(98 nodes) Organelle localization network (Histoplasma capsulatum H88)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCEG_06641	APSES transcription factor. (437 aa)
	HCEG_02942	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (193 aa)
	HCEG_02948	Microtubule associated protein EB1. (250 aa)
	HCEG_02980	Vacuolar assembly protein. (1283 aa)
	HCEG_02179	GTP-binding protein. (547 aa)
	HCEG_02209	ATP-binding cassette sub-family E member 1. (615 aa)
	HCEG_02241	HMG box domain-containing protein. (321 aa)
	HCEG_03080	Syntaxin. (359 aa)
	HCEG_03218	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (230 aa)
	HCEG_02432	C2 domain-containing protein. (1237 aa)
	HCEG_02672	Dynamin family protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (801 aa)
	HCEG_02770	Uncharacterized protein. (508 aa)
	HCEG_03796	Dynein heavy chain. (4361 aa)
	HCEG_03876	CAP-Gly domain-containing protein. (698 aa)
	HCEG_04024	ATP-binding cassette sub-family F member 2. (627 aa)
	HCEG_04068	Anucleate primary sterigmata protein A. (1582 aa)
	TIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (258 aa)
	HCEG_04133	Sec8 exocyst complex component specific domain-containing protein. (1183 aa)
	HCEG_03379	Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (516 aa)
	HCEG_04225	Meiotically up-regulated gene 185 protein. (616 aa)
	HCEG_03456	Golgi membrane protein. (766 aa)
	HCEG_03547	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (753 aa)
	HCEG_03606	Protein phosphatase 2C. (629 aa)
	HCEG_03619	Probable vacuolar protein sorting-associated protein 16 homolog; Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. (830 aa)
	MDM10	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...] (467 aa)
	HCEG_03636	Armadillo repeat protein. (580 aa)
	HCEG_04631	Zuotin. (445 aa)
	HCEG_05467	N-acetyltransferase. (190 aa)
	HCEG_05497	Calmodulin-binding protein Sha1. (1108 aa)
	HCEG_05509	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. (72 aa)
	HCEG_05563	Small G-protein Gsp1p. (331 aa)
	HCEG_05653	Uncharacterized protein. (532 aa)
	HCEG_05905	Vacuolar morphogenesis protein AvaB. (1071 aa)
	HCEG_05119	Transmembrane protein. (1509 aa)
	HCEG_05958	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (801 aa)
	HCEG_05207	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (999 aa)
	HCEG_05335	MIND kinetochore complex component Nnf1. (238 aa)
	HCEG_07248	SNARE domain-containing protein; Belongs to the syntaxin family. (377 aa)
	HCEG_06529	Exocyst complex component SEC5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (1033 aa)
	HCEG_06532	Spindle pole body component. (887 aa)
	HCEG_07365	Cupin domain-containing protein. (617 aa)
	HCEG_06629	Uncharacterized protein. (797 aa)
	CLU1	Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. (1273 aa)
	HCEG_06755	Sec1 family superfamily; Belongs to the STXBP/unc-18/SEC1 family. (670 aa)
	HCEG_09160	Prohibitin. (280 aa)
	HCEG_09086	Uncharacterized protein. (344 aa)
	HCEG_09027	Protein transport protein sec16; Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy; Belongs to the SEC16 family. (1768 aa)
	HCEG_08970	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (213 aa)
	HCEG_08849	P150 dynactin NUDM. (1362 aa)
	HCEG_08830	Uncharacterized protein. (135 aa)
	HCEG_08447	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (641 aa)
	HCEG_08233	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
	PAC1	Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family. (456 aa)
	HCEG_08115	Low temperature viability protein ltv1. (464 aa)
	HCEG_08113	Large subunit GTPase. (680 aa)
	HCEG_08103	Vacuolar sorting-associated protein. (973 aa)
	HCEG_08022	Ribosome biogenesis ATPase RIX7. (751 aa)
	HCEG_07996	Intermediate filament protein. (1260 aa)
	HCEG_07962	Exportin. (1069 aa)
	HCEG_07815	Chromosome segregation protein. (571 aa)
	HCEG_07682	Uncharacterized protein. (837 aa)
	HCEG_07653	GTPase-activating protein. (487 aa)
	HCEG_07491	Exocyst complex component SEC15; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (747 aa)
	HCEG_07397	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
	HCEG_07107	Uncharacterized protein. (380 aa)
	HCEG_06994	Vacuolar segregation protein PEP7. (672 aa)
	HCEG_06173	SNARE domain-containing protein. (239 aa)
	HCEG_06059	E3 ubiquitin-protein ligase PEP5. (948 aa)
	HCEG_06032	SUN domain-containing protein. (729 aa)
	HCEG_06828	SNARE domain-containing protein. (415 aa)
	HCEG_06773	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (441 aa)
	HCEG_09331	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1030 aa)
	HCEG_09312	Bud site selection protein. (284 aa)
	HCEG_09304	Mitochondrial distribution and morphology protein. (750 aa)
	HCEG_09267	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (188 aa)
	HCEG_09194	Tyrosine-protein phosphatase CDC14. (411 aa)
	HCEG_00499	DUF2263 domain-containing protein. (331 aa)
	HCEG_00518	Nuclear movement protein. (198 aa)
	HCEG_00596	Serine/threonine protein kinase plo1. (1177 aa)
	HCEG_01450	MSP domain-containing protein. (295 aa)
	HCEG_01473	SNARE domain-containing protein; Belongs to the syntaxin family. (270 aa)
	HCEG_00787	Centractin; Belongs to the actin family. (381 aa)
	HCEG_00810	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (565 aa)
	HCEG_00034	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	HCEG_00854	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (666 aa)
	HCEG_00902	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (476 aa)
	HCEG_01755	SNARE domain-containing protein. (363 aa)
	HCEG_01825	C2H2 finger domain-containing protein. (115 aa)
	HCEG_01848	DASH complex component Dam1. (202 aa)
	HCEG_01028	Uncharacterized protein. (292 aa)
	HCEG_00279	HEC/Ndc80p family protein. (734 aa)
	HCEG_00307	Uncharacterized protein. (337 aa)
	HCEG_01134	Nuclear distribution protein NudE. (584 aa)
	HCEG_01147	Uncharacterized protein. (919 aa)
	HCEG_01971	Chromosome segregation protein. (1587 aa)
	HCEG_02866	Uncharacterized protein. (931 aa)
	HCEG_02071	Serine/threonine protein kinase. (501 aa)
	HCEG_02920	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (847 aa)

Your Current Organism:

Histoplasma capsulatum H88

NCBI taxonomy Id: 544711
Other names: Ajellomyces capsulatus H88, H. capsulatum H88

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCEG_00034	HCEG_00279	F0U6N3	F0U8L2	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	HEC/Ndc80p family protein.	0.502
HCEG_00034	HCEG_00596	F0U6N3	F0U533	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Serine/threonine protein kinase plo1.	0.806
HCEG_00034	HCEG_00787	F0U6N3	F0U634	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Centractin; Belongs to the actin family.	0.864
HCEG_00034	HCEG_01971	F0U6N3	F0U9T4	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Chromosome segregation protein.	0.469
HCEG_00034	HCEG_02920	F0U6N3	F0UAJ6	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.543
HCEG_00034	HCEG_02948	F0U6N3	F0UAM4	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Microtubule associated protein EB1.	0.922
HCEG_00034	HCEG_03606	F0U6N3	F0UGZ2	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Protein phosphatase 2C.	0.424
HCEG_00034	HCEG_03796	F0U6N3	F0UE51	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Dynein heavy chain.	0.982
HCEG_00034	HCEG_03876	F0U6N3	F0UED1	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	CAP-Gly domain-containing protein.	0.757
HCEG_00034	HCEG_04068	F0U6N3	F0UEZ6	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Anucleate primary sterigmata protein A.	0.469
HCEG_00034	HCEG_05207	F0U6N3	F0UKN8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.803
HCEG_00034	HCEG_05509	F0U6N3	F0UHT5	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	0.517
HCEG_00034	HCEG_05958	F0U6N3	F0UKG2	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.650
HCEG_00034	HCEG_06629	F0U6N3	F0UMU7	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Uncharacterized protein.	0.655
HCEG_00034	HCEG_06755	F0U6N3	F0UN73	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Sec1 family superfamily; Belongs to the STXBP/unc-18/SEC1 family.	0.666
HCEG_00034	HCEG_07397	F0U6N3	F0UQK5	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.919
HCEG_00034	HCEG_08022	F0U6N3	F0USD0	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Ribosome biogenesis ATPase RIX7.	0.505
HCEG_00034	HCEG_08233	F0U6N3	F0USZ1	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.712
HCEG_00034	HCEG_08447	F0U6N3	F0UTK5	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.687
HCEG_00034	HCEG_09160	F0U6N3	F0UVL8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Prohibitin.	0.527