STRINGSTRING
recql4 recql4 LOC106536681 LOC106536681 LOC106536580 LOC106536580 LOC106535981 LOC106535981 LOC106535129 LOC106535129 LOC106534592 LOC106534592 LOC106534377 LOC106534377 atr atr rad17 rad17 ube2v2 ube2v2 LOC106533547 LOC106533547 LOC106533484 LOC106533484 LOC106533213 LOC106533213 rfc2 rfc2 brcc3 brcc3 LOC106529676 LOC106529676 LOC106529278 LOC106529278 ppp4c ppp4c rmi2 rmi2 LOC106527833 LOC106527833 LOC106527735 LOC106527735 tp53bp1 tp53bp1 rpa2 rpa2 sirt6 sirt6 rnf169 rnf169 rmi1 rmi1 ccna2 ccna2 ankrd12 ankrd12 exo1 exo1 rpa3 rpa3 LOC106525098 LOC106525098 rad50 rad50 LOC106523505 LOC106523505 LOC106523318 LOC106523318 atrip atrip rnf8 rnf8 LOC106522150 LOC106522150 sumo2 sumo2 LOC106521853 LOC106521853 LOC106521775 LOC106521775 LOC106521431 LOC106521431 rhno1 rhno1 mdc1 mdc1 top3a top3a ube2i ube2i atm atm rcbtb2 rcbtb2 whsc1 whsc1 rfc5 rfc5 LOC106519292 LOC106519292 bre bre LOC106518458 LOC106518458 LOC106518264 LOC106518264 rad1 rad1 timeless timeless topbp1 topbp1 LOC106517370 LOC106517370 rfc4 rfc4 brca1 brca1 babam1 babam1 rad9a rad9a kat5 kat5 LOC106515610 LOC106515610 mre11a mre11a LOC106515271 LOC106515271 pias4 pias4 uimc1 uimc1 blm blm rfc3 rfc3 ccna1 ccna1 fam175a fam175a dna2 dna2 rbbp8 rbbp8 LOC106512639 LOC106512639 LOC106512407 LOC106512407 LOC106512025 LOC106512025 tipin tipin LOC106510870 LOC106510870 cdk2 cdk2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
recql4ATP-dependent DNA helicase Q4. (1480 aa)
LOC106536681Ubiquitin-conjugating enzyme E2 variant 1-like. (170 aa)
LOC106536580RCC1 and BTB domain-containing protein 1-like. (531 aa)
LOC106535981Cell cycle checkpoint control protein RAD9B-like. (395 aa)
LOC106535129E3 ubiquitin-protein ligase RNF168-like. (194 aa)
LOC106534592Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (808 aa)
LOC106534377LOW QUALITY PROTEIN: histone H2B.3-like; Belongs to the histone H2B family. (66 aa)
atrSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2609 aa)
rad17Cell cycle checkpoint protein RAD17. (632 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
LOC106533547Histone H2B; Belongs to the histone H2B family. (116 aa)
LOC106533484Serine/threonine-protein phosphatase 4 regulatory subunit 2-B-like. (91 aa)
LOC106533213Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa)
rfc2Replication factor C subunit 2. (346 aa)
brcc3Lys-63-specific deubiquitinase BRCC36. (260 aa)
LOC106529676Uncharacterized protein LOC106529676. (373 aa)
LOC106529278RCC1 and BTB domain-containing protein 1-like isoform X1. (615 aa)
ppp4cSerine/threonine-protein phosphatase. (311 aa)
rmi2recQ-mediated genome instability protein 2. (147 aa)
LOC106527833Histone H2A; Belongs to the histone H2A family. (146 aa)
LOC106527735Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
tp53bp1Tumor suppressor p53-binding protein 1. (1713 aa)
rpa2Replication protein A 32 kDa subunit. (272 aa)
sirt6NAD-dependent protein deacetylase sirtuin-6. (349 aa)
rnf169E3 ubiquitin-protein ligase RNF169. (577 aa)
rmi1recQ-mediated genome instability protein 1. (690 aa)
ccna2cyclin-A2; Belongs to the cyclin family. (435 aa)
ankrd12Ankyrin repeat domain-containing protein 12 isoform X1. (1914 aa)
exo1Exonuclease 1. (825 aa)
rpa3Replication protein A 14 kDa subunit. (122 aa)
LOC106525098Histone H2B; Belongs to the histone H2B family. (124 aa)
rad50DNA repair protein RAD50. (1312 aa)
LOC106523505Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
LOC106523318Small ubiquitin-related modifier. (94 aa)
atripLOW QUALITY PROTEIN: ATR-interacting protein. (782 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (522 aa)
LOC106522150Serine-protein kinase ATM-like; Belongs to the PI3/PI4-kinase family. (391 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
LOC106521853Putative ankyrin repeat domain-containing protein 31. (564 aa)
LOC106521775Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
LOC106521431Histone H2B; Belongs to the histone H2B family. (124 aa)
rhno1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (289 aa)
mdc1Mediator of DNA damage checkpoint protein 1 isoform X1. (1884 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1014 aa)
ube2iSUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
atmNon-specific serine/threonine protein kinase. (3066 aa)
rcbtb2RCC1 and BTB domain-containing protein 2. (527 aa)
whsc1Histone-lysine N-methyltransferase NSD2. (1298 aa)
rfc5Replication factor C subunit 5. (335 aa)
LOC106519292Serine/threonine-protein phosphatase 4 regulatory subunit 2-A-like. (414 aa)
breBRCA1-A complex subunit BRE. (386 aa)
LOC106518458Small ubiquitin-related modifier. (94 aa)
LOC106518264Serine/threonine-protein phosphatase 4 regulatory subunit 2-B-like. (422 aa)
rad1Cell cycle checkpoint protein RAD1. (280 aa)
timelessProtein timeless homolog. (1252 aa)
topbp1DNA topoisomerase 2-binding protein 1. (1505 aa)
LOC106517370SUMO-conjugating enzyme UBC9-B; Belongs to the ubiquitin-conjugating enzyme family. (138 aa)
rfc4Replication factor C subunit 4. (356 aa)
brca1Breast cancer type 1 susceptibility protein. (1346 aa)
babam1BRISC and BRCA1-A complex member 1 isoform X1. (429 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (383 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (574 aa)
LOC106515610Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
mre11aDouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (694 aa)
LOC106515271Small ubiquitin-related modifier. (96 aa)
pias4E3 SUMO-protein ligase PIAS4. (508 aa)
uimc1BRCA1-A complex subunit RAP80 isoform X1. (946 aa)
blmBloom syndrome protein isoform X1. (1417 aa)
rfc3Replication factor C subunit 3. (356 aa)
ccna1cyclin-A1; Belongs to the cyclin family. (406 aa)
fam175aBRCA1-A complex subunit Abraxas. (354 aa)
dna2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1376 aa)
rbbp8DNA endonuclease RBBP8. (632 aa)
LOC106512639Cell cycle checkpoint protein RAD17-like. (193 aa)
LOC106512407Checkpoint protein; Belongs to the HUS1 family. (285 aa)
LOC106512025Checkpoint protein HUS1-like. (349 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (316 aa)
LOC106510870E3 ubiquitin-protein ligase RNF168-like. (421 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
Your Current Organism:
Austrofundulus limnaeus
NCBI taxonomy Id: 52670
Other names: A. limnaeus
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