STRINGSTRING
nhej1 nhej1 xrcc3 xrcc3 LOC106527735 LOC106527735 LOC106527833 LOC106527833 LOC106527857 LOC106527857 pold1 pold1 LOC106528345 LOC106528345 kpna2 kpna2 rmi2 rmi2 ppp4c ppp4c LOC106529278 LOC106529278 LOC106529398 LOC106529398 LOC106529676 LOC106529676 ppp5c ppp5c apbb1 apbb1 xrcc1 xrcc1 cdca7l cdca7l fen1 fen1 rad51 rad51 LOC106531057 LOC106531057 sumo1 sumo1 LOC106532041 LOC106532041 tdp1 tdp1 brcc3 brcc3 LOC106532534 LOC106532534 abl1 abl1 LOC106532596 LOC106532596 LOC106536681 LOC106536681 LOC106536586 LOC106536586 LOC106536580 LOC106536580 baz1b baz1b recql4 recql4 chek2 chek2 LOC106535981 LOC106535981 exd2 exd2 dclre1c dclre1c LOC106535502 LOC106535502 rfc1 rfc1 LOC106535400 LOC106535400 tmem182 tmem182 LOC106535129 LOC106535129 LOC106534679 LOC106534679 LOC106534592 LOC106534592 eme1 eme1 LOC106534377 LOC106534377 atr atr pole3 pole3 rad17 rad17 spidr spidr ube2v2 ube2v2 LOC106533547 LOC106533547 LOC106533484 LOC106533484 LOC106533213 LOC106533213 rfc2 rfc2 pold4 pold4 polk polk cdk2 cdk2 LOC106510828 LOC106510828 LOC106510870 LOC106510870 rps27a rps27a rad51c rad51c LOC106511277 LOC106511277 LOC106511409 LOC106511409 LOC106511709 LOC106511709 tipin tipin LOC106511871 LOC106511871 LOC106512025 LOC106512025 LOC106512407 LOC106512407 LOC106512639 LOC106512639 cdca7 cdca7 rbbp8 rbbp8 LOC106513019 LOC106513019 dna2 dna2 LOC106513356 LOC106513356 eya1 eya1 polh polh pcna pcna fam175a fam175a tdrd3 tdrd3 chek1 chek1 ccna1 ccna1 rfc3 rfc3 blm blm lig3 lig3 rad51d rad51d uimc1 uimc1 rad51ap1 rad51ap1 pias4 pias4 LOC106515271 LOC106515271 mre11a mre11a LOC106515610 LOC106515610 tdp2 tdp2 kat5 kat5 rad9a rad9a pold2 pold2 babam1 babam1 brca1 brca1 smarca5 smarca5 LOC106517127 LOC106517127 rfc4 rfc4 LOC106517370 LOC106517370 eme2 eme2 topbp1 topbp1 xrcc4 xrcc4 LOC106517645 LOC106517645 parp3 parp3 timeless timeless rad1 rad1 LOC106518264 LOC106518264 LOC106518458 LOC106518458 gen1 gen1 bre bre poll poll LOC106518873 LOC106518873 lig4 lig4 LOC106519213 LOC106519213 uba52 uba52 LOC106519292 LOC106519292 rfc5 rfc5 whsc1 whsc1 kxd1 kxd1 rad52 rad52 slf1 slf1 rcbtb2 rcbtb2 atm atm ube2i ube2i top3a top3a parp2 parp2 polq polq mdc1 mdc1 rhno1 rhno1 paxip1 paxip1 LOC106521431 LOC106521431 sirt7 sirt7 brca2 brca2 pole4 pole4 pole pole LOC106521775 LOC106521775 LOC106521853 LOC106521853 sumo2 sumo2 LOC106522150 LOC106522150 rnf8 rnf8 palb2 palb2 atrip atrip LOC106522875 LOC106522875 pold3 pold3 xrcc5 xrcc5 LOC106523318 LOC106523318 LOC106523505 LOC106523505 LOC106523691 LOC106523691 LOC106523874 LOC106523874 cnppd1 cnppd1 eya4 eya4 rad50 rad50 LOC106525098 LOC106525098 rpa3 rpa3 meiob meiob tp53 tp53 exo1 exo1 ankrd12 ankrd12 ccna2 ccna2 LOC106526051 LOC106526051 rmi1 rmi1 rnf169 rnf169 pole2 pole2 polm polm sirt6 sirt6 rif1 rif1 mus81 mus81 parp1 parp1 rpa2 rpa2 tp53bp1 tp53bp1 LOC106527012 LOC106527012
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nhej1Non-homologous end-joining factor 1. (312 aa)
xrcc3DNA repair protein XRCC3. (344 aa)
LOC106527735Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC106527833Histone H2A; Belongs to the histone H2A family. (146 aa)
LOC106527857DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (499 aa)
pold1DNA polymerase. (1105 aa)
LOC106528345Importin subunit alpha; Belongs to the importin alpha family. (492 aa)
kpna2Importin subunit alpha; Belongs to the importin alpha family. (512 aa)
rmi2recQ-mediated genome instability protein 2. (147 aa)
ppp4cSerine/threonine-protein phosphatase. (311 aa)
LOC106529278RCC1 and BTB domain-containing protein 1-like isoform X1. (615 aa)
LOC106529398Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (641 aa)
LOC106529676Uncharacterized protein LOC106529676. (373 aa)
ppp5cSerine/threonine-protein phosphatase. (495 aa)
apbb1Amyloid beta A4 precursor protein-binding family B member 1 isoform X1. (687 aa)
xrcc1DNA repair protein XRCC1. (624 aa)
cdca7lCell division cycle-associated 7-like protein. (386 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
LOC106531057DNA repair-scaffolding protein-like. (919 aa)
sumo1Small ubiquitin-related modifier. (101 aa)
LOC106532041Structure-specific endonuclease subunit SLX4-like. (234 aa)
tdp1tyrosyl-DNA phosphodiesterase 1. (607 aa)
brcc3Lys-63-specific deubiquitinase BRCC36. (260 aa)
LOC106532534Structure-specific endonuclease subunit SLX4-like. (1650 aa)
abl1Tyrosine-protein kinase. (1115 aa)
LOC106532596X-ray repair cross-complementing protein 5-like. (411 aa)
LOC106536681Ubiquitin-conjugating enzyme E2 variant 1-like. (170 aa)
LOC106536586Probable flap endonuclease 1 homolog. (346 aa)
LOC106536580RCC1 and BTB domain-containing protein 1-like. (531 aa)
baz1bTyrosine-protein kinase BAZ1B isoform X1. (1586 aa)
recql4ATP-dependent DNA helicase Q4. (1480 aa)
chek2Serine/threonine-protein kinase Chk2. (537 aa)
LOC106535981Cell cycle checkpoint control protein RAD9B-like. (395 aa)
exd2Exonuclease 3'-5' domain-containing protein 2. (669 aa)
dclre1cProtein artemis. (615 aa)
LOC106535502DNA-dependent protein kinase catalytic subunit-like; Belongs to the PI3/PI4-kinase family. (4105 aa)
rfc1Replication factor C subunit 1. (1170 aa)
LOC106535400DNA repair protein XRCC2-like. (288 aa)
tmem182Transmembrane protein 182. (235 aa)
LOC106535129E3 ubiquitin-protein ligase RNF168-like. (194 aa)
LOC106534679X-ray repair cross-complementing protein 6-like. (138 aa)
LOC106534592Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (808 aa)
eme1Crossover junction endonuclease EME1 isoform X1. (509 aa)
LOC106534377LOW QUALITY PROTEIN: histone H2B.3-like; Belongs to the histone H2B family. (66 aa)
atrSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2609 aa)
pole3DNA polymerase epsilon subunit 3. (150 aa)
rad17Cell cycle checkpoint protein RAD17. (632 aa)
spidrDNA repair-scaffolding protein. (610 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
LOC106533547Histone H2B; Belongs to the histone H2B family. (116 aa)
LOC106533484Serine/threonine-protein phosphatase 4 regulatory subunit 2-B-like. (91 aa)
LOC106533213Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa)
rfc2Replication factor C subunit 2. (346 aa)
pold4DNA polymerase delta subunit 4. (112 aa)
polkDNA polymerase kappa. (877 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC106510828Bromodomain adjacent to zinc finger domain protein 1A-like. (738 aa)
LOC106510870E3 ubiquitin-protein ligase RNF168-like. (421 aa)
rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
rad51cDNA repair protein RAD51 homolog 3. (348 aa)
LOC106511277Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (270 aa)
LOC106511409Poly [ADP-ribose] polymerase. (395 aa)
LOC106511709DNA repair protein XRCC2-like. (166 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (316 aa)
LOC106511871Structure-specific endonuclease subunit SLX4-like. (119 aa)
LOC106512025Checkpoint protein HUS1-like. (349 aa)
LOC106512407Checkpoint protein; Belongs to the HUS1 family. (285 aa)
LOC106512639Cell cycle checkpoint protein RAD17-like. (193 aa)
cdca7Cell division cycle-associated protein 7 isoform X1. (402 aa)
rbbp8DNA endonuclease RBBP8. (632 aa)
LOC106513019Histone H2B 1/2-like; Belongs to the histone H2B family. (111 aa)
dna2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1376 aa)
LOC106513356Ubiquitin-like. (85 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (614 aa)
polhDNA polymerase eta. (737 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
fam175aBRCA1-A complex subunit Abraxas. (354 aa)
tdrd3Tudor domain-containing protein 3. (787 aa)
chek1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (455 aa)
ccna1cyclin-A1; Belongs to the cyclin family. (406 aa)
rfc3Replication factor C subunit 3. (356 aa)
blmBloom syndrome protein isoform X1. (1417 aa)
lig3DNA ligase. (1012 aa)
rad51dDNA repair protein RAD51 homolog 4 isoform X1. (333 aa)
uimc1BRCA1-A complex subunit RAP80 isoform X1. (946 aa)
rad51ap1RAD51-associated protein 1 isoform X1. (306 aa)
pias4E3 SUMO-protein ligase PIAS4. (508 aa)
LOC106515271Small ubiquitin-related modifier. (96 aa)
mre11aDouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (694 aa)
LOC106515610Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
tdp2tyrosyl-DNA phosphodiesterase 2 isoform X1. (360 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (574 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (383 aa)
pold2DNA polymerase delta subunit 2. (471 aa)
babam1BRISC and BRCA1-A complex member 1 isoform X1. (429 aa)
brca1Breast cancer type 1 susceptibility protein. (1346 aa)
smarca5SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (1037 aa)
LOC106517127DNA-dependent protein kinase catalytic subunit-like; Belongs to the PI3/PI4-kinase family. (4105 aa)
rfc4Replication factor C subunit 4. (356 aa)
LOC106517370SUMO-conjugating enzyme UBC9-B; Belongs to the ubiquitin-conjugating enzyme family. (138 aa)
eme2Probable crossover junction endonuclease EME2 isoform X1. (434 aa)
topbp1DNA topoisomerase 2-binding protein 1. (1505 aa)
xrcc4DNA repair protein XRCC4. (293 aa)
LOC106517645Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (476 aa)
parp3Poly [ADP-ribose] polymerase. (583 aa)
timelessProtein timeless homolog. (1252 aa)
rad1Cell cycle checkpoint protein RAD1. (280 aa)
LOC106518264Serine/threonine-protein phosphatase 4 regulatory subunit 2-B-like. (422 aa)
LOC106518458Small ubiquitin-related modifier. (94 aa)
gen1Flap endonuclease GEN homolog 1. (818 aa)
breBRCA1-A complex subunit BRE. (386 aa)
pollDNA polymerase lambda; Belongs to the DNA polymerase type-X family. (568 aa)
LOC106518873Ubiquitin-like. (76 aa)
lig4DNA ligase. (909 aa)
LOC106519213Lysine-specific demethylase 4B-like. (1292 aa)
uba52ubiquitin-60S ribosomal protein L40. (128 aa)
LOC106519292Serine/threonine-protein phosphatase 4 regulatory subunit 2-A-like. (414 aa)
rfc5Replication factor C subunit 5. (335 aa)
whsc1Histone-lysine N-methyltransferase NSD2. (1298 aa)
kxd1kxDL motif-containing protein 1. (181 aa)
rad52DNA repair protein RAD52 homolog isoform X2. (426 aa)
slf1Ankyrin repeat domain-containing protein 32. (875 aa)
rcbtb2RCC1 and BTB domain-containing protein 2. (527 aa)
atmNon-specific serine/threonine protein kinase. (3066 aa)
ube2iSUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1014 aa)
parp2Poly [ADP-ribose] polymerase. (648 aa)
polqDNA polymerase theta isoform X1. (2713 aa)
mdc1Mediator of DNA damage checkpoint protein 1 isoform X1. (1884 aa)
rhno1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (289 aa)
paxip1PAX-interacting protein 1. (1049 aa)
LOC106521431Histone H2B; Belongs to the histone H2B family. (124 aa)
sirt7NAD-dependent protein deacetylase sirtuin-7. (409 aa)
brca2Breast cancer type 2 susceptibility protein. (3474 aa)
pole4DNA polymerase epsilon subunit 4 isoform X1. (128 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2287 aa)
LOC106521775Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
LOC106521853Putative ankyrin repeat domain-containing protein 31. (564 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
LOC106522150Serine-protein kinase ATM-like; Belongs to the PI3/PI4-kinase family. (391 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (522 aa)
palb2Partner and localizer of BRCA2. (1290 aa)
atripLOW QUALITY PROTEIN: ATR-interacting protein. (782 aa)
LOC106522875Transmembrane protein 182-like. (259 aa)
pold3DNA polymerase delta subunit 3. (437 aa)
xrcc5X-ray repair cross-complementing protein 5 isoform X1. (755 aa)
LOC106523318Small ubiquitin-related modifier. (94 aa)
LOC106523505Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
LOC106523691X-ray repair cross-complementing protein 5-like. (610 aa)
LOC106523874Importin subunit alpha; Belongs to the importin alpha family. (523 aa)
cnppd1Protein CNPPD1. (432 aa)
eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (650 aa)
rad50DNA repair protein RAD50. (1312 aa)
LOC106525098Histone H2B; Belongs to the histone H2B family. (124 aa)
rpa3Replication protein A 14 kDa subunit. (122 aa)
meiobMeiosis-specific with OB domain-containing protein. (463 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (355 aa)
exo1Exonuclease 1. (825 aa)
ankrd12Ankyrin repeat domain-containing protein 12 isoform X1. (1914 aa)
ccna2cyclin-A2; Belongs to the cyclin family. (435 aa)
LOC106526051DNA repair protein XRCC4-like isoform X1. (339 aa)
rmi1recQ-mediated genome instability protein 1. (690 aa)
rnf169E3 ubiquitin-protein ligase RNF169. (577 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
polmDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (506 aa)
sirt6NAD-dependent protein deacetylase sirtuin-6. (349 aa)
rif1Telomere-associated protein RIF1 isoform X1. (2335 aa)
mus81Crossover junction endonuclease MUS81 isoform X2. (596 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa)
rpa2Replication protein A 32 kDa subunit. (272 aa)
tp53bp1Tumor suppressor p53-binding protein 1. (1713 aa)
LOC106527012tyrosyl-DNA phosphodiesterase 2-like. (298 aa)
Your Current Organism:
Austrofundulus limnaeus
NCBI taxonomy Id: 52670
Other names: A. limnaeus
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