STRINGSTRING
udk udk gpsA gpsA gmk gmk AKN29411.1 AKN29411.1 AKN29421.1 AKN29421.1 coaD coaD AKN29431.1 AKN29431.1 ackA ackA plsX plsX pyrH pyrH AKN29463.1 AKN29463.1 dxr dxr ispG ispG AKN29475.1 AKN29475.1 AKN29484.1 AKN29484.1 AKN29494.1 AKN29494.1 AKN29499.1 AKN29499.1 AKN29500.1 AKN29500.1 AKN29504.1 AKN29504.1 AKN29514.1 AKN29514.1 thiC thiC AKN29548.1 AKN29548.1 add add AKN29553.1 AKN29553.1 AKN29554.1 AKN29554.1 thiG thiG AKN29627.1 AKN29627.1 AKN29628.1 AKN29628.1 AKN29650.1 AKN29650.1 AKN29701.1 AKN29701.1 AKN29745.1 AKN29745.1 AKN29766.1 AKN29766.1 AKN29837.1 AKN29837.1 thiM thiM AKN30126.1 AKN30126.1 AKN30253.1 AKN30253.1 AKN30280.1 AKN30280.1 AKN30299.1 AKN30299.1 AKN30310.1 AKN30310.1 xpt xpt AKN30412.1 AKN30412.1 AKN30565.1 AKN30565.1 AKN30581.1 AKN30581.1 AKN30649.1 AKN30649.1 ispH ispH cmk cmk moaC moaC AKN30735.1 AKN30735.1 AKN30824.1 AKN30824.1 AKN30852.1 AKN30852.1 AKN30939.1 AKN30939.1 AKN31109.1 AKN31109.1 carB carB carA carA plsY plsY AKN31196.1 AKN31196.1 purA purA AKN31233.1 AKN31233.1 dcd dcd AKN31430.1 AKN31430.1 AKN31604.1 AKN31604.1 AKN31670.1 AKN31670.1 AKN31674.1 AKN31674.1 AKN31675.1 AKN31675.1 AKN31679.1 AKN31679.1 mobA mobA AKN31795.1 AKN31795.1 AKN31826.1 AKN31826.1 AKN31882.1 AKN31882.1 AKN31950.1 AKN31950.1 AKN32004.1 AKN32004.1 AKN32005.1 AKN32005.1 AKN32046.1 AKN32046.1 AKN32090.1 AKN32090.1 nadA nadA AKN32116.1 AKN32116.1 AKN32126.1 AKN32126.1 AKN32222.1 AKN32222.1 AKN32263.1 AKN32263.1 nadD nadD coaE coaE AKN32349.1 AKN32349.1 AKN32472.1 AKN32472.1 apt apt AKN32494.1 AKN32494.1 AKN32512.1 AKN32512.1 AKN34209.1 AKN34209.1 AKN32689.1 AKN32689.1 carA-2 carA-2 pyrE pyrE pyrD pyrD pyrK pyrK pyrF pyrF pyrC pyrC AKN32696.1 AKN32696.1 pyrB pyrB guaA guaA guaB guaB AKN32746.1 AKN32746.1 AKN32748.1 AKN32748.1 folD folD AKN32809.1 AKN32809.1 dacA dacA adk adk thyX thyX ispD ispD mcsB mcsB coaX coaX AKN33022.1 AKN33022.1 prs prs glmU glmU accA accA AKN33086.1 AKN33086.1 AKN33087.1 AKN33087.1 fabZ fabZ purA-2 purA-2 psd psd AKN33191.1 AKN33191.1 ispF ispF AKN33263.1 AKN33263.1 ispE ispE pyrG pyrG tdk tdk upp upp atpB atpB atpE atpE AKN33309.1 AKN33309.1 atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC AKN33334.1 AKN33334.1 AKN33350.1 AKN33350.1 AKN33353.1 AKN33353.1 AKN33360.1 AKN33360.1 AKN33363.1 AKN33363.1 deoB deoB folE folE AKN34236.1 AKN34236.1 pdxT pdxT pdxS pdxS nadE nadE araA araA moaA moaA thiM-2 thiM-2 thiE thiE AKN33654.1 AKN33654.1 purE purE purC purC purF purF purM purM purN purN purH purH purD purD AKN33856.1 AKN33856.1 AKN33952.1 AKN33952.1 AKN34031.1 AKN34031.1 dxs dxs nadK nadK AKN34058.1 AKN34058.1 AKN34063.1 AKN34063.1 AKN34073.1 AKN34073.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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udkUridine kinase; Functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (332 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (209 aa)
AKN29411.1Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (395 aa)
AKN29421.1Thiamine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
AKN29431.1Phosphate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
plsXPhosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (336 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa)
AKN29463.1CDP-diglyceride synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDS family. (265 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (384 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (349 aa)
AKN29475.1Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (312 aa)
AKN29484.1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (195 aa)
AKN29494.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (478 aa)
AKN29499.1Molybdenum cofactor biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (84 aa)
AKN29500.1Molybdopterin biosynthesis MoeA protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (302 aa)
AKN29504.1Sulfite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
AKN29514.1Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (154 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (437 aa)
AKN29548.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
addAdenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (341 aa)
AKN29553.1Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
AKN29554.1Thiamine biosynthesis protein ThiF; Catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
AKN29627.1Ribose-phosphate pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
AKN29628.1Nicotinate phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAPRTase family. (489 aa)
AKN29650.1Malonate decarboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (565 aa)
AKN29701.1Thiaminase; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family. (219 aa)
AKN29745.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (176 aa)
AKN29766.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (493 aa)
AKN29837.1Pyridoxamine 5-phosphate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (265 aa)
AKN30126.1NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
AKN30253.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
AKN30280.1Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
AKN30299.1GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
AKN30310.1Pyridoxamine 5'-phosphate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
AKN30412.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
AKN30565.1Phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
AKN30581.1Phosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
AKN30649.1Cytidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1620 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (641 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
moaCMolybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (156 aa)
AKN30735.1Cytoplasmic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
AKN30824.15-aminoimidazole-4-carboxamide ribonucleotide transformylase; Catalyzes the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
AKN30852.1Ribulokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (556 aa)
AKN30939.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
AKN31109.1CDP-alcohol phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (203 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1068 aa)
carACarbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
plsYHypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (197 aa)
AKN31196.1NimC/NimA family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (404 aa)
AKN31233.1Pyridoxamine 5'-phosphate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (175 aa)
AKN31430.1CDP-diacylglycerol--serine O-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (173 aa)
AKN31604.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
AKN31670.11-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
AKN31674.1Molybdopterin biosynthesis protein MoeB; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
AKN31675.1Molybdenum cofactor biosynthesis protein MoaD; Derived by automated computational analysis using gene prediction method: Protein Homology. (74 aa)
AKN31679.1Molybdopterin biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (410 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis protein MobA; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (197 aa)
AKN31795.11-acyl-sn-glycerol-3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (241 aa)
AKN31826.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
AKN31882.1PhnB protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
AKN31950.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
AKN32004.1Molybdopterin-binding protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (340 aa)
AKN32005.1Molybdenum cofactor biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (405 aa)
AKN32046.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
AKN32090.130S ribosomal protein S1; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa)
AKN32116.1Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
AKN32126.1Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (474 aa)
AKN32222.1NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
AKN32263.1Phosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (200 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (211 aa)
AKN32349.1Topology modulation protein; In Listeria monocytogenes this protein binds a specific sites on DNA, influencing the topology and transcription; regulates flaA, proU and ompC; is osmoregulated; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
AKN32472.1(p)ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (724 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
AKN32494.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (173 aa)
AKN32512.1UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
AKN34209.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
AKN32689.1Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1062 aa)
carA-2Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (193 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate. (297 aa)
pyrKDiguanylate cyclase; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (246 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (290 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (394 aa)
AKN32696.1Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
pyrBAspartate carbamoyltransferase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (510 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa)
AKN32746.1NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
AKN32748.1NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
AKN32809.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
dacAMembrane protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (282 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
thyXFAD-dependent thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (246 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (228 aa)
mcsBATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins; Belongs to the ATP:guanido phosphotransferase family. (344 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (259 aa)
AKN33022.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa)
accAacetyl-CoA carboxylase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (281 aa)
AKN33086.1acetyl-CoA carboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AKN33087.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
fabZ3-hydroxyacyl-ACP dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (153 aa)
purA-2Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (295 aa)
AKN33191.1Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa)
AKN33263.11-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
ispE4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (280 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
atpBATP synthase F0F1 subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (227 aa)
atpEATP F0F1 synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa)
AKN33309.1ATP F0F1 synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATPase B chain family. (159 aa)
atpHATP synthase F0F1 subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (179 aa)
atpAATP F0F1 synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (504 aa)
atpGATP synthase F0F1 subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (283 aa)
atpDATP F0F1 synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (466 aa)
atpCATP synthase F0F1 subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (132 aa)
AKN33334.1GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
AKN33350.1CDP-diacylglycerol--serine O-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (173 aa)
AKN33353.1Lipid kinase; Similar to YegS from E. coli; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
AKN33360.1Acyl-phosphate glycerol 3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
AKN33363.1Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. (175 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (393 aa)
folEGTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
AKN34236.1Acyl-phosphate glycerol 3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (238 aa)
pdxTGlutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (192 aa)
pdxSPyridoxal biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (289 aa)
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (637 aa)
araAArabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (488 aa)
moaAMolybdenum cofactor biosynthesis protein MoeA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (318 aa)
thiM-2Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (270 aa)
thiEThiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (204 aa)
AKN33654.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (479 aa)
purMPhosphoribosylaminoimidazole synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (203 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
purDPhosphoribosylamine--glycine ligase; Catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (415 aa)
AKN33856.1CDP-alcohol phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (176 aa)
AKN33952.1ATP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
AKN34031.1Farnesyl-diphosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (293 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa)
nadKInorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (290 aa)
AKN34058.1Metal-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
AKN34063.1Phosphoribosylformylglycinamidine synthase; Catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (1253 aa)
AKN34073.1NAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
Your Current Organism:
Clostridium carboxidivorans
NCBI taxonomy Id: 536227
Other names: C. carboxidivorans P7, Clostridium carboxidivorans P7, Clostridium carboxidivorans str. P7, Clostridium carboxidivorans strain P7
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