STRINGSTRING
smc smc AKN29453.1 AKN29453.1 AKN29454.1 AKN29454.1 topA topA AKN29482.1 AKN29482.1 recA recA AKN29507.1 AKN29507.1 polC polC AKN29747.1 AKN29747.1 AKN29767.1 AKN29767.1 AKN29769.1 AKN29769.1 AKN29818.1 AKN29818.1 AKN29857.1 AKN29857.1 AKN29913.1 AKN29913.1 AKN29953.1 AKN29953.1 AKN30000.1 AKN30000.1 AKN30038.1 AKN30038.1 AKN30289.1 AKN30289.1 AKN30330.1 AKN30330.1 AKN30628.1 AKN30628.1 AKN30633.1 AKN30633.1 dinB dinB lexA lexA mutL mutL AKN30676.1 AKN30676.1 AKN30687.1 AKN30687.1 AKN30690.1 AKN30690.1 sbcD sbcD AKN30763.1 AKN30763.1 AKN30793.1 AKN30793.1 AKN30832.1 AKN30832.1 AKN30872.1 AKN30872.1 AKN31179.1 AKN31179.1 AKN31656.1 AKN31656.1 topB topB AKN32073.1 AKN32073.1 polA polA AKN32415.1 AKN32415.1 AKN32416.1 AKN32416.1 AKN32582.1 AKN32582.1 AKN32583.1 AKN32583.1 AKN32625.1 AKN32625.1 AKN32626.1 AKN32626.1 AKN32627.1 AKN32627.1 AKN32628.1 AKN32628.1 AKN32836.1 AKN32836.1 AKN32859.1 AKN32859.1 uvrC uvrC uvrA uvrA AKN32872.1 AKN32872.1 AKN33118.1 AKN33118.1 AKN33125.1 AKN33125.1 AKN33126.1 AKN33126.1 AKN33127.1 AKN33127.1 AKN33128.1 AKN33128.1 AKN33129.1 AKN33129.1 rsmG rsmG mnmG mnmG mnmE mnmE AKN33135.1 AKN33135.1 rnpA rnpA dnaA dnaA AKN33139.1 AKN33139.1 AKN33140.1 AKN33140.1 recF recF AKN33142.1 AKN33142.1 gyrB gyrB gyrA gyrA dnaX dnaX AKN33193.1 AKN33193.1 nth nth AKN33460.1 AKN33460.1 AKN33611.1 AKN33611.1 AKN33635.1 AKN33635.1 AKN33774.1 AKN33774.1 gyrB-2 gyrB-2 AKN33883.1 AKN33883.1 AKN33892.1 AKN33892.1 AKN33938.1 AKN33938.1 scpA scpA scpB scpB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1188 aa)
AKN29453.1AP endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
AKN29454.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (701 aa)
AKN29482.1Cell division protein FtsK; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FtsK/SpoIIIE/SftA family. (754 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (358 aa)
AKN29507.1LexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response). (487 aa)
polCDNA polymerase III subunit alpha; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1449 aa)
AKN29747.1DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (775 aa)
AKN29767.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (736 aa)
AKN29769.1Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
AKN29818.1DNA mismatch repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (627 aa)
AKN29857.1UvrABC system subunit C; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
AKN29913.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (862 aa)
AKN29953.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
AKN30000.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (748 aa)
AKN30038.1Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (261 aa)
AKN30289.1Daunorubicin resistance protein DrrC; Derived by automated computational analysis using gene prediction method: Protein Homology. (746 aa)
AKN30330.1Pseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RsuA family. (263 aa)
AKN30628.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (711 aa)
AKN30633.1ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (762 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (397 aa)
lexALexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (202 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (633 aa)
AKN30676.1DNA mismatch repair protein MutS; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA mismatch repair MutS family. (903 aa)
AKN30687.1Pseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RsuA family. (234 aa)
AKN30690.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1050 aa)
sbcDDNA repair exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (387 aa)
AKN30763.1Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
AKN30793.1DNA mismatch repair protein MutS; Derived by automated computational analysis using gene prediction method: Protein Homology. (560 aa)
AKN30832.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
AKN30872.1DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1034 aa)
AKN31179.1Cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (156 aa)
AKN31656.13'-5' exonuclease of DNA polymerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
topBDNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (731 aa)
AKN32073.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (880 aa)
AKN32415.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (600 aa)
AKN32416.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (715 aa)
AKN32582.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
AKN32583.1Zinc finger CHC2-family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
AKN32625.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
AKN32626.1AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
AKN32627.1Cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (147 aa)
AKN32628.1DNA-3-methyladenine glycosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
AKN32836.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (710 aa)
AKN32859.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1192 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (622 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (940 aa)
AKN32872.1The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; Derived by automated computational analysis using gene prediction method: Protein Homology. (661 aa)
AKN33118.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (148 aa)
AKN33125.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
AKN33126.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
AKN33127.1Plasmid stablization protein ParB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ParB family. (288 aa)
AKN33128.1Sporulation initiation inhibitor Soj; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
AKN33129.1Chromosome partitioning protein ParB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ParB family. (258 aa)
rsmG16S rRNA methyltransferase; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (239 aa)
mnmGtRNA uridine 5-carboxymethylaminomethyl modification protein; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (629 aa)
mnmEtRNA modification GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (459 aa)
AKN33135.1Membrane protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. (69 aa)
rnpARibonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (110 aa)
dnaAChromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (450 aa)
AKN33139.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (367 aa)
AKN33140.1RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
recFRecombinase RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (363 aa)
AKN33142.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (87 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (637 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (823 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (541 aa)
AKN33193.1DNA polymerase III subunit delta; Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (212 aa)
AKN33460.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa)
AKN33611.1DNA mismatch repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA mismatch repair MutS family. (605 aa)
AKN33635.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
AKN33774.1ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (666 aa)
gyrB-2DNA gyrase subunit B; Negatively supercoils closed circular double-stranded DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (653 aa)
AKN33883.1DNA topoisomerase IV subunit A; Decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; Derived by automated computational analysis using gene prediction method: Protein Homology. (959 aa)
AKN33892.1Recombinase RecJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (592 aa)
AKN33938.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
scpASegregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. (253 aa)
scpBSegregation and condensation protein B; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (196 aa)
Your Current Organism:
Clostridium carboxidivorans
NCBI taxonomy Id: 536227
Other names: C. carboxidivorans P7, Clostridium carboxidivorans P7, Clostridium carboxidivorans str. P7, Clostridium carboxidivorans strain P7
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