32 items (Variovorax paradoxus S110) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dnaK	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (645 aa)
	ACS20678.1	PFAM: cytoplasmic chaperone TorD family protein; KEGG: pol:Bpro_0935 cytoplasmic chaperone TorD. (205 aa)
	ACS20646.1	PFAM: peptidylprolyl isomerase FKBP-type; KEGG: aav:Aave_3772 peptidylprolyl isomerase, FKBP-type. (147 aa)
	ACS20068.1	Hsp33 protein; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. (335 aa)
	ACS20055.1	KEGG: dia:Dtpsy_0919 fkbp-type peptidyl-prolyl cis-trans isomerase. (174 aa)
	ACS19892.1	PFAM: peptidylprolyl isomerase FKBP-type; KEGG: dia:Dtpsy_1738 peptidylprolyl isomerase. (142 aa)
	ACS19854.1	PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; KEGG: bav:BAV0873 curved DNA-binding protein. (320 aa)
	ACS19712.1	Peptidyl-prolyl cis-trans isomerase cyclophilin type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (170 aa)
	ACS19711.1	Peptidyl-prolyl cis-trans isomerase cyclophilin type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (199 aa)
	dsbB	Disulphide bond formation protein DsbB; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. (171 aa)
	ACS19233.1	PFAM: outer membrane chaperone Skp (OmpH); KEGG: vei:Veis_1447 outer membrane chaperone Skp (OmpH); Belongs to the skp family. (180 aa)
	clpX	ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (421 aa)
	tig	Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (437 aa)
	hscA	Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. (618 aa)
	hscB	Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (172 aa)
	ACS18569.1	KEGG: pcr:Pcryo_1830 P pilus assembly protein chaperone PapD-like. (242 aa)
	clpB	ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (873 aa)
	ACS18364.1	PFAM: peptidylprolyl isomerase FKBP-type; KEGG: aav:Aave_1387 peptidylprolyl isomerase. (116 aa)
	grpE	GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (179 aa)
	dnaJ	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (378 aa)
	ACS18060.1	KEGG: dac:Daci_1060 molecular chaperone, HSP70 class. (420 aa)
	groS	Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
	groL	Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (550 aa)
	ACS17193.1	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. (909 aa)
	ACS16863.1	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. (908 aa)
	secB	Protein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (154 aa)
	ACS20776.1	KEGG: bac:BamMC406_2972 hypothetical protein. (92 aa)
	ureE	UreE urease accessory domain protein; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family. (193 aa)
	ACS21249.1	Thiol:disulfide interchange protein DsbC; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily. (240 aa)
	htpG	Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. (678 aa)
	ACS21848.1	KEGG: pol:Bpro_4719 peptidylprolyl isomerase, FKBP-type. (158 aa)
	surA	SurA domain protein; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (469 aa)

Your Current Organism:

Variovorax paradoxus S110

NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACS16863.1	ACS17193.1	Vapar_0200	Vapar_0530	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	0.902
ACS16863.1	ACS18060.1	Vapar_0200	Vapar_1409	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	KEGG: dac:Daci_1060 molecular chaperone, HSP70 class.	0.862
ACS16863.1	ACS19854.1	Vapar_0200	Vapar_3236	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; KEGG: bav:BAV0873 curved DNA-binding protein.	0.744
ACS16863.1	dnaJ	Vapar_0200	Vapar_1711	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.742
ACS16863.1	dnaK	Vapar_0200	Vapar_1712	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.890
ACS16863.1	groL	Vapar_0200	Vapar_1118	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.706
ACS16863.1	groS	Vapar_0200	Vapar_1119	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.706
ACS16863.1	grpE	Vapar_0200	Vapar_1713	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.869
ACS16863.1	hscA	Vapar_0200	Vapar_2146	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	0.866
ACS16863.1	htpG	Vapar_0200	Vapar_4976	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity.	0.775
ACS17193.1	ACS16863.1	Vapar_0530	Vapar_0200	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Type VI secretion ATPase, ClpV1 family; KEGG: bpt:Bpet4107 putative ATPase with chaperone activity; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	0.902
ACS17193.1	ACS18060.1	Vapar_0530	Vapar_1409	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	KEGG: dac:Daci_1060 molecular chaperone, HSP70 class.	0.862
ACS17193.1	ACS19854.1	Vapar_0530	Vapar_3236	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; KEGG: bav:BAV0873 curved DNA-binding protein.	0.744
ACS17193.1	dnaJ	Vapar_0530	Vapar_1711	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.742
ACS17193.1	dnaK	Vapar_0530	Vapar_1712	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.876
ACS17193.1	groL	Vapar_0530	Vapar_1118	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.703
ACS17193.1	groS	Vapar_0530	Vapar_1119	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.706
ACS17193.1	grpE	Vapar_0530	Vapar_1713	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.869
ACS17193.1	hscA	Vapar_0530	Vapar_2146	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	0.866
ACS17193.1	htpG	Vapar_0530	Vapar_4976	Type VI secretion ATPase, ClpV1 family; KEGG: azo:azo3903 putative ATP-dependent Clp protease, ATP-binding subunit ClpB; TIGRFAM: type VI secretion ATPase, ClpV1 family; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.	Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity.	0.775