STRINGSTRING
hslV hslV hslU hslU groL groL groS groS cyaY cyaY ACS17863.1 ACS17863.1 ACS18060.1 ACS18060.1 dnaJ dnaJ dnaK dnaK grpE grpE ACS18488.1 ACS18488.1 clpB clpB ACS18490.1 ACS18490.1 ACS18776.1 ACS18776.1 iscS iscS ACS18778.1 ACS18778.1 ACS18779.1 ACS18779.1 hscB hscB hscA hscA ACS18782.1 ACS18782.1 ACS18799.1 ACS18799.1 clpP clpP clpX clpX lon lon clpS clpS ACS19276.1 ACS19276.1 ACS19853.1 ACS19853.1 ACS19854.1 ACS19854.1 ACS19855.1 ACS19855.1 hrcA hrcA erpA erpA ACS21461.1 ACS21461.1 htpG htpG ACS21696.1 ACS21696.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hslV20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (181 aa)
hslUHeat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (442 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (550 aa)
groSChaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
cyaYIron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (110 aa)
ACS17863.1PFAM: peptidase S14 ClpP; KEGG: bpt:Bpet3891 ATP-dependent Clp protease proteolytic component. (198 aa)
ACS18060.1KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. (420 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (378 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (645 aa)
grpEGrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (179 aa)
ACS18488.1PFAM: conserved hypothetical protein; KEGG: rfr:Rfer_3194 hypothetical protein. (330 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (873 aa)
ACS18490.1KEGG: aav:Aave_1250 hypothetical protein. (114 aa)
ACS18776.1Transcriptional regulator, BadM/Rrf2 family; TIGRFAM: iron-sulfur cluster assembly transcription factor IscR; transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074; KEGG: aav:Aave_2442 BadM/Rrf2 family transcriptional regulator. (178 aa)
iscSCysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (406 aa)
ACS18778.1FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (139 aa)
ACS18779.1TIGRFAM: iron-sulfur cluster assembly protein IscA; iron-sulfur cluster assembly accessory protein; PFAM: HesB/YadR/YfhF-family protein; KEGG: pol:Bpro_2180 iron-sulfur cluster assembly protein IscA; Belongs to the HesB/IscA family. (107 aa)
hscBCo-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (172 aa)
hscAFe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. (618 aa)
ACS18782.1TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: dia:Dtpsy_1643 ferredoxin, 2Fe-2S type, ISC system. (112 aa)
ACS18799.1PFAM: 20S proteasome A and B subunits; KEGG: pna:Pnap_1783 20S proteasome, A and B subunits. (197 aa)
clpPATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (202 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (421 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (813 aa)
clpSATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (119 aa)
ACS19276.1KEGG: pol:Bpro_2940 ATPase AAA-2; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. (773 aa)
ACS19853.1PFAM: Phosphoglycerate mutase; KEGG: ara:Arad_14143 mannopine synthesis-like protein. (213 aa)
ACS19854.1PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; KEGG: bav:BAV0873 curved DNA-binding protein. (320 aa)
ACS19855.1KEGG: bav:BAV0874 hypothetical protein. (104 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (336 aa)
erpAIron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters. (121 aa)
ACS21461.1TIGRFAM: thioredoxin; MJ0042 family finger-like protein; PFAM: Thioredoxin domain; KEGG: pna:Pnap_1332 thioredoxin. (149 aa)
htpGHeat shock protein Hsp90; Molecular chaperone. Has ATPase activity. (678 aa)
ACS21696.1TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: dia:Dtpsy_3279 thioredoxin. (306 aa)
Your Current Organism:
Variovorax paradoxus S110
NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110
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