(46 nodes) Rossmann-like alpha/beta/alpha sandwich fold network (Clostridium carboxidivorans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AKN33450.1	Restriction endonuclease EcoEI subunit S; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TtcA family. (289 aa)
	AKN33684.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
	AKN33678.1	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
	AKN33677.1	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
	nadE	NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (637 aa)
	argG	Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa)
	AKN33504.1	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
	AKN33503.1	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
	queC	7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (222 aa)
	coaD	Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
	tmcAL	Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (408 aa)
	AKN29475.1	Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (312 aa)
	AKN29575.1	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
	AKN29576.1	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
	glnS	glutamate--tRNA ligase; Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (554 aa)
	AKN29735.1	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
	AKN29736.1	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
	gltX	glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (484 aa)
	AKN30167.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (567 aa)
	AKN30392.1	Potassium ABC transporter ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
	AKN30594.1	Asparagine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa)
	mnmA	Thiouridylase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (358 aa)
	AKN30649.1	Cytidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1620 aa)
	argS	arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (563 aa)
	AKN31244.1	Sulfate adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
	AKN31260.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
	AKN31328.1	valyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (799 aa)
	AKN31435.1	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
	AKN31436.1	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
	tyrS	tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (407 aa)
	AKN31641.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
	cysS	cysteine--tRNA ligase; Catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (471 aa)
	nadD	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (200 aa)
	AKN34205.1	[citrate [pro-3S]-lyase] ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
	valS	valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (882 aa)
	guaA	GMP synthase; Catalyzes the synthesis of GMP from XMP. (510 aa)
	AKN32735.1	Potassium ABC transporter ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TtcA family. (245 aa)
	tyrS-2	tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (406 aa)
	trpS	tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (335 aa)
	AKN32930.1	Citrate lyase ligase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (348 aa)
	cysS-2	cysteinyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (465 aa)
	AKN33023.1	PP-loop domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
	metG	methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (644 aa)
	AKN33234.1	isoleucyl-tRNA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1034 aa)
	AKN33287.1	Queuosine synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
	leuS	leucine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (812 aa)

Your Current Organism:

Clostridium carboxidivorans

NCBI taxonomy Id: 536227
Other names: C. carboxidivorans P7, Clostridium carboxidivorans P7, Clostridium carboxidivorans str. P7, Clostridium carboxidivorans strain P7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKN29475.1	AKN33023.1	Ccar_00915	Ccar_20085	Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family.	PP-loop domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.410
AKN29475.1	coaD	Ccar_00915	Ccar_00670	Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family.	Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.	0.728
AKN29475.1	guaA	Ccar_00915	Ccar_18570	Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.428
AKN29475.1	mnmA	Ccar_00915	Ccar_07090	Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family.	Thiouridylase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.	0.607
AKN29475.1	nadD	Ccar_00915	Ccar_15900	Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family.	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	0.417
AKN29475.1	nadE	Ccar_00915	Ccar_23145	Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family.	NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.553
AKN29575.1	AKN29576.1	Ccar_01425	Ccar_01430	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.989
AKN29575.1	AKN29736.1	Ccar_01425	Ccar_02280	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.972
AKN29575.1	AKN31435.1	Ccar_01425	Ccar_11425	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.969
AKN29575.1	AKN33504.1	Ccar_01425	Ccar_22805	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.975
AKN29575.1	AKN33678.1	Ccar_01425	Ccar_23785	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.978
AKN29576.1	AKN29575.1	Ccar_01430	Ccar_01425	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.989
AKN29576.1	AKN29735.1	Ccar_01430	Ccar_02275	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.970
AKN29576.1	AKN31436.1	Ccar_01430	Ccar_11430	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.961
AKN29576.1	AKN33503.1	Ccar_01430	Ccar_22800	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.975
AKN29576.1	AKN33677.1	Ccar_01430	Ccar_23780	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.976
AKN29735.1	AKN29576.1	Ccar_02275	Ccar_01430	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.970
AKN29735.1	AKN29736.1	Ccar_02275	Ccar_02280	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.985
AKN29735.1	AKN31435.1	Ccar_02275	Ccar_11425	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.964
AKN29735.1	AKN33504.1	Ccar_02275	Ccar_22805	Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.969

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