STRINGSTRING
clpX clpX ACS22890.1 ACS22890.1 clpP clpP ACS18971.1 ACS18971.1 ACS18382.1 ACS18382.1 dnaK dnaK dnaJ dnaJ groS groS ACS17694.1 ACS17694.1 ACS16973.1 ACS16973.1 ACS16753.1 ACS16753.1 panD panD ACS22834.1 ACS22834.1 panD-2 panD-2 ACS22548.1 ACS22548.1 ACS22470.1 ACS22470.1 ACS22280.1 ACS22280.1 htpG htpG lexA lexA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (421 aa)
ACS22890.1PFAM: Aldehyde Dehydrogenase; KEGG: pca:Pcar_1074 putative aldehyde dehydrogenase. (460 aa)
clpPATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (202 aa)
ACS18971.1PFAM: Aldehyde Dehydrogenase; KEGG: pol:Bpro_2290 aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (477 aa)
ACS18382.1PFAM: Aldehyde Dehydrogenase; KEGG: pna:Pnap_1598 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (645 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (378 aa)
groSChaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
ACS17694.1PFAM: Aldehyde Dehydrogenase; KEGG: aav:Aave_2256 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
ACS16973.1PFAM: Aldehyde Dehydrogenase; KEGG: rfr:Rfer_0880 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
ACS16753.1PFAM: Aldehyde Dehydrogenase; KEGG: lch:Lcho_3656 aldehyde dehydrogenase. (516 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (133 aa)
ACS22834.1PFAM: Aldehyde Dehydrogenase; KEGG: pfo:Pfl01_2261 aldehyde dehydrogenase. (476 aa)
panD-2Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (133 aa)
ACS22548.1PFAM: Aldehyde Dehydrogenase; KEGG: reu:Reut_A1842 betaine-aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (475 aa)
ACS22470.1PFAM: Aldehyde Dehydrogenase; acyl-CoA reductase; KEGG: swi:Swit_1605 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (481 aa)
ACS22280.1PFAM: Aldehyde Dehydrogenase; KEGG: pna:Pnap_3013 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (506 aa)
htpGHeat shock protein Hsp90; Molecular chaperone. Has ATPase activity. (678 aa)
lexASOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (227 aa)
Your Current Organism:
Variovorax paradoxus S110
NCBI taxonomy Id: 543728
Other names: V. paradoxus S110, Variovorax paradoxus str. S110, Variovorax paradoxus strain S110
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