STRINGSTRING
endA endA pckG pckG AEH25157.1 AEH25157.1 moaA moaA AEH25310.1 AEH25310.1 speH speH AEH25436.1 AEH25436.1 nnrD nnrD rbcL rbcL fbp fbp moaC moaC taw1 taw1 AEH23957.1 AEH23957.1 pyrF pyrF nth nth AEH24091.1 AEH24091.1 AEH24138.1 AEH24138.1 pdaD pdaD AEH24224.1 AEH24224.1 AEH24271.1 AEH24271.1 mfnA mfnA thiC thiC AEH24358.1 AEH24358.1 AEH24359.1 AEH24359.1 AEH24379.1 AEH24379.1 AEH24434.1 AEH24434.1 cobD cobD AEH24553.1 AEH24553.1 AEH24593.1 AEH24593.1 AEH24622.1 AEH24622.1 dacZ dacZ queE queE AEH24730.1 AEH24730.1 pdxT pdxT pdxS pdxS AEH24788.1 AEH24788.1 AEH24789.1 AEH24789.1 AEH24790.1 AEH24790.1 AEH24801.1 AEH24801.1 AEH24821.1 AEH24821.1 AEH24884.1 AEH24884.1 eno eno AEH24973.1 AEH24973.1 AEH24978.1 AEH24978.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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endAtRNA-splicing endonuclease subunit alpha; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (175 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (628 aa)
AEH25157.1Fructose 1,6-bisphosphate aldolase class 1 (fba). (281 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (306 aa)
AEH25310.1L-fuculose 1-phosphate aldolase (fucA). (187 aa)
speHS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (140 aa)
AEH25436.1dTDP-glucose 4,6-dehydratase. (333 aa)
nnrDYjeF-like carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family. (480 aa)
rbcLRibulose bisophosphate carboxylase; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (421 aa)
fbpThermophile-specific fructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (374 aa)
moaCPutative molybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (154 aa)
taw1tRNA-modifying enzyme; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (326 aa)
AEH23957.1Enolase. (341 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (211 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (234 aa)
AEH24091.13-octaprenyl-4-hydroxybenzoate decarboxylyase. (420 aa)
AEH24138.1Hypothetical protein. (133 aa)
pdaDPyruvoyl-dependent arginine decarboxylase; Belongs to the PdaD family. (158 aa)
AEH24224.1Metal-dependent hydrolase. (252 aa)
AEH24271.1methylmalonyl-CoA decarboxylase beta chain. (400 aa)
mfnAL-tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (383 aa)
thiCThiamine biosynthesis protein (thiC); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (430 aa)
AEH24358.1Fumarate hydratase. (278 aa)
AEH24359.1Fumarate hydratase. (175 aa)
AEH24379.1N-glycosylase/DNA lyase; DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double- stranded DNA substrates. (266 aa)
AEH24434.1Hypothetical protein. (137 aa)
cobDCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (288 aa)
AEH24553.1Cystathionine gamma-lyase. (387 aa)
AEH24593.1Cystathionine gamma-lyase. (385 aa)
AEH24622.1Adenylyl cyclase, CyaB-type, putative. (176 aa)
dacZHypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. (266 aa)
queEOrganic radical activating enzyme, radical SAM superfamily; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (253 aa)
AEH24730.16-pyruvoyl-tetrahydropterin synthase. (115 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (197 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (335 aa)
AEH24788.1Formate hydrogenlyase II subunit D. (684 aa)
AEH24789.1Formate hydrogenlyase II subunit E. (308 aa)
AEH24790.1Formate hydrogenlyase II subunit F. (575 aa)
AEH24801.1Membrane bound complex 1, subunit A. (521 aa)
AEH24821.1Bifunctional phosphopantothenoylcysteine. (407 aa)
AEH24884.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (450 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
AEH24973.1Putative 6-pyruvoyl tetrahydrobiopterin synthase. (149 aa)
AEH24978.1Hypothetical protein. (265 aa)
Your Current Organism:
Pyrococcus yayanosii
NCBI taxonomy Id: 529709
Other names: P. yayanosii CH1, Pyrococcus sp. CH1, Pyrococcus yayanosii CH1, Pyrococcus yayanosii str. CH1, Pyrococcus yayanosii strain CH1
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