104 items (Histoplasma capsulatum H88) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCEG_01500	SAP domain-containing protein. (421 aa)
	HCEG_00694	DNA repair protein RAD1. (401 aa)
	HCEG_00695	Predicted protein. (77 aa)
	HCEG_00708	Glucose-repressible alcohol dehydrogenase. (769 aa)
	HCEG_01630	Exosome complex exonuclease RRP6. (807 aa)
	HCEG_01679	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2232 aa)
	HCEG_00019	DNA cross-link repair protein pso2/snm1. (841 aa)
	HCEG_00022	Protein kinase domain-containing protein. (275 aa)
	HCEG_00038	Exonuclease. (782 aa)
	HCEG_01718	Uncharacterized protein. (236 aa)
	HCEG_00133	Eukaryotic translation initiation factor 2c. (902 aa)
	HCEG_00170	Oligoribonuclease. (189 aa)
	HCEG_00291	Uncharacterized protein. (458 aa)
	HCEG_01128	Endonuclease. (333 aa)
	HCEG_01982	Zn(2)-C6 fungal-type domain-containing protein. (661 aa)
	HCEG_02863	Uncharacterized protein. (704 aa)
	HCEG_02865	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (1042 aa)
	HCEG_02916	Crossover junction endonuclease mus81. (650 aa)
	HCEG_02983	Ribonuclease T2-like protein; Belongs to the RNase T2 family. (433 aa)
	HCEG_03011	CAF1 family ribonuclease. (522 aa)
	HCEG_03025	Endonuclease/exonuclease/phosphatase. (299 aa)
	HCEG_03026	Curved DNA-binding protein. (414 aa)
	HCEG_03053	DNA polymerase. (1111 aa)
	HCEG_03103	Histidine triad nucleotide-binding protein. (281 aa)
	HCEG_02297	DNA replication helicase Dna2. (1609 aa)
	HCEG_02298	Uncharacterized protein. (337 aa)
	HCEG_03165	Uncharacterized protein. (101 aa)
	HCEG_03196	3'-5' exonuclease/helicase. (935 aa)
	HCEG_03204	Uncharacterized protein. (257 aa)
	HCEG_03241	Calcium/calmodulin dependent protein kinase. (163 aa)
	HCEG_02583	Cell wall biogenesis protein phosphatase Ssd1. (1382 aa)
	HCEG_01894	Bifunctional P-450:NADPH-P450 reductase; Belongs to the cytochrome P450 family. (457 aa)
	HCEG_02758	Uncharacterized protein. (827 aa)
	HCEG_03734	XPG I-region protein. (729 aa)
	HCEG_04557	Tyrosyl-DNA phosphodiesterase. (682 aa)
	HCEG_03797	ATP-dependent helicase DCL1. (1432 aa)
	HCEG_03874	RNA-3'-phosphate cyclase. (402 aa)
	HCEG_03886	Ribonuclease P protein subunit p30. (316 aa)
	USB1	U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (330 aa)
	HCEG_03999	CCR4-NOT transcription complex. (511 aa)
	HCEG_03285	Endoribonuclease ysh1. (893 aa)
	HCEG_03319	Ribonuclease Z. (1123 aa)
	HCEG_04182	3'-5' exonuclease. (536 aa)
	HCEG_04201	Exonuclease. (830 aa)
	HCEG_03655	Uncharacterized protein. (427 aa)
	HCEG_03680	DNA polymerase gamma. (1146 aa)
	HCEG_04672	Piwi domain-containing protein. (168 aa)
	HCEG_04708	XPG_I_2 domain-containing protein. (728 aa)
	HCEG_04709	PINc domain-containing protein. (196 aa)
	HCEG_05535	DNA repair protein. (705 aa)
	HCEG_05885	Dicer-like protein; Belongs to the helicase family. Dicer subfamily. (1436 aa)
	HCEG_05903	Uncharacterized protein. (183 aa)
	HCEG_05087	Mitochondrial exoribonuclease Cyt-4. (1007 aa)
	HCEG_05108	Uncharacterized protein. (234 aa)
	SLX4	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (843 aa)
	HCEG_05316	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (820 aa)
	HCEG_05437	TNase-like domain-containing protein. (315 aa)
	HCEG_06377	RNA-binding protein. (884 aa)
	HCEG_07318	RNase H domain-containing protein. (429 aa)
	HCEG_06538	60S ribosomal protein. (394 aa)
	HCEG_07366	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (341 aa)
	HCEG_07367	Peroxin 16. (1143 aa)
	HCEG_06686	tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (310 aa)
	HCEG_06774	RNA exonuclease. (324 aa)
	HCEG_05980	Double-strand break repair protein; Belongs to the MRE11/RAD32 family. (1016 aa)
	HCEG_06054	ERCC4 domain-containing protein. (627 aa)
	HCEG_06060	Uncharacterized protein. (273 aa)
	HCEG_06072	RNA lariat debranching enzyme. (752 aa)
	HCEG_06210	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1451 aa)
	HCEG_07035	Predicted protein. (266 aa)
	HCEG_07040	Endo/exonuclease/phosphatase domain-containing protein. (636 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (421 aa)
	HCEG_06286	Uncharacterized protein. (557 aa)
	HCEG_06334	20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (430 aa)
	HCEG_06336	tRNA-splicing endonuclease subunit SEN2. (497 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (359 aa)
	HCEG_07486	RNase3 domain-containing protein. (380 aa)
	HCEG_12010	Laglidadg endonuclease. (361 aa)
	HCEG_12009	Laglidadg endonuclease. (324 aa)
	HCEG_12002	Laglidadg endonuclease. (276 aa)
	HCEG_09244	tRNA splicing endonuclease subunit. (503 aa)
	HCEG_09230	Uncharacterized protein. (95 aa)
	HCEG_09203	UV-damage endonuclease. (704 aa)
	HCEG_09189	RNA exonuclease. (638 aa)
	HCEG_09102	RNAse P Rpr2/Rpp21 subunit domain-containing protein. (200 aa)
	HCEG_08818	Uncharacterized protein. (238 aa)
	HCEG_08742	F-box domain-containing protein. (416 aa)
	HCEG_08618	Uncharacterized protein. (1589 aa)
	HCEG_08570	Endonuclease/exonuclease/phosphatase. (330 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1190 aa)
	HCEG_08441	Smr domain-containing protein. (557 aa)
	HCEG_08434	DNA excision repair protein Rad2. (1159 aa)
	HCEG_08404	Serine/threonine protein kinase. (1157 aa)
	HCEG_08325	DNA repair protein RAD1. (975 aa)
	HCEG_08282	Ribonuclease P complex subunit Pop1. (987 aa)
	HCEG_08071	Uncharacterized protein. (88 aa)
	HCEG_07874	Translin-associated protein. (282 aa)
	HCEG_07586	Tyrosyl-DNA phosphodiesterase domain-containing protein. (652 aa)
	HCEG_07528	HLA class III protein Dom3z. (334 aa)
	HCEG_01365	Mating-type switching protein swi10. (361 aa)
	HCEG_00559	Piwi domain-containing protein. (1038 aa)
	HCEG_01423	Predicted protein. (205 aa)
	HCEG_00626	Mitotic control protein dis3; Belongs to the RNR ribonuclease family. (1037 aa)
	HCEG_01470	Hydrolase. (299 aa)

Your Current Organism:

Histoplasma capsulatum H88

NCBI taxonomy Id: 544711
Other names: Ajellomyces capsulatus H88, H. capsulatum H88

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	HCEG_00019	F0UQE4	F0U6L8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA cross-link repair protein pso2/snm1.	0.499
FEN1	HCEG_00291	F0UQE4	F0U8M4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.561
FEN1	HCEG_00694	F0UQE4	F0U5N7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA repair protein RAD1.	0.878
FEN1	HCEG_00695	F0UQE4	F0U5N8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Predicted protein.	0.878
FEN1	HCEG_01128	F0UQE4	F0U8R9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Endonuclease.	0.631
FEN1	HCEG_01365	F0UQE4	F0U4Q6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Mating-type switching protein swi10.	0.839
FEN1	HCEG_01500	F0UQE4	F0U5K1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	SAP domain-containing protein.	0.449
FEN1	HCEG_01679	F0UQE4	F0U6I9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.954
FEN1	HCEG_01894	F0UQE4	F0UD84	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Bifunctional P-450:NADPH-P450 reductase; Belongs to the cytochrome P450 family.	0.753
FEN1	HCEG_02297	F0UQE4	F0UBM6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication helicase Dna2.	0.975
FEN1	HCEG_02758	F0UQE4	F0UDL2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.699
FEN1	HCEG_02916	F0UQE4	F0UAJ2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Crossover junction endonuclease mus81.	0.898
FEN1	HCEG_03053	F0UQE4	F0UB84	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.996
FEN1	HCEG_03103	F0UQE4	F0UBI7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Histidine triad nucleotide-binding protein.	0.510
FEN1	HCEG_03196	F0UQE4	F0UC35	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	3'-5' exonuclease/helicase.	0.999
FEN1	HCEG_03680	F0UQE4	F0UHB8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase gamma.	0.609
FEN1	HCEG_04201	F0UQE4	F0UFN4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Exonuclease.	0.906
FEN1	HCEG_04557	F0UQE4	F0UDY1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Tyrosyl-DNA phosphodiesterase.	0.616
FEN1	HCEG_05903	F0UQE4	F0UK53	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.463
FEN1	HCEG_05980	F0UQE4	F0UNF0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Double-strand break repair protein; Belongs to the MRE11/RAD32 family.	0.991