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HCEG_00490 HCEG_00490 HCEG_00578 HCEG_00578 HCEG_01474 HCEG_01474 HCEG_01475 HCEG_01475 HCEG_00660 HCEG_00660 MDE1 MDE1 HCEG_01536 HCEG_01536 HCEG_01556 HCEG_01556 HCEG_00843 HCEG_00843 NTH1 NTH1 HCEG_00986 HCEG_00986 HCEG_01823 HCEG_01823 HCEG_00188 HCEG_00188 HCEG_01170 HCEG_01170 HCEG_01258 HCEG_01258 HCEG_02864 HCEG_02864 HCEG_02962 HCEG_02962 cyn1 cyn1 HCEG_02322 HCEG_02322 HCEG_02408 HCEG_02408 HCEG_02509 HCEG_02509 HCEG_02545 HCEG_02545 HCEG_02601 HCEG_02601 HCEG_01934 HCEG_01934 HCEG_03705 HCEG_03705 HCEG_03819 HCEG_03819 HCEG_03828 HCEG_03828 HCEG_04086 HCEG_04086 PSD1 PSD1 HCEG_04459 HCEG_04459 HCEG_04641 HCEG_04641 HCEG_05477 HCEG_05477 HCEG_04756 HCEG_04756 HCEG_04761 HCEG_04761 HCEG_05666 HCEG_05666 HCEG_05737 HCEG_05737 HCEG_05744 HCEG_05744 HCEG_04941 HCEG_04941 HCEG_05301 HCEG_05301 HCEG_07219 HCEG_07219 HCEG_07303 HCEG_07303 HCEG_06517 HCEG_06517 HCEG_06686 HCEG_06686 HCEG_06848 HCEG_06848 PSD2 PSD2 HCEG_07553 HCEG_07553 HCEG_07817 HCEG_07817 HCEG_07945 HCEG_07945 HCEG_07958 HCEG_07958 HCEG_08430 HCEG_08430 HCEG_08439 HCEG_08439 HCEG_08455 HCEG_08455 HCEG_08731 HCEG_08731 HCEG_08802 HCEG_08802 HCEG_08935 HCEG_08935 HCEG_09065 HCEG_09065 HCEG_09127 HCEG_09127 HCEG_09232 HCEG_09232
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HCEG_00490Threonine dehydratase. (562 aa)
HCEG_00578Isocitrate lyase. (537 aa)
HCEG_01474Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (307 aa)
HCEG_01475Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (406 aa)
HCEG_00660Sphingosine-1-phosphate lyase. (573 aa)
MDE1Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (240 aa)
HCEG_01536Chorismate synthase. (407 aa)
HCEG_01556Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (868 aa)
HCEG_008433-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (773 aa)
NTH1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (533 aa)
HCEG_00986Dihydrodipicolinate synthetase; Belongs to the DapA family. (313 aa)
HCEG_01823Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (778 aa)
HCEG_00188Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (360 aa)
HCEG_01170Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (287 aa)
HCEG_01258Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (534 aa)
HCEG_028643-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family. (1574 aa)
HCEG_02962Glutamate decarboxylase. (566 aa)
cyn1Cyanate hydratase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family. (163 aa)
HCEG_02322Formamidopyrimidine-DNA glycosylase lyase mutM. (383 aa)
HCEG_02408Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (228 aa)
HCEG_02509Dihydrodipicolinate synthetase; Belongs to the DapA family. (331 aa)
HCEG_02545Urea hydro-lyase/cyanamide hydratase. (254 aa)
HCEG_02601HpcH/HpaI aldolase/citrate lyase family protein. (270 aa)
HCEG_01934Argininosuccinate lyase. (471 aa)
HCEG_03705Uracil-5-carboxylate decarboxylase; Belongs to the metallo-dependent hydrolases superfamily. (285 aa)
HCEG_03819ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (386 aa)
HCEG_03828Cystathionine gamma-lyase. (425 aa)
HCEG_04086Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (427 aa)
PSD1Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily. (546 aa)
HCEG_04459Glutamate decarboxylase; Belongs to the group II decarboxylase family. (516 aa)
HCEG_04641Aromatic-L-amino acid decarboxylase. (539 aa)
HCEG_05477Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (323 aa)
HCEG_04756Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (338 aa)
HCEG_04761Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (192 aa)
HCEG_05666Pyridoxal-dependent decarboxylase. (444 aa)
HCEG_05737Hydroxymethylglutaryl-CoA lyase. (355 aa)
HCEG_05744Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (575 aa)
HCEG_04941Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (227 aa)
HCEG_05301Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (222 aa)
HCEG_07219Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (243 aa)
HCEG_07303Lactoylglutathione lyase; Belongs to the GST superfamily. (264 aa)
HCEG_06517Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities. (770 aa)
HCEG_06686tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (310 aa)
HCEG_06848Pyruvate formate lyase activating enzyme. (239 aa)
PSD2Phosphatidylserine decarboxylase 2 alpha chain; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily. (1063 aa)
HCEG_07553Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (797 aa)
HCEG_07817Cystathionine beta-lyase MetG. (447 aa)
HCEG_07945Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family. (549 aa)
HCEG_07958Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (378 aa)
HCEG_08430Citrate lyase subunit beta-like protein. (321 aa)
HCEG_08439Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (479 aa)
HCEG_08455Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (309 aa)
HCEG_08731DNA lyase. (528 aa)
HCEG_08802Tryptophan synthase. (723 aa)
HCEG_089353,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (235 aa)
HCEG_09065Isocitrate lyase. (600 aa)
HCEG_09127Glutamate decarboxylase; Belongs to the group II decarboxylase family. (569 aa)
HCEG_09232ATP-citrate lyase. (486 aa)
Your Current Organism:
Histoplasma capsulatum H88
NCBI taxonomy Id: 544711
Other names: Ajellomyces capsulatus H88, H. capsulatum H88
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