(35 nodes) Pyrimidine metabolism, and Glutamate biosynthetic process network (Clostridium carboxidivorans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AKN29759.1	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
	AKN30126.1	NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
	AKN30127.1	Dihydropyrimidine dehydrogenase; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
	carB	Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1068 aa)
	carA	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
	AKN31691.1	Allantoate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
	AKN31692.1	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
	AKN31694.1	Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
	AKN31695.1	Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
	AKN31779.1	Carbamate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
	AKN32221.1	Dihydropyrimidine dehydrogenase; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
	AKN32222.1	NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
	AKN32224.1	Carbamate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbamate kinase family. (314 aa)
	AKN32500.1	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1499 aa)
	AKN32689.1	Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1062 aa)
	carA-2	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
	pyrE	Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (193 aa)
	pyrD	Diguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate. (297 aa)
	pyrK	Diguanylate cyclase; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (246 aa)
	pyrF	Orotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (290 aa)
	pyrC	Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (394 aa)
	AKN32696.1	Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
	pyrB	Aspartate carbamoyltransferase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa)
	AKN32746.1	NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
	AKN32747.1	Dihydropyrimidine dehydrogenase; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
	AKN32748.1	NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
	AKN33208.1	Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (332 aa)
	AKN33670.1	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
	AKN33671.1	Nitrate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (514 aa)
	AKN33672.1	Allantoate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
	AKN33679.1	Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
	AKN33680.1	Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
	pyrR	Bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (177 aa)
	AKN34001.1	Uracil permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
	AKN34073.1	NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)

Your Current Organism:

Clostridium carboxidivorans

NCBI taxonomy Id: 536227
Other names: C. carboxidivorans P7, Clostridium carboxidivorans P7, Clostridium carboxidivorans str. P7, Clostridium carboxidivorans strain P7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKN29759.1	AKN30126.1	Ccar_02405	Ccar_04520	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.740
AKN29759.1	AKN31691.1	Ccar_02405	Ccar_12805	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Allantoate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.861
AKN29759.1	AKN31692.1	Ccar_02405	Ccar_12810	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.979
AKN29759.1	AKN31694.1	Ccar_02405	Ccar_12820	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.924
AKN29759.1	AKN31695.1	Ccar_02405	Ccar_12825	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.950
AKN29759.1	AKN32222.1	Ccar_02405	Ccar_15680	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.740
AKN29759.1	AKN32689.1	Ccar_02405	Ccar_18275	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.633
AKN29759.1	AKN32696.1	Ccar_02405	Ccar_18310	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.459
AKN29759.1	AKN32746.1	Ccar_02405	Ccar_18635	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.738
AKN29759.1	AKN32748.1	Ccar_02405	Ccar_18645	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.739
AKN29759.1	AKN33670.1	Ccar_02405	Ccar_23745	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.980
AKN29759.1	AKN33672.1	Ccar_02405	Ccar_23755	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Allantoate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.862
AKN29759.1	AKN33679.1	Ccar_02405	Ccar_23790	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.951
AKN29759.1	AKN33680.1	Ccar_02405	Ccar_23795	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.925
AKN29759.1	AKN34001.1	Ccar_02405	Ccar_25470	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Uracil permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.474
AKN29759.1	AKN34073.1	Ccar_02405	Ccar_25845	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.744
AKN29759.1	carA	Ccar_02405	Ccar_09850	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.599
AKN29759.1	carA-2	Ccar_02405	Ccar_18280	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.591
AKN29759.1	carB	Ccar_02405	Ccar_09845	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family.	0.640
AKN29759.1	pyrB	Ccar_02405	Ccar_18315	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aspartate carbamoyltransferase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.	0.731

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