STRINGSTRING
OTP27971.1 OTP27971.1 raiA raiA rpsU rpsU OTP27892.1 OTP27892.1 recO recO rpsP rpsP araD araD rpmG-2 rpmG-2 OTP27768.1 OTP27768.1 OTP27755.1 OTP27755.1 OTP27754.1 OTP27754.1 OTP27677.1 OTP27677.1 rpmG rpmG OTP27626.1 OTP27626.1 rpsB rpsB OTP27587.1 OTP27587.1 DnaB2 DnaB2 DnaI DnaI rpsN rpsN rpmF-2 rpmF-2 OTP27414.1 OTP27414.1 OTP27413.1 OTP27413.1 OTP27411.1 OTP27411.1 OTP27410.1 OTP27410.1 OTP27409.1 OTP27409.1 OTP27408.1 OTP27408.1 OTP27407.1 OTP27407.1 OTP27405.1 OTP27405.1 OTP27404.1 OTP27404.1 OTP27403.1 OTP27403.1 OTP27402.1 OTP27402.1 OTP27400.1 OTP27400.1 OTP27399.1 OTP27399.1 OTP27394.1 OTP27394.1 OTP27259.1 OTP27259.1 cshB cshB nth nth DnaD DnaD rpsT rpsT OTP27092.1 OTP27092.1 RecQ2 RecQ2 parE parE topA topA OTP26936.1 OTP26936.1 OTP26888.1 OTP26888.1 HupA HupA rpsE rpsE rplR rplR rpsH rpsH rpsN-2 rpsN-2 rplE rplE rplN rplN rpsQ rpsQ rpmC rpmC rpsC rpsC rpsS rpsS rplB rplB rplW rplW rplC rplC rpsJ rpsJ rpsG rpsG OTP25185.1 OTP25185.1 rpsR rpsR rpsF rpsF gyrB gyrB recF recF rpmH rpmH Spo0J Spo0J ackA ackA OTP28537.1 OTP28537.1 dtd dtd OTP28505.1 OTP28505.1 cutC cutC rpmG-3 rpmG-3 rplK rplK rplA rplA rplJ rplJ rplL rplL OTP28297.1 OTP28297.1 OTP28287.1 OTP28287.1 OTP28216.1 OTP28216.1 rplO rplO rpmJ rpmJ rpsK rpsK rplQ rplQ rpmB rpmB smc smc OTP25351.1 OTP25351.1 rpsO rpsO rplY rplY udk udk cshA cshA rpmI rpmI OTP25534.1 OTP25534.1 rhaD rhaD rplM rplM rpsI rpsI OTP24965.1 OTP24965.1 OTP24966.1 OTP24966.1 priA priA OTP25052.1 OTP25052.1 Dus Dus OTP22125.1 OTP22125.1 OTP22138.1 OTP22138.1 OTP22163.1 OTP22163.1 OTP22176.1 OTP22176.1 OTP19991.1 OTP19991.1 OTP20004.1 OTP20004.1 OTP20029.1 OTP20029.1 OTP20042.1 OTP20042.1 OTP19936.1 OTP19936.1 OTP28000.1 OTP28000.1 trxA trxA OTP28173.1 OTP28173.1 EutN EutN OTP28177.1 OTP28177.1 EutK EutK OTP28181.1 OTP28181.1 EutL EutL EutC EutC EutA EutA OTP28188.1 OTP28188.1 OTP28190.1 OTP28190.1 EutP EutP rpmD rpmD RpsA RpsA OTP26881.1 OTP26881.1 dnaG dnaG rpmF rpmF OTP26710.1 OTP26710.1 OTP26704.1 OTP26704.1 OTP26670.1 OTP26670.1 OTP26660.1 OTP26660.1 recN recN rpmA rpmA rplU rplU recR recR OTP26590.1 OTP26590.1 OTP26588.1 OTP26588.1 OTP26586.1 OTP26586.1 rpmE2 rpmE2 OTP26565.1 OTP26565.1 OTP26558.1 OTP26558.1 ezrA ezrA OTP26540.1 OTP26540.1 OTP26523.1 OTP26523.1 rnmV rnmV OTP26465.1 OTP26465.1 OTP26427.1 OTP26427.1 OTP26406.1 OTP26406.1 OTP26345.1 OTP26345.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OTP27971.1Integral membrane protein. (192 aa)
raiARibosomal subunit interface protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (183 aa)
rpsU30S ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (58 aa)
OTP27892.1Diacylglycerol kinase. (137 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (267 aa)
rpsP30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (91 aa)
araDL-ribulose-5-phosphate 4-epimerase. (232 aa)
rpmG-250S ribosomal protein L33 3; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
OTP27768.1Helix-turn-helix protein. (103 aa)
OTP27755.1Hypothetical protein. (260 aa)
OTP27754.1Hypothetical protein. (282 aa)
OTP27677.1Hypothetical protein. (120 aa)
rpmG50S ribosomal protein L33 3; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
OTP27626.1Hypothetical protein. (297 aa)
rpsB30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (260 aa)
OTP27587.150S ribosomal protein L7Ae. (103 aa)
DnaB2Hypothetical protein. (460 aa)
DnaIPrimosomal protein DnaI. (308 aa)
rpsN30S ribosomal protein S14 1; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (89 aa)
rpmF-250S ribosomal protein; Belongs to the bacterial ribosomal protein bL32 family. (55 aa)
OTP27414.1Hypothetical protein. (117 aa)
OTP27413.1Ethanolamine utilization protein, EutP. (144 aa)
OTP27411.1Propanediol utilization protein PduA. (93 aa)
OTP27410.1Propanediol utilization protein PduB. (269 aa)
OTP27409.1Propanediol dehydratase large subunit. (553 aa)
OTP27408.1Diol dehydrase (diol dehydratase) gamma subunit; Propanediol dehydratase medium subunit. (225 aa)
OTP27407.1Hypothetical protein. (168 aa)
OTP27405.1Hypothetical protein. (119 aa)
OTP27404.1Hypothetical protein. (172 aa)
OTP27403.1Propanediol utilization protein PduA. (93 aa)
OTP27402.1Hypothetical protein. (208 aa)
OTP27400.1Hypothetical protein. (161 aa)
OTP27399.1Hypothetical protein. (87 aa)
OTP27394.1Acetate kinase. (396 aa)
OTP27259.1DNA topoisomerase III. (723 aa)
cshBDEAD/DEAH box helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (449 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (221 aa)
DnaDDNA replication protein. (234 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (84 aa)
OTP27092.1ComE operon protein 2. (160 aa)
RecQ2ATP-dependent DNA helicase RecQ. (595 aa)
parEDNA topoisomerase 4 subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (681 aa)
topADNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (692 aa)
OTP26936.1Hypothetical protein. (318 aa)
OTP26888.1Hypothetical protein. (419 aa)
HupADNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (91 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (166 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsN-230S ribosomal protein S14 type Z; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (88 aa)
rpmC50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (62 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (218 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (276 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (96 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (209 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
OTP25185.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (455 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (99 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (648 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (371 aa)
rpmH50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
Spo0JChromosome partitioning protein ParB; Belongs to the ParB family. (296 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (393 aa)
OTP28537.1Recombination factor protein RarA. (426 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa)
OTP28505.1Snf2 family protein. (1064 aa)
cutCCopper homeostasis protein CutC; Participates in the control of copper homeostasis. Belongs to the CutC family. (213 aa)
rpmG-350S ribosomal protein L33 2; Belongs to the bacterial ribosomal protein bL33 family. (50 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (140 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (167 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
OTP28297.1Hypothetical protein. (112 aa)
OTP28287.1Hypothetical protein. (250 aa)
OTP28216.1ATP:cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (174 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
rpmJ50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (38 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rplQ50S ribosomal protein L17. (126 aa)
rpmB50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (62 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1193 aa)
OTP25351.1NAD-dependent deacetylase. (238 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
rplYRibosomal protein L25, Ctc-form; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (202 aa)
udkUridine kinase. (209 aa)
cshADEAD/DEAH box helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (511 aa)
rpmI50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
OTP25534.1Class II aldolase and adducin protein. (250 aa)
rhaDRhamnulose-1-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (274 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (174 aa)
rpsI30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa)
OTP24965.1tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (321 aa)
OTP24966.1crtN; Dehydrosqualene desaturase. (496 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (802 aa)
OTP25052.1S1 RNA-binding protein. (156 aa)
DustRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (332 aa)
OTP22125.1repA; Replication initiator protein A. (346 aa)
OTP22138.1Fimbrial isopeptide formation D2 domain-containing protein. (696 aa)
OTP22163.1DNA topoisomerase III. (734 aa)
OTP22176.1Hypothetical protein. (413 aa)
OTP19991.1repA; Replication initiator protein A. (346 aa)
OTP20004.1Fimbrial isopeptide formation D2 domain-containing protein. (696 aa)
OTP20029.1DNA topoisomerase III. (734 aa)
OTP20042.1Hypothetical protein. (413 aa)
OTP19936.1Hypothetical protein. (915 aa)
OTP28000.1HD protein. (456 aa)
trxAThioredoxin; Belongs to the thioredoxin family. (104 aa)
OTP28173.1Ethanolamine utilization protein EutQ. (147 aa)
EutNEthanolamine utilization protein EutN. (86 aa)
OTP28177.1Phosphate propanoyltransferase. (207 aa)
EutKPropanediol utilization protein PduA. (94 aa)
OTP28181.1Hypothetical protein. (165 aa)
EutLEthanolamine utilization protein EutL. (217 aa)
EutCEthanolamine ammonia-lyase light chain. (305 aa)
EutAeutA; Ethanolamine utilization protein EutA family protein. (474 aa)
OTP28188.1Propanediol utilization protein PduU. (115 aa)
OTP28190.1ATP:cob(I)alamin adenosyltransferase. (193 aa)
EutPEthanolamine utilization protein, EutP. (139 aa)
rpmD50S ribosomal protein L30. (59 aa)
RpsARibosomal protein S1. (408 aa)
OTP26881.1Hypothetical protein. (463 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (613 aa)
rpmF50S ribosomal protein; Belongs to the bacterial ribosomal protein bL32 family. (59 aa)
OTP26710.1UDP-glucose 4-epimerase. (318 aa)
OTP26704.1NAD dependent epimerase/dehydratase. (351 aa)
OTP26670.1Hypothetical protein. (425 aa)
OTP26660.1S4 domain-containing protein. (260 aa)
recNDNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (559 aa)
rpmA50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (97 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
OTP26590.1Nucleoid-associated protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (103 aa)
OTP26588.1Hypothetical protein. (415 aa)
OTP26586.1Hypothetical protein. (267 aa)
rpmE250S ribosomal protein L31 type B. (87 aa)
OTP26565.1Carbonic anhydrase/acetyltransferase. (162 aa)
OTP26558.1DNA repair protein RadC; Belongs to the UPF0758 family. (183 aa)
ezrASeptation ring formation regulator EzrA; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (573 aa)
OTP26540.1General stress protein. (126 aa)
OTP26523.1Phosphoesterase RecJ protein. (316 aa)
rnmVRibonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. (189 aa)
OTP26465.1DNA topoisomerase III. (657 aa)
OTP26427.1Two-component system sensor histidine kinase. (341 aa)
OTP26406.1Hypothetical protein. (417 aa)
OTP26345.1Hypothetical protein. (498 aa)
Your Current Organism:
Enterococcus mundtii
NCBI taxonomy Id: 53346
Other names: ATCC 43186, CCUG 18656, CFBP 4251, CIP 103010, DSM 4838, E. mundtii, Enterobacter sp. PX-E.sp.Jor, JCM 8731, LMG 10748, LMG:10748, MUTK 559, NBRC 100490, NCDO 2375, NCIMB 702375, NCTC 12363
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