aa) |
| | LOC106532596 | X-ray repair cross-complementing protein 5-like. (411 aa) |
| | LOC106536681 | Ubiquitin-conjugating enzyme E2 variant 1-like. (170 aa) |
| | LOC106536586 | Probable flap endonuclease 1 homolog. (346 aa) |
| | LOC106536580 | RCC1 and BTB domain-containing protein 1-like. (531 aa) |
| | baz1b | Tyrosine-protein kinase BAZ1B isoform X1. (1586 aa) |
| | recql4 | ATP-dependent DNA helicase Q4. (1480 aa) |
| | chek2 | Serine/threonine-protein kinase Chk2. (537 aa) |
| | LOC106535981 | Cell cycle checkpoint control protein RAD9B-like. (395 aa) |
| | exd2 | Exonuclease 3'-5' domain-containing protein 2. (669 aa) |
| | dclre1c | Protein artemis. (615 aa) |
| | LOC106535502 | DNA-dependent protein kinase catalytic subunit-like; Belongs to the PI3/PI4-kinase family. (4105 aa) |
| | rfc1 | Replication factor C subunit 1. (1170 aa) |
| | LOC106535400 | DNA repair protein XRCC2-like. (288 aa) |
| | tmem182 | Transmembrane protein 182. (235 aa) |
| | LOC106535129 | E3 ubiquitin-protein ligase RNF168-like. (194 aa) |
| | LOC106534679 | X-ray repair cross-complementing protein 6-like. (138 aa) |
| | LOC106534592 | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (808 aa) |
| | eme1 | Crossover junction endonuclease EME1 isoform X1. (509 aa) |
| | LOC106534377 | LOW QUALITY PROTEIN: histone H2B.3-like; Belongs to the histone H2B family. (66 aa) |
| | atr | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2609 aa) |
| | pole3 | DNA polymerase epsilon subunit 3. (150 aa) |
| | rad17 | Cell cycle checkpoint protein RAD17. (632 aa) |
| | spidr | DNA repair-scaffolding protein. (610 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | LOC106533547 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | LOC106533484 | Serine/threonine-protein phosphatase 4 regulatory subunit 2-B-like. (91 aa) |
| | LOC106533213 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa) |
| | rfc2 | Replication factor C subunit 2. (346 aa) |
| | pold4 | DNA polymerase delta subunit 4. (112 aa) |
| | polk | DNA polymerase kappa. (877 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | LOC106510828 | Bromodomain adjacent to zinc finger domain protein 1A-like. (738 aa) |
| | LOC106510870 | E3 ubiquitin-protein ligase RNF168-like. (421 aa) |
| | rps27a | ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | rad51c | DNA repair protein RAD51 homolog 3. (348 aa) |
| | LOC106511277 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (270 aa) |
| | LOC106511409 | Poly [ADP-ribose] polymerase. (395 aa) |
| | LOC106511709 | DNA repair protein XRCC2-like. (166 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (316 aa) |
| | LOC106511871 | Structure-specific endonuclease subunit SLX4-like. (119 aa) |
| | LOC106512025 | Checkpoint protein HUS1-like. (349 aa) |
| | LOC106512407 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | LOC106512639 | Cell cycle checkpoint protein RAD17-like. (193 aa) |
| | cdca7 | Cell division cycle-associated protein 7 isoform X1. (402 aa) |
| | rbbp8 | DNA endonuclease RBBP8. (632 aa) |
| | LOC106513019 | Histone H2B 1/2-like; Belongs to the histone H2B family. (111 aa) |
| | dna2 | DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1376 aa) |
| | LOC106513356 | Ubiquitin-like. (85 aa) |
| | eya1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (614 aa) |
| | polh | DNA polymerase eta. (737 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | fam175a | BRCA1-A complex subunit Abraxas. (354 aa) |
| | tdrd3 | Tudor domain-containing protein 3. (787 aa) |
| | chek1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (455 aa) |
| | ccna1 | cyclin-A1; Belongs to the cyclin family. (406 aa) |
| | rfc3 | Replication factor C subunit 3. (356 aa) |
| | blm | Bloom syndrome protein isoform X1. (1417 aa) |
| | lig3 | DNA ligase. (1012 aa) |
| | rad51d | DNA repair protein RAD51 homolog 4 isoform X1. (333 aa) |
| | uimc1 | BRCA1-A complex subunit RAP80 isoform X1. (946 aa) |
| | rad51ap1 | RAD51-associated protein 1 isoform X1. (306 aa) |
| | pias4 | E3 SUMO-protein ligase PIAS4. (508 aa) |
| | LOC106515271 | Small ubiquitin-related modifier. (96 aa) |
| | mre11a | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (694 aa) |
| | LOC106515610 | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | tdp2 | tyrosyl-DNA phosphodiesterase 2 isoform X1. (360 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (574 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (383 aa) |
| | pold2 | DNA polymerase delta subunit 2. (471 aa) |
| | babam1 | BRISC and BRCA1-A complex member 1 isoform X1. (429 aa) |
| | brca1 | Breast cancer type 1 susceptibility protein. (1346 aa) |
| | smarca5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (1037 aa) |
| | LOC106517127 | DNA-dependent protein kinase catalytic subunit-like; Belongs to the PI3/PI4-kinase family. (4105 aa) |
| | rfc4 | Replication factor C subunit 4. (356 aa) |
| | LOC106517370 | SUMO-conjugating enzyme UBC9-B; Belongs to the ubiquitin-conjugating enzyme family. (138 aa) |
| | eme2 | Probable crossover junction endonuclease EME2 isoform X1. (434 aa) |
| | topbp1 | DNA topoisomerase 2-binding protein 1. (1505 aa) |
| | xrcc4 | DNA repair protein XRCC4. (293 aa) |
| | LOC106517645 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (476 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (583 aa) |
| | timeless | Protein timeless homolog. (1252 aa) |
| | rad1 | Cell cycle checkpoint protein RAD1. (280 aa) |
| | LOC106518264 | Serine/threonine-protein phosphatase 4 regulatory subunit 2-B-like. (422 aa) |
| | LOC106518458 | Small ubiquitin-related modifier. (94 aa) |
| | gen1 | Flap endonuclease GEN homolog 1. (818 aa) |
| | bre | BRCA1-A complex subunit BRE. (386 aa) |
| | poll | DNA polymerase lambda; Belongs to the DNA polymerase type-X family. (568 aa) |
| | LOC106518873 | Ubiquitin-like. (76 aa) |
| | lig4 | DNA ligase. (909 aa) |
| | LOC106519213 | Lysine-specific demethylase 4B-like. (1292 aa) |
| | uba52 | ubiquitin-60S ribosomal protein L40. (128 aa) |
| | LOC106519292 | Serine/threonine-protein phosphatase 4 regulatory subunit 2-A-like. (414 aa) |
| | rfc5 | Replication factor C subunit 5. (335 aa) |
| | whsc1 | Histone-lysine N-methyltransferase NSD2. (1298 aa) |
| | kxd1 | kxDL motif-containing protein 1. (181 aa) |
| | rad52 | DNA repair protein RAD52 homolog isoform X2. (426 aa) |
| | slf1 | Ankyrin repeat domain-containing protein 32. (875 aa) |
| | rcbtb2 | RCC1 and BTB domain-containing protein 2. (527 aa) |
| | atm | Non-specific serine/threonine protein kinase. (3066 aa) |
| | ube2i | SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1014 aa) |
| | parp2 | Poly [ADP-ribose] polymerase. (648 aa) |
| | polq | DNA polymerase theta isoform X1. (2713 aa) |
| | mdc1 | Mediator of DNA damage checkpoint protein 1 isoform X1. (1884 aa) |
| | rhno1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (289 aa) |
| | paxip1 | PAX-interacting protein 1. (1049 aa) |
| | LOC106521431 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | sirt7 | NAD-dependent protein deacetylase sirtuin-7. (409 aa) |
| | brca2 | Breast cancer type 2 susceptibility protein. (3474 aa) |
| | pole4 | DNA polymerase epsilon subunit 4 isoform X1. (128 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2287 aa) |
| | LOC106521775 | Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | LOC106521853 | Putative ankyrin repeat domain-containing protein 31. (564 aa) |
| | sumo2 | Small ubiquitin-related modifier. (95 aa) |
| | LOC106522150 | Serine-protein kinase ATM-like; Belongs to the PI3/PI4-kinase family. (391 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (522 aa) |
| | palb2 | Partner and localizer of BRCA2. (1290 aa) |
| | atrip | LOW QUALITY PROTEIN: ATR-interacting protein. (782 aa) |
| | LOC106522875 | Transmembrane protein 182-like. (259 aa) |
| | pold3 | DNA polymerase delta subunit 3. (437 aa) |
| | xrcc5 | X-ray repair cross-complementing protein 5 isoform X1. (755 aa) |
| | LOC106523318 | Small ubiquitin-related modifier. (94 aa) |
| | LOC106523505 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa) |
| | LOC106523691 | X-ray repair cross-complementing protein 5-like. (610 aa) |
| | LOC106523874 | Importin subunit alpha; Belongs to the importin alpha family. (523 aa) |
| | cnppd1 | Protein CNPPD1. (432 aa) |
| | eya4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (650 aa) |
| | rad50 | DNA repair protein RAD50. (1312 aa) |
| | LOC106525098 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | rpa3 | Replication protein A 14 kDa subunit. (122 aa) |
| | meiob | Meiosis-specific with OB domain-containing protein. (463 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (355 aa) |
| | exo1 | Exonuclease 1. (825 aa) |
| | ankrd12 | Ankyrin repeat domain-containing protein 12 isoform X1. (1914 aa) |
| | ccna2 | cyclin-A2; Belongs to the cyclin family. (435 aa) |
| | LOC106526051 | DNA repair protein XRCC4-like isoform X1. (339 aa) |
| | rmi1 | recQ-mediated genome instability protein 1. (690 aa) |
| | rnf169 | E3 ubiquitin-protein ligase RNF169. (577 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa) |
| | polm | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (506 aa) |
| | sirt6 | NAD-dependent protein deacetylase sirtuin-6. (349 aa) |
| | rif1 | Telomere-associated protein RIF1 isoform X1. (2335 aa) |
| | mus81 | Crossover junction endonuclease MUS81 isoform X2. (596 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa) |
| | rpa2 | Replication protein A 32 kDa subunit. (272 aa) |
| | tp53bp1 | Tumor suppressor p53-binding protein 1. (1713 aa) |
| | LOC106527012 | tyrosyl-DNA phosphodiesterase 2-like. (298 aa) |
