(122 nodes) Signal transduction, and Protein dephosphorylation network (Histoplasma capsulatum H88)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCEG_00530	Uncharacterized protein. (280 aa)
	HCEG_01381	Uncharacterized protein. (317 aa)
	HCEG_01398	Ras guanine-nucleotide exchange protein Cdc25p. (1182 aa)
	HCEG_00627	LIM domain-containing protein. (818 aa)
	HCEG_01436	Predicted protein. (251 aa)
	HCEG_01515	Rho1 GTPase. (192 aa)
	HCEG_01606	cAMP-dependent protein kinase regulatory subunit. (448 aa)
	HCEG_01628	GTPase-activating protein. (785 aa)
	HCEG_00022	Protein kinase domain-containing protein. (275 aa)
	HCEG_00099	Rho GTPase activator. (1247 aa)
	HCEG_01788	GTPase-activating protein. (1278 aa)
	HCEG_00115	Phosphoinositide phospholipase C. (661 aa)
	HCEG_00124	Protein-tyrosine phosphatase. (497 aa)
	HCEG_00996	Uncharacterized protein. (230 aa)
	HCEG_01814	Uncharacterized protein. (474 aa)
	HCEG_01839	Predicted protein. (338 aa)
	HCEG_00203	Uncharacterized protein. (267 aa)
	HCEG_01009	Uncharacterized protein. (160 aa)
	HCEG_01092	Small GTPase. (192 aa)
	HCEG_00299	Uncharacterized protein. (198 aa)
	HCEG_01117	Uncharacterized protein. (327 aa)
	HCEG_01238	Uncharacterized protein. (239 aa)
	HCEG_00437	Serine/threonine protein kinase ppk6. (1139 aa)
	HCEG_00458	Predicted protein. (132 aa)
	HCEG_01298	Uncharacterized protein. (779 aa)
	HCEG_01977	Predicted protein. (173 aa)
	HCEG_02038	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (326 aa)
	HCEG_02085	GTPase Ras2p. (362 aa)
	HCEG_02104	ZZ type zinc finger domain-containing protein. (846 aa)
	HCEG_02907	3-phosphoinositide-dependent protein kinase. (836 aa)
	HCEG_02971	Serine/threonine protein kinase Sgk2. (230 aa)
	HCEG_02223	U-box domain-containing protein. (759 aa)
	HCEG_03084	Uncharacterized protein. (332 aa)
	HCEG_03109	Protein kinase domain-containing protein. (383 aa)
	HCEG_02274	Uncharacterized protein. (201 aa)
	HCEG_02276	Uncharacterized protein. (131 aa)
	HCEG_03117	Cell division control protein. (1164 aa)
	HCEG_03219	Rho GTPase activator. (738 aa)
	HCEG_02379	Rho guanyl nucleotide exchange factor. (963 aa)
	HCEG_02491	Uncharacterized protein. (381 aa)
	HCEG_02596	Uncharacterized protein. (402 aa)
	HCEG_02676	ELMO/CED-12 family protein. (720 aa)
	HCEG_01910	Uncharacterized protein. (725 aa)
	HCEG_03739	Small G-beta protein GPB. (353 aa)
	HCEG_04540	U-box domain-containing protein. (284 aa)
	HCEG_04572	Serine/threonine protein kinase. (317 aa)
	HCEG_03749	PH domain-containing protein. (393 aa)
	HCEG_03773	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1126 aa)
	HCEG_03865	Protein phosphatase; Belongs to the PP2C family. (437 aa)
	HCEG_03254	FYVE domain-containing protein. (286 aa)
	HCEG_04074	AT DNA binding protein. (323 aa)
	HCEG_03386	Protein phosphatase 2C. (675 aa)
	HCEG_04236	Serine/threonine protein kinase. (338 aa)
	HCEG_04265	Rheb small monomeric GTPase RhbA. (187 aa)
	HCEG_03525	cAMP-specific phosphodiesterase. (544 aa)
	HCEG_03534	Protein kinase domain-containing protein. (391 aa)
	HCEG_03541	Endoglucanase. (343 aa)
	HCEG_03606	Protein phosphatase 2C. (629 aa)
	HCEG_04456	Uncharacterized protein. (823 aa)
	HCEG_03641	Uncharacterized protein. (717 aa)
	HCEG_04506	Serine/threonine protein kinase. (311 aa)
	HCEG_04616	MARVEL domain-containing protein. (147 aa)
	HCEG_05461	Phosphodiesterase. (971 aa)
	HCEG_05491	Leucine rich repeat domain-containing protein. (806 aa)
	HCEG_05523	Sin3p binding protein. (856 aa)
	HCEG_05558	Rap guanine nucleotide exchange factor 5. (979 aa)
	HCEG_04736	Uncharacterized protein. (318 aa)
	HCEG_04737	Protein tyrosine phosphatase. (342 aa)
	HCEG_04766	Predicted protein. (188 aa)
	HCEG_04773	Leucine rich repeat domain-containing protein. (1035 aa)
	HCEG_05655	Alternative oxidase. (357 aa)
	HCEG_05689	Adenylate cyclase. (781 aa)
	HCEG_05690	Adenylate cyclase. (1046 aa)
	HCEG_04962	SH3 domain-containing protein. (224 aa)
	HCEG_04979	Protein kinase. (416 aa)
	HCEG_04981	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (343 aa)
	HCEG_05838	Protein kinase. (593 aa)
	HCEG_05089	Uncharacterized protein. (280 aa)
	HCEG_05185	DNA damage checkpoint protein rad24; Belongs to the 14-3-3 family. (268 aa)
	HCEG_05310	G_PROTEIN_RECEP_F2_4 domain-containing protein. (484 aa)
	HCEG_05346	Predicted protein. (306 aa)
	HCEG_04609	Lysophospholipase NTE1; Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. (1584 aa)
	HCEG_06365	Uncharacterized protein. (175 aa)
	HCEG_06410	RAS small monomeric GTPase. (247 aa)
	HCEG_07284	Von Willebrand RING finger domain-containing protein. (1057 aa)
	HCEG_06476	cAMP-dependent protein kinase; Belongs to the protein kinase superfamily. (412 aa)
	HCEG_06478	Rho1 GDP-GTP exchange protein. (1224 aa)
	HCEG_07312	Chitin synthase. (297 aa)
	HCEG_07329	Uncharacterized protein. (654 aa)
	HCEG_06511	Small G-protein GPA1. (353 aa)
	HCEG_06542	Chimerin. (1205 aa)
	HCEG_06545	Mannosylphosphate transferase. (259 aa)
	HCEG_06643	Rho GDP dissociation inhibitor. (205 aa)
	HCEG_06670	Uncharacterized protein. (212 aa)
	HCEG_05988	Protein kinase. (396 aa)
	HCEG_06829	TRAF-type zinc finger protein. (474 aa)
	HCEG_06877	Protein kinase domain-containing protein. (335 aa)
	HCEG_06882	Rho3 GTPase. (281 aa)
	HCEG_06113	PH domain-containing protein. (983 aa)
	HCEG_06227	Serine/threonine protein kinase. (1323 aa)
	HCEG_07052	Rho GTPase activator. (664 aa)
	HCEG_07058	Rac1 GTPase. (199 aa)
	HCEG_07124	Uncharacterized protein. (207 aa)
	HCEG_06328	Uncharacterized protein. (250 aa)
	HCEG_07145	Ubiquitin-conjugating enzyme E2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	HCEG_07471	Uncharacterized protein. (276 aa)
	HCEG_07481	Integrase_H2C2 domain-containing protein. (417 aa)
	HCEG_07562	Cytokinesis protein SepA/Bni1. (1741 aa)
	HCEG_07833	Protein kinase. (605 aa)
	HCEG_08204	Small G-protein GPA3. (356 aa)
	HCEG_08316	Leupaxin. (570 aa)
	HCEG_08362	MAP kinase. (405 aa)
	HCEG_08460	Non-specific serine/threonine protein kinase. (872 aa)
	HCEG_08462	Protein kinase domain-containing protein. (336 aa)
	HCEG_08651	cAMP-dependent protein kinase. (559 aa)
	HCEG_08669	Protein kinase domain-containing protein. (200 aa)
	HCEG_08892	Hydrophobin 1. (99 aa)
	HCEG_08907	SH3 and Ded_cyto domain-containing protein; Belongs to the DOCK family. (2202 aa)
	HCEG_08956	Deubiquitination-protection protein dph1. (473 aa)
	HCEG_08968	DH domain-containing protein. (819 aa)
	HCEG_09178	Guanine nucleotide-binding protein alpha-2 subunit. (340 aa)
	HCEG_09308	RhoGAP domain-containing protein. (1748 aa)

Your Current Organism:

Histoplasma capsulatum H88

NCBI taxonomy Id: 544711
Other names: Ajellomyces capsulatus H88, H. capsulatum H88

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCEG_00022	HCEG_00099	F0U6M1	F0U755	Protein kinase domain-containing protein.	Rho GTPase activator.	0.481
HCEG_00022	HCEG_00124	F0U6M1	F0U7I5	Protein kinase domain-containing protein.	Protein-tyrosine phosphatase.	0.530
HCEG_00022	HCEG_00299	F0U6M1	F0U8N2	Protein kinase domain-containing protein.	Uncharacterized protein.	0.448
HCEG_00022	HCEG_00458	F0U6M1	F0U9J9	Protein kinase domain-containing protein.	Predicted protein.	0.466
HCEG_00022	HCEG_00627	F0U6M1	F0U564	Protein kinase domain-containing protein.	LIM domain-containing protein.	0.456
HCEG_00022	HCEG_00996	F0U6M1	F0U7R5	Protein kinase domain-containing protein.	Uncharacterized protein.	0.511
HCEG_00022	HCEG_01009	F0U6M1	F0U834	Protein kinase domain-containing protein.	Uncharacterized protein.	0.458
HCEG_00022	HCEG_01092	F0U6M1	F0U8I0	Protein kinase domain-containing protein.	Small GTPase.	0.448
HCEG_00022	HCEG_01238	F0U6M1	F0U9D4	Protein kinase domain-containing protein.	Uncharacterized protein.	0.448
HCEG_00022	HCEG_01398	F0U6M1	F0U4Z3	Protein kinase domain-containing protein.	Ras guanine-nucleotide exchange protein Cdc25p.	0.417
HCEG_00022	HCEG_01436	F0U6M1	F0U583	Protein kinase domain-containing protein.	Predicted protein.	0.448
HCEG_00022	HCEG_01515	F0U6M1	F0U5L6	Protein kinase domain-containing protein.	Rho1 GTPase.	0.448
HCEG_00022	HCEG_01628	F0U6M1	F0U683	Protein kinase domain-containing protein.	GTPase-activating protein.	0.418
HCEG_00022	HCEG_01788	F0U6M1	F0U7F9	Protein kinase domain-containing protein.	GTPase-activating protein.	0.436
HCEG_00022	HCEG_01814	F0U6M1	F0U7U0	Protein kinase domain-containing protein.	Uncharacterized protein.	0.528
HCEG_00022	HCEG_01910	F0U6M1	F0UDF4	Protein kinase domain-containing protein.	Uncharacterized protein.	0.671
HCEG_00022	HCEG_02038	F0U6M1	F0UA51	Protein kinase domain-containing protein.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.614
HCEG_00022	HCEG_02085	F0U6M1	F0UAF1	Protein kinase domain-containing protein.	GTPase Ras2p.	0.448
HCEG_00022	HCEG_02104	F0U6M1	F0UAH0	Protein kinase domain-containing protein.	ZZ type zinc finger domain-containing protein.	0.751
HCEG_00022	HCEG_02274	F0U6M1	F0UBK3	Protein kinase domain-containing protein.	Uncharacterized protein.	0.530