(30 nodes) 2-Oxocarboxylic acid metabolism network (Thermococcus chitonophagus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	CUX77117.1	Aromatic-amino-acid aminotransferase. (413 aa)
	CUX77207.1	Lysine biosynthesis protein LysX. (274 aa)
	CUX77287.1	Citrate synthase (si). (371 aa)
	CUX77288.1	Isocitrate dehydrogenase [NADP]. (399 aa)
	CUX77289.1	Aconitate hydratase. (827 aa)
	ilvD	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (547 aa)
	CUX77458.1	(R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa)
	CUX77459.1	3-isopropylmalate dehydrogenase. (355 aa)
	leuD	3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)
	leuC	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (423 aa)
	leuA	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). (498 aa)
	ilvC	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa)
	CUX77464.1	Acetolactate synthase large subunit. (562 aa)
	CHITON_0909	Aspartate-semialdehyde dehydrogenase. (334 aa)
	CUX77691.1	Aspartokinase; Belongs to the aspartokinase family. (356 aa)
	CUX77692.1	Aspartokinase. (376 aa)
	CUX77695.1	Acetolactate synthase small subunit. (134 aa)
	CUX78225.1	N-succinyl-L,L-diaminopimelate desuccinylase. (353 aa)
	CUX78372.1	Alanine transaminase. (398 aa)
	CUX78735.1	Biosynthetic Aromatic amino acid aminotransferase alpha. (344 aa)
	lysK	N-acetyl-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. Belongs to the peptidase M20A family. LysK subfamily. (326 aa)
	lysJ	N-acetyl-lysine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (369 aa)
	lysZ	Acetylaminoadipate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (249 aa)
	argC	N-acetyl-gamma-aminoadipyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (330 aa)
	CUX78758.1	Lysine biosynthesis protein LysX. (273 aa)
	CUX78760.1	Homoisocitrate dehydrogenase. (345 aa)
	leuD-2	Homoaconitase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa)
	leuC-2	Homoaconitase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (380 aa)
	CUX78763.1	Homocitrate synthase. (359 aa)
	CUX78764.1	Transcriptional regulator, GntR family domain / Aspartate aminotransferase. (388 aa)

Your Current Organism:

Thermococcus chitonophagus

NCBI taxonomy Id: 54262
Other names: DSM 10152, T. chitonophagus, strain GC74

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHITON_0909	CUX77287.1	CHITON_0909	CHITON_0508	Aspartate-semialdehyde dehydrogenase.	Citrate synthase (si).	0.444
CHITON_0909	CUX77459.1	CHITON_0909	CHITON_0680	Aspartate-semialdehyde dehydrogenase.	3-isopropylmalate dehydrogenase.	0.475
CHITON_0909	CUX77464.1	CHITON_0909	CHITON_0685	Aspartate-semialdehyde dehydrogenase.	Acetolactate synthase large subunit.	0.423
CHITON_0909	CUX77691.1	CHITON_0909	CHITON_0912	Aspartate-semialdehyde dehydrogenase.	Aspartokinase; Belongs to the aspartokinase family.	0.997
CHITON_0909	CUX77692.1	CHITON_0909	CHITON_0913	Aspartate-semialdehyde dehydrogenase.	Aspartokinase.	0.997
CHITON_0909	CUX77695.1	CHITON_0909	CHITON_0916	Aspartate-semialdehyde dehydrogenase.	Acetolactate synthase small subunit.	0.633
CHITON_0909	CUX78760.1	CHITON_0909	CHITON_1981	Aspartate-semialdehyde dehydrogenase.	Homoisocitrate dehydrogenase.	0.475
CHITON_0909	CUX78763.1	CHITON_0909	CHITON_1984	Aspartate-semialdehyde dehydrogenase.	Homocitrate synthase.	0.445
CHITON_0909	argC	CHITON_0909	CHITON_1978	Aspartate-semialdehyde dehydrogenase.	N-acetyl-gamma-aminoadipyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.	0.657
CHITON_0909	ilvC	CHITON_0909	CHITON_0684	Aspartate-semialdehyde dehydrogenase.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.567
CHITON_0909	ilvD	CHITON_0909	CHITON_0678	Aspartate-semialdehyde dehydrogenase.	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.	0.555
CHITON_0909	lysJ	CHITON_0909	CHITON_1976	Aspartate-semialdehyde dehydrogenase.	N-acetyl-lysine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.	0.614
CUX77117.1	CUX77207.1	CHITON_0338	CHITON_0428	Aromatic-amino-acid aminotransferase.	Lysine biosynthesis protein LysX.	0.900
CUX77117.1	CUX78758.1	CHITON_0338	CHITON_1979	Aromatic-amino-acid aminotransferase.	Lysine biosynthesis protein LysX.	0.900
CUX77117.1	CUX78760.1	CHITON_0338	CHITON_1981	Aromatic-amino-acid aminotransferase.	Homoisocitrate dehydrogenase.	0.911
CUX77117.1	CUX78764.1	CHITON_0338	CHITON_1985	Aromatic-amino-acid aminotransferase.	Transcriptional regulator, GntR family domain / Aspartate aminotransferase.	0.903
CUX77207.1	CUX77117.1	CHITON_0428	CHITON_0338	Lysine biosynthesis protein LysX.	Aromatic-amino-acid aminotransferase.	0.900
CUX77207.1	CUX78758.1	CHITON_0428	CHITON_1979	Lysine biosynthesis protein LysX.	Lysine biosynthesis protein LysX.	0.901
CUX77207.1	CUX78764.1	CHITON_0428	CHITON_1985	Lysine biosynthesis protein LysX.	Transcriptional regulator, GntR family domain / Aspartate aminotransferase.	0.900
CUX77207.1	argC	CHITON_0428	CHITON_1978	Lysine biosynthesis protein LysX.	N-acetyl-gamma-aminoadipyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.	0.424