STRINGSTRING
purF purF purC purC AEH23925.1 AEH23925.1 pyrF pyrF pyrH pyrH AEH24270.1 AEH24270.1 pyrE pyrE AEH24314.1 AEH24314.1 AEH24315.1 AEH24315.1 purO purO AEH24360.1 AEH24360.1 AEH24410.1 AEH24410.1 pyrB pyrB pyrI pyrI pyrD pyrD AEH24456.1 AEH24456.1 AEH24477.1 AEH24477.1 AEH24517.1 AEH24517.1 AEH24518.1 AEH24518.1 AEH24666.1 AEH24666.1 upp upp guaAA guaAA guaAB guaAB purP purP AEH24884.1 AEH24884.1 AEH24998.1 AEH24998.1 guaB guaB pyrK pyrK pyrC pyrC purS purS purQ purQ purL purL purM purM purT purT purE purE purD purD AEH25273.1 AEH25273.1 AEH25345.1 AEH25345.1 AEH25396.1 AEH25396.1 purA purA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (444 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (234 aa)
AEH23925.1Adenine phosphoribosyltransferase. (237 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (211 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (236 aa)
AEH24270.1Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (315 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (184 aa)
AEH24314.1Phosphoribosylaminoimidazolesuccinocarboxamide synthase. (219 aa)
AEH24315.15-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl. (310 aa)
purOIMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (196 aa)
AEH24360.1Aspartate racemase. (226 aa)
AEH24410.1Asparagine synthase. (487 aa)
pyrBAspartate carbamoyltransferase catalytic subunit. (308 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (151 aa)
pyrDDihydroorotate dehydrogenase 1B; Catalyzes the conversion of dihydroorotate to orotate. (298 aa)
AEH24456.1Arylmalonate decarboxylase. (236 aa)
AEH24477.1Carbamate kinase; Belongs to the carbamate kinase family. (314 aa)
AEH24517.1ferredoxin-NADP(+) reductase subunit alpha. (289 aa)
AEH24518.1Putative oxidoreductase. (472 aa)
AEH24666.1Uracil/xanthine permease. (423 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (232 aa)
guaAAGMP synthase subunit A; Catalyzes the synthesis of GMP from XMP. (188 aa)
guaABGMP synthase subunit B; Catalyzes the synthesis of GMP from XMP. (307 aa)
purP5-aminoimidazole-4-carboxamide-1-beta-D- ribofuranosyl; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (331 aa)
AEH24884.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (450 aa)
AEH24998.1HAM1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (184 aa)
guaBInosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (244 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (408 aa)
purSPhosphoribosylformylglycinamidine synthase, purS protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (80 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (216 aa)
purLPhosphoribosylformylglycinamidine synthase II, purL component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is th [...] (707 aa)
purMPhosphoribosylaminoimidazole synthetase. (333 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (429 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (143 aa)
purDPhosphoribosylamine--glycine ligase (purD); Belongs to the GARS family. (438 aa)
AEH25273.15-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl. (380 aa)
AEH25345.1L-asparaginase. (306 aa)
AEH25396.1L-asparaginase. (328 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (339 aa)
Your Current Organism:
Pyrococcus yayanosii
NCBI taxonomy Id: 529709
Other names: P. yayanosii CH1, Pyrococcus sp. CH1, Pyrococcus yayanosii CH1, Pyrococcus yayanosii str. CH1, Pyrococcus yayanosii strain CH1
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