STRINGSTRING
hemF hemF clpS clpS greA greA ACS19233.1 ACS19233.1 ACS19171.1 ACS19171.1 clpX clpX ACS19097.1 ACS19097.1 ACS18942.1 ACS18942.1 ACS18852.1 ACS18852.1 bamD bamD hscA hscA hscB hscB ACS18620.1 ACS18620.1 ACS18619.1 ACS18619.1 ACS18437.1 ACS18437.1 grpE grpE dnaK dnaK dnaJ dnaJ ACS18352.1 ACS18352.1 ACS18183.1 ACS18183.1 asd asd ACS17954.1 ACS17954.1 ACS17780.1 ACS17780.1 groL groL tolB tolB ACS19391.1 ACS19391.1 ACS19512.1 ACS19512.1 ACS19513.1 ACS19513.1 ACS19678.1 ACS19678.1 ACS19836.1 ACS19836.1 ACS19854.1 ACS19854.1 ACS19857.1 ACS19857.1 ACS20050.1 ACS20050.1 ftsB ftsB ACS20068.1 ACS20068.1 ACS20135.1 ACS20135.1 ACS20211.1 ACS20211.1 ACS20370.1 ACS20370.1 argG argG ACS20544.1 ACS20544.1 ACS20607.1 ACS20607.1 secB secB ACS20722.1 ACS20722.1 ACS20740.1 ACS20740.1 ACS20787.1 ACS20787.1 zapD zapD ureE ureE greB greB ACS20951.1 ACS20951.1 ACS21404.1 ACS21404.1 ACS21498.1 ACS21498.1 htpG htpG rpoA rpoA argC argC surA surA ACS22040.1 ACS22040.1 ACS22041.1 ACS22041.1 ACS22043.1 ACS22043.1 ACS22150.1 ACS22150.1 ACS22322.1 ACS22322.1 ACS22377.1 ACS22377.1 ACS22582.1 ACS22582.1 ACS22602.1 ACS22602.1 ACS22648.1 ACS22648.1 ACS22764.1 ACS22764.1 ACS22817.1 ACS22817.1 ACS22833.1 ACS22833.1 ACS16858.1 ACS16858.1 ACS16947.1 ACS16947.1 ACS17724.1 ACS17724.1 ACS17013.1 ACS17013.1 ACS17043.1 ACS17043.1 ACS17211.1 ACS17211.1 ACS17345.1 ACS17345.1 ACS17556.1 ACS17556.1 ACS17591.1 ACS17591.1 minE minE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hemFCoproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (305 aa)
clpSATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (119 aa)
greATranscription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (158 aa)
ACS19233.1PFAM: outer membrane chaperone Skp (OmpH); KEGG: vei:Veis_1447 outer membrane chaperone Skp (OmpH); Belongs to the skp family. (180 aa)
ACS19171.1Protein of unknown function DUF710; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (110 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (421 aa)
ACS19097.1PFAM: Terminase; KEGG: net:Neut_1472 phage terminase. (550 aa)
ACS18942.1Phosphate uptake regulator, PhoU; Plays a role in the regulation of phosphate uptake. (233 aa)
ACS18852.1PFAM: protein of unknown function DUF924; KEGG: bbr:BB2250 hypothetical protein. (183 aa)
bamDOuter membrane assembly lipoprotein YfiO; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (268 aa)
hscAFe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. (618 aa)
hscBCo-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (172 aa)
ACS18620.1PFAM: heat shock protein Hsp20; KEGG: lch:Lcho_3375 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (145 aa)
ACS18619.1PFAM: heat shock protein Hsp20; KEGG: lch:Lcho_3376 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (139 aa)
ACS18437.1PFAM: alpha/beta hydrolase fold; KEGG: pna:Pnap_1631 alpha/beta hydrolase fold. (304 aa)
grpEGrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (179 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (645 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (378 aa)
ACS18352.1PFAM: alpha/beta hydrolase fold; KEGG: bra:BRADO0881 alpha/beta family hydrolase. (307 aa)
ACS18183.1PFAM: histidine kinase dimerisation and phosphoacceptor region; KEGG: afw:Anae109_3354 histidine kinase. (563 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (380 aa)
ACS17954.1PFAM: alpha/beta hydrolase fold; KEGG: pol:Bpro_3711 alpha/beta hydrolase fold. (299 aa)
ACS17780.1PFAM: alpha/beta hydrolase fold; KEGG: rfr:Rfer_3189 alpha/beta hydrolase. (303 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (550 aa)
tolBTol-Pal system beta propeller repeat protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (408 aa)
ACS19391.1PFAM: alpha/beta hydrolase fold; KEGG: bph:Bphy_6462 alpha/beta hydrolase fold protein. (305 aa)
ACS19512.1PFAM: protein of unknown function DUF330; KEGG: mms:mma_1055 hypothetical protein. (210 aa)
ACS19513.1PFAM: Mammalian cell entry related domain protein; KEGG: mms:mma_1054 paraquat-inducible protein B. (548 aa)
ACS19678.1Histidine kinase; KEGG: mpt:Mpe_A3044 methanol utilization control sensor protein MoxY, putative; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; histidine kinase HAMP region domain protein; SMART: histidine kinase HAMP region domain protein; ATP-binding region ATPase domain protein. (459 aa)
ACS19836.1PFAM: alpha/beta hydrolase fold; KEGG: bpt:Bpet1576 hypothetical protein. (290 aa)
ACS19854.1PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; KEGG: bav:BAV0873 curved DNA-binding protein. (320 aa)
ACS19857.1PFAM: OmpA/MotB domain protein; KEGG: azo:azo0281 hypothetical protein. (218 aa)
ACS20050.1PFAM: NlpBDapX family lipoprotein; KEGG: rfr:Rfer_2096 NlpBDapX lipoprotein. (364 aa)
ftsBSeptum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (92 aa)
ACS20068.1Hsp33 protein; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. (335 aa)
ACS20135.1PFAM: heat shock protein Hsp20; KEGG: pol:Bpro_3264 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (123 aa)
ACS20211.1Histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; KEGG: rme:Rmet_0613 periplasmic sensor signal transduction histidine kinase. (626 aa)
ACS20370.1KEGG: dac:Daci_2123 putative lipoprotein. (194 aa)
argGKEGG: pol:Bpro_1599 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (446 aa)
ACS20544.1PFAM: alpha/beta hydrolase fold; KEGG: bpa:BPP1032 putative hydrolase. (303 aa)
ACS20607.1Histidine kinase; KEGG: aav:Aave_4230 integral membrane sensor signal transduction histidine kinase; PFAM: Cache type 2 domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein. (456 aa)
secBProtein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (154 aa)
ACS20722.1Histidine kinase; KEGG: pol:Bpro_0880 multi-sensor signal transduction histidine kinase; PFAM: CHASE3 domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein. (439 aa)
ACS20740.1KEGG: aav:Aave_3642 hypothetical protein. (190 aa)
ACS20787.1Flagellar basal body-associated protein FliL; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (165 aa)
zapDProtein of unknown function DUF1342; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (251 aa)
ureEUreE urease accessory domain protein; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family. (193 aa)
greBTranscription elongation factor GreB; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. (190 aa)
ACS20951.1KEGG: pol:Bpro_1298 hypothetical protein. (655 aa)
ACS21404.1Hypothetical protein; KEGG: dia:Dtpsy_0552 poly(hydroxyalkanoate) granule-associated protein. (177 aa)
ACS21498.1KEGG: pna:Pnap_2741 hypothetical protein. (155 aa)
htpGHeat shock protein Hsp90; Molecular chaperone. Has ATPase activity. (678 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (307 aa)
surASurA domain protein; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (469 aa)
ACS22040.1PFAM: alpha/beta hydrolase fold; KEGG: bbt:BBta_7159 alpha/beta family hydrolase. (356 aa)
ACS22041.1PFAM: alpha/beta hydrolase fold; KEGG: smd:Smed_3910 alpha/beta hydrolase fold. (341 aa)
ACS22043.1PFAM: Calcium/calmodulin dependent protein kinase II association-domain protein; KEGG: rso:RS03100 putative signal peptide protein. (143 aa)
ACS22150.1KEGG: afw:Anae109_1809 histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein. (620 aa)
ACS22322.1PFAM: alpha/beta hydrolase fold; KEGG: mlo:mlr2710 hydrolase. (288 aa)
ACS22377.1PFAM: alpha/beta hydrolase fold; KEGG: rpe:RPE_4492 alpha/beta hydrolase fold. (321 aa)
ACS22582.1PFAM: transcription elongation factor GreA/GreB domain protein; KEGG: aav:Aave_4026 GreA/GreB family elongation factor. (133 aa)
ACS22602.1Histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; KEGG: pna:Pnap_4085 integral membrane sensor signal transduction histidine kinase. (659 aa)
ACS22648.1PFAM: alpha/beta hydrolase fold; KEGG: rfr:Rfer_0307 alpha/beta hydrolase. (278 aa)
ACS22764.1PFAM: alpha/beta hydrolase fold; KEGG: scl:sce7520 putative hydrolase. (297 aa)
ACS22817.1PFAM: alpha/beta hydrolase fold; KEGG: bpy:Bphyt_4957 alpha/beta hydrolase fold. (277 aa)
ACS22833.1PFAM: alpha/beta hydrolase fold; KEGG: sme:SM_b20216 putative epoxide hydrolase protein. (340 aa)
ACS16858.1PFAM: protein of unknown function DUF796; KEGG: bpa:BPP0716 hypothetical protein. (160 aa)
ACS16947.1Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. (326 aa)
ACS17724.1TIGRFAM: general secretion pathway protein D; PFAM: type II and III secretion system protein; NolW domain protein; KEGG: ajs:Ajs_0667 general secretion pathway protein D. (774 aa)
ACS17013.1TIGRFAM: poly(hydroxyalkanoate) granule-associated protein; PFAM: poly granule associated family protein; KEGG: pol:Bpro_4024 poly granule associated. (167 aa)
ACS17043.1Histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; KEGG: rso:RSc3160 two component sensor histidine kinase transcription regulator protein. (657 aa)
ACS17211.1PFAM: protein of unknown function DUF796; KEGG: lch:Lcho_4089 hypothetical protein. (160 aa)
ACS17345.1PFAM: MscS Mechanosensitive ion channel; KEGG: vei:Veis_0172 MscS mechanosensitive ion channel. (362 aa)
ACS17556.1PFAM: protein of unknown function DUF945; KEGG: dac:Daci_4282 hypothetical protein. (505 aa)
ACS17591.1Putative signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; KEGG: rfr:Rfer_3372 putative signal transduction histidine kinase. (614 aa)
minECell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (92 aa)
Your Current Organism:
Variovorax paradoxus S110
NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110
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