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AKN33087.1 AKN33087.1 purA-2 purA-2 AKN33263.1 AKN33263.1 pyrG pyrG upp upp atpB atpB atpE atpE AKN33309.1 AKN33309.1 atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC AKN33334.1 AKN33334.1 pgk pgk tpiA tpiA gpmI gpmI eno eno deoB deoB surE surE AKN33674.1 AKN33674.1 AKN33675.1 AKN33675.1 purE purE purC purC purF purF purM purM purN purN purH purH purD purD AKN33735.1 AKN33735.1 AKN33819.1 AKN33819.1 AKN33952.1 AKN33952.1 AKN34041.1 AKN34041.1 AKN34059.1 AKN34059.1 AKN33086.1 AKN33086.1 accA accA prs prs AKN33031.1 AKN33031.1 AKN33022.1 AKN33022.1 coaX coaX adk adk AKN32932.1 AKN32932.1 AKN32931.1 AKN32931.1 dacA dacA pfkA pfkA AKN32857.1 AKN32857.1 AKN32778.1 AKN32778.1 AKN32776.1 AKN32776.1 guaB guaB guaA guaA pgi pgi pyrB pyrB pyrF pyrF pyrK pyrK pyrD pyrD pyrE pyrE carA-2 carA-2 AKN32689.1 AKN32689.1 AKN32494.1 AKN32494.1 apt apt AKN32472.1 AKN32472.1 AKN32438.1 AKN32438.1 AKN32437.1 AKN32437.1 AKN32349.1 AKN32349.1 coaE coaE AKN32068.1 AKN32068.1 AKN32067.1 AKN32067.1 AKN32046.1 AKN32046.1 AKN31670.1 AKN31670.1 AKN31604.1 AKN31604.1 AKN31288.1 AKN31288.1 purA purA carA carA carB carB AKN30963.1 AKN30963.1 AKN30824.1 AKN30824.1 AKN30572.1 AKN30572.1 AKN30571.1 AKN30571.1 AKN30565.1 AKN30565.1 AKN30412.1 AKN30412.1 xpt xpt AKN30345.1 AKN30345.1 AKN30299.1 AKN30299.1 AKN29985.1 AKN29985.1 AKN29650.1 AKN29650.1 AKN29627.1 AKN29627.1 AKN29494.1 AKN29494.1 AKN29475.1 AKN29475.1 pyrH pyrH ackA ackA AKN29431.1 AKN29431.1 coaD coaD AKN29411.1 AKN29411.1 gmk gmk udk udk
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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AKN33087.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
purA-2Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
AKN33263.11-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
atpBATP synthase F0F1 subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (227 aa)
atpEATP F0F1 synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa)
AKN33309.1ATP F0F1 synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATPase B chain family. (159 aa)
atpHATP synthase F0F1 subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (179 aa)
atpAATP F0F1 synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (504 aa)
atpGATP synthase F0F1 subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (283 aa)
atpDATP F0F1 synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (466 aa)
atpCATP synthase F0F1 subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (132 aa)
AKN33334.1GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (397 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (507 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (393 aa)
surEStationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (249 aa)
AKN33674.1beta-alanyl-CoA:ammonia lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
AKN33675.1acyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (479 aa)
purMPhosphoribosylaminoimidazole synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (203 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
purDPhosphoribosylamine--glycine ligase; Catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (415 aa)
AKN33735.1acyl-CoA thioester hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
AKN33819.1Lactoylglutathione lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
AKN33952.1ATP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
AKN34041.1ADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
AKN34059.1Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. (329 aa)
AKN33086.1acetyl-CoA carboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
accAacetyl-CoA carboxylase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (281 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
AKN33031.1Nucleotide pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
AKN33022.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (259 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
AKN32932.1Citrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
AKN32931.1citrate-ACP transferase, the alpha subunit catalyzes the formation of (3S)-citryl-CoA from acetyl-CoA and citrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
dacAMembrane protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (282 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
AKN32857.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (584 aa)
AKN32778.1acetyl-CoA synthase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
AKN32776.1Bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; In acetogenic organisms, this enzyme complex converts carbon dioxide to acetyl-CoA while in methanogenic organisms this enzyme is used to degrade acetyl-CoA to form methane and carbon dioxide; part of an enzyme complex; Derived by automated computational analysis using gene prediction method: Protein Homology. (708 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (510 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (449 aa)
pyrBAspartate carbamoyltransferase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (290 aa)
pyrKDiguanylate cyclase; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (246 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate. (297 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (193 aa)
carA-2Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
AKN32689.1Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1062 aa)
AKN32494.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (173 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
AKN32472.1(p)ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (724 aa)
AKN32438.1Citrate lyase subunit beta; citryl-ACP lyase; catalyzes the formation of acetate and oxaloacetate from citrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HpcH/HpaI aldolase family. (295 aa)
AKN32437.1citrate-ACP transferase, the alpha subunit catalyzes the formation of (3S)-citryl-CoA from acetyl-CoA and citrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (510 aa)
AKN32349.1Topology modulation protein; In Listeria monocytogenes this protein binds a specific sites on DNA, influencing the topology and transcription; regulates flaA, proU and ompC; is osmoregulated; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (211 aa)
AKN32068.1citrate-ACP transferase, the alpha subunit catalyzes the formation of (3S)-citryl-CoA from acetyl-CoA and citrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (512 aa)
AKN32067.1Citrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HpcH/HpaI aldolase family. (290 aa)
AKN32046.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
AKN31670.11-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
AKN31604.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
AKN31288.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (404 aa)
carACarbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1068 aa)
AKN30963.1Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (318 aa)
AKN30824.15-aminoimidazole-4-carboxamide ribonucleotide transformylase; Catalyzes the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
AKN30572.1acyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
AKN30571.1beta-alanyl-CoA:ammonia lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)
AKN30565.1Phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
AKN30412.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
AKN30345.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
AKN30299.1GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
AKN29985.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)
AKN29650.1Malonate decarboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (565 aa)
AKN29627.1Ribose-phosphate pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
AKN29494.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (478 aa)
AKN29475.1Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (312 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
AKN29431.1Phosphate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
AKN29411.1Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (395 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (209 aa)
udkUridine kinase; Functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
Your Current Organism:
Clostridium carboxidivorans
NCBI taxonomy Id: 536227
Other names: C. carboxidivorans P7, Clostridium carboxidivorans P7, Clostridium carboxidivorans str. P7, Clostridium carboxidivorans strain P7
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