(74 nodes) Cysteine and methionine metabolism network (Rhodotorula toruloides)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	BN2166_0032400	Aspartate/glutamate/uridylate kinase. (586 aa)
	BN2166_0073710	NAD-P-binding protein. (309 aa)
	BN2166_0068910	Belongs to the eIF-2B alpha/beta/delta subunits family. (563 aa)
	BN2166_0068610	annotation not available (497 aa)
	BN2166_0055420	FGENESH: predicted gene_11.38 protein. (247 aa)
	BN2166_0053420	Putative phosphoglycerate mutase family protein. (243 aa)
	BN2166_0053320	BY PROTMAP: gi\|472584245\|gb\|EMS21851.1\| cystathionine gamma-lyase [Rhodosporidium toruloides NP11]. (458 aa)
	BN2166_0068280	FGENESH: predicted gene_15.109 protein. (2428 aa)
	BN2166_0071040	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (392 aa)
	BN2166_0070790	Putative cystathionine gamma-synthase. (774 aa)
	BN2166_0050670	BY PROTMAP: gi\|647403126\|emb\|CDR49284.1\| RHTO0S25e00430g1_1 [Rhodosporidium toruloides]. (407 aa)
	BN2166_0074200	Serine dehydratase alpha chain-domain containing protein. (645 aa)
	BN2166_0063330	BY PROTMAP: gi\|342319504\|gb\|EGU11452.1\| Prefoldin subunit 3 [Rhodotorula glutinis ATCC 204091]. (348 aa)
	BN2166_0047770	Uncharacterized protein. (524 aa)
	BN2166_0046970	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (173 aa)
	BN2166_0046020	annotation not available (434 aa)
	BN2166_0063290	Belongs to the LDH/MDH superfamily. (334 aa)
	BN2166_0063190	annotation not available (453 aa)
	BN2166_0063140	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (317 aa)
	BN2166_0069150	annotation not available (474 aa)
	BN2166_0059180	BY PROTMAP: gi\|647397525\|emb\|CDR40601.1\| RHTO0S05e05358g1_1 [Rhodosporidium toruloides]. (473 aa)
	BN2166_0057930	Mismatched base pair and cruciform DNA recognition protein. (104 aa)
	MDE1	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (229 aa)
	BN2166_0042070	Homocysteine S-methyltransferase. (419 aa)
	BN2166_0065450	Major facilitator superfamily domain-containing protein. (465 aa)
	BN2166_0057190	Glutathione synthetase. (510 aa)
	BN2166_0039570	GAF domain-like protein. (213 aa)
	BN2166_0063700	Uncharacterized protein. (147 aa)
	BN2166_0056240	FGENESH: predicted gene_11.120 protein. (288 aa)
	BN2166_0051430	Belongs to the spermidine/spermine synthase family. (788 aa)
	BN2166_0059800	Uncharacterized protein. (284 aa)
	BN2166_0049630	O-acetylhomoserine ami. (435 aa)
	BN2166_0050640	BY PROTMAP: gi\|342321273\|gb\|EGU13207.1\| Homoserine dehydrogenase [Rhodotorula glutinis ATCC 204091]. (467 aa)
	BN2166_0050540	BY PROTMAP: gi\|647403143\|emb\|CDR49301.1\| RHTO0S25e00782g2_1 [Rhodosporidium toruloides]. (309 aa)
	BN2166_0056250	annotation not available (759 aa)
	BN2166_0045930	BY PROTMAP: gi\|647397094\|emb\|CDR39862.1\| RHTO0S04e11056g1_1 [Rhodosporidium toruloides]. (368 aa)
	BN2166_0030570	Yae1_N domain-containing protein. (348 aa)
	BN2166_0053550	annotation not available (195 aa)
	BN2166_0044690	FGENESH: predicted gene_8.324 protein. (447 aa)
	BN2166_0026820	Branched-chain amino acid aminotransferase II. (386 aa)
	BN2166_0041690	BY PROTMAP: gi\|342321638\|gb\|EGU13571.1\| Cysteine synthase [Rhodotorula glutinis ATCC 204091]. (379 aa)
	BN2166_0036230	Rhodanese-like domain-containing protein. (188 aa)
	BN2166_0034030	FGENESH: predicted gene_6.325 protein. (1018 aa)
	BN2166_0031910	annotation not available (441 aa)
	BN2166_0043200	annotation not available (1331 aa)
	BN2166_0042900	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1809 aa)
	BN2166_0042750	Pyridoxal phosphate-dependent transferase. (602 aa)
	BN2166_0030680	Major facilitator superfamily domain-containing protein. (473 aa)
	BN2166_0038950	annotation not available (420 aa)
	BN2166_0026360	FGENESH: predicted gene_5.181 protein. (417 aa)
	BN2166_0009870	BY PROTMAP: gi\|472580777\|gb\|EMS18550.1\| homoserine dehydrogenase [Rhodosporidium toruloides NP11]. (533 aa)
	BN2166_0009220	Glutamate-cysteine ligase-domain containing protein. (784 aa)
	BN2166_0034550	Pyridoxal phosphate-dependent transferase. (528 aa)
	BN2166_0026090	Pyridoxal phosphate-dependent transferase. (408 aa)
	BN2166_0024640	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (379 aa)
	BN2166_0021110	Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (706 aa)
	BN2166_0060720	Semialdehyde dehydrogenase, dimerization domain-domain containing protein. (363 aa)
	BN2166_0029250	Aspartate aminotransferase. (425 aa)
	BN2166_0017030	BY PROTMAP: gi\|647400349\|emb\|CDR45744.1\| RHTO0S11e04016g1_1 [Rhodosporidium toruloides]. (394 aa)
	BN2166_0018640	BY PROTMAP: gi\|342320074\|gb\|EGU12017.1\| Cysteine synthase [Rhodotorula glutinis ATCC 204091]. (970 aa)
	BN2166_0016940	annotation not available (293 aa)
	BN2166_0016640	annotation not available (344 aa)
	BN2166_0013590	annotation not available (493 aa)
	BN2166_0009360	annotation not available (435 aa)
	BN2166_0009430	annotation not available (383 aa)
	BN2166_0016950	FGENESH: predicted gene_3.146 protein. (127 aa)
	BN2166_0005030	Aspartate aminotransferase. (451 aa)
	BN2166_0003430	BY PROTMAP: gi\|342319389\|gb\|EGU11338.1\| Cystathionine beta-lyase [Rhodotorula glutinis ATCC 204091]. (2165 aa)
	BN2166_0002480	BY PROTMAP: gi\|647396872\|emb\|CDR39519.1\| RHTO0S04e05974g1_1 [Rhodosporidium toruloides]. (358 aa)
	BN2166_0002190	Pyridoxal phosphate-dependent transferase. (472 aa)
	BN2166_0006400	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (483 aa)
	BN2166_0007600	annotation not available (380 aa)
	BN2166_0000040	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (347 aa)
	BN2166_0070720	HAD-like domain-containing protein. (250 aa)

Your Current Organism:

Rhodotorula toruloides

NCBI taxonomy Id: 5286
Other names: CBS 6016, IFO 8766, IGC 5615, MUCL 28631, NRRL Y-6987, R. toruloides, Rhodosporidium toruloides, Rhodotorula gracilis, Rhodotorula rubescens, Rhodotorula toruloides (I. Banno) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout, 2015

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN2166_0000040	BN2166_0002190	A0A0K3C5N1	A0A0K3C691	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	Pyridoxal phosphate-dependent transferase.	0.768
BN2166_0000040	BN2166_0002480	A0A0K3C5N1	A0A0K3C6W5	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	BY PROTMAP: gi\|647396872\|emb\|CDR39519.1\| RHTO0S04e05974g1_1 [Rhodosporidium toruloides].	0.768
BN2166_0000040	BN2166_0021110	A0A0K3C5N1	A0A0K3CCG3	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family.	0.919
BN2166_0000040	BN2166_0024640	A0A0K3C5N1	A0A0K3CCG4	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.535
BN2166_0000040	BN2166_0046970	A0A0K3C5N1	A0A0K3CNT6	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	0.514
BN2166_0000040	BN2166_0068610	A0A0K3C5N1	A0A0K3CR99	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	annotation not available	0.476
BN2166_0000040	BN2166_0068910	A0A0K3C5N1	A0A0K3CRC6	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	Belongs to the eIF-2B alpha/beta/delta subunits family.	0.776
BN2166_0000040	MDE1	A0A0K3C5N1	A0A0K3CMM2	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).	0.745
BN2166_0002190	BN2166_0000040	A0A0K3C691	A0A0K3C5N1	Pyridoxal phosphate-dependent transferase.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.768
BN2166_0002190	BN2166_0005030	A0A0K3C691	A0A0K3C7K8	Pyridoxal phosphate-dependent transferase.	Aspartate aminotransferase.	0.519
BN2166_0002190	BN2166_0006400	A0A0K3C691	A0A0K3C567	Pyridoxal phosphate-dependent transferase.	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.632
BN2166_0002190	BN2166_0009870	A0A0K3C691	A0A0K3CD65	Pyridoxal phosphate-dependent transferase.	BY PROTMAP: gi\|472580777\|gb\|EMS18550.1\| homoserine dehydrogenase [Rhodosporidium toruloides NP11].	0.688
BN2166_0002190	BN2166_0024640	A0A0K3C691	A0A0K3CCG4	Pyridoxal phosphate-dependent transferase.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.842
BN2166_0002190	BN2166_0026820	A0A0K3C691	A0A0K3CHZ8	Pyridoxal phosphate-dependent transferase.	Branched-chain amino acid aminotransferase II.	0.578
BN2166_0002190	BN2166_0029250	A0A0K3C691	A0A0K3CBD2	Pyridoxal phosphate-dependent transferase.	Aspartate aminotransferase.	0.519
BN2166_0002190	BN2166_0031910	A0A0K3C691	A0A0K3CFP6	Pyridoxal phosphate-dependent transferase.	annotation not available	0.578
BN2166_0002190	BN2166_0032400	A0A0K3C691	A0A0K3CCC1	Pyridoxal phosphate-dependent transferase.	Aspartate/glutamate/uridylate kinase.	0.695
BN2166_0002190	BN2166_0034030	A0A0K3C691	A0A0K3CG41	Pyridoxal phosphate-dependent transferase.	FGENESH: predicted gene_6.325 protein.	0.578
BN2166_0002190	BN2166_0036230	A0A0K3C691	A0A0K3CGP4	Pyridoxal phosphate-dependent transferase.	Rhodanese-like domain-containing protein.	0.445
BN2166_0002190	BN2166_0042070	A0A0K3C691	A0A0K3CMF6	Pyridoxal phosphate-dependent transferase.	Homocysteine S-methyltransferase.	0.476

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