60 items (Histoplasma capsulatum H88) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCEG_02315	Ubiquitin-conjugating enzyme. (139 aa)
	HCEG_01354	BZIP domain-containing protein. (252 aa)
	HCEG_01357	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (367 aa)
	HCEG_01359	Fungal specific transcription factor domain-containing protein. (760 aa)
	HCEG_01525	Uncharacterized protein. (126 aa)
	HCEG_01570	CBS domain-containing protein; Involved in DNA replication and cell separation. Belongs to the SDS23 family. (540 aa)
	HCEG_00760	Uncharacterized protein. (114 aa)
	HCEG_00790	C-x8-C-x5-C-x3-H zinc finger protein. (582 aa)
	HCEG_01603	ESCRT-III component. (223 aa)
	HCEG_01607	Uncharacterized protein. (377 aa)
	HCEG_00824	Serine/threonine protein kinase. (1019 aa)
	HCEG_01789	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (966 aa)
	HCEG_00196	ATG11 domain-containing protein. (1303 aa)
	HCEG_00401	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (1089 aa)
	HCEG_02016	Protein kinase. (987 aa)
	HCEG_02104	ZZ type zinc finger domain-containing protein. (846 aa)
	HCEG_02985	Ubiquitin-like domain-containing protein. (152 aa)
	HCEG_03039	SNF7 family protein. (495 aa)
	HCEG_02253	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (272 aa)
	HCEG_03195	Uncharacterized protein. (132 aa)
	HCEG_02439	Cell division control protein. (266 aa)
	HCEG_02569	Non-specific serine/threonine protein kinase. (955 aa)
	HCEG_04558	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. (333 aa)
	HCEG_03752	ATG16 domain-containing protein. (208 aa)
	HCEG_03887	Casein kinase II; Belongs to the protein kinase superfamily. (328 aa)
	HCEG_03922	Uncharacterized protein. (550 aa)
	HCEG_04227	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. (508 aa)
	HCEG_04405	Non-specific serine/threonine protein kinase. (837 aa)
	HCEG_03600	UV radiation resistance protein. (550 aa)
	HCEG_03608	SNF7 family protein. (217 aa)
	HCEG_03609	Transmembrane GTPase fzo1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (937 aa)
	HCEG_03617	Ubiquitin C-terminal hydrolase; Belongs to the peptidase C19 family. (734 aa)
	HCEG_04433	S import receptor. (631 aa)
	HCEG_03677	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2803 aa)
	HCEG_05685	DJ-1/PfpI family protein. (227 aa)
	HCEG_07196	Mitochondrial import receptor subunit tom22. (159 aa)
	MDM34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (618 aa)
	HCEG_06453	Phosphatidylinositol 3-kinase VPS34. (912 aa)
	HCEG_06481	SVP1-like protein. (370 aa)
	HCEG_06483	Dynein light intermediate chain. (543 aa)
	HCEG_07347	Autophagy-related protein. (118 aa)
	HCEG_06609	Vacuolar targeting protein Atg18. (438 aa)
	HCEG_05983	Mitochondrial import receptor subunit tom-20. (175 aa)
	HCEG_05997	Vacuolar sorting-associated protein. (227 aa)
	HCEG_06903	Uncharacterized protein. (1626 aa)
	HCEG_06225	ThiJ/PfpI family protein. (245 aa)
	HCEG_07522	Mitochondrial import receptor subunit TOM40. (352 aa)
	HCEG_07602	Snf1 kinase complex beta-subunit Gal83. (552 aa)
	HCEG_07947	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (702 aa)
	HCEG_08023	SNF7 family protein. (211 aa)
	HCEG_08140	DUF1649 domain-containing protein. (245 aa)
	HCEG_08149	Autophagy-related protein 3. (378 aa)
	HCEG_08255	Ubiquitin-conjugating enzyme E2; Belongs to the ubiquitin-conjugating enzyme family. (156 aa)
	HCEG_08454	Uncharacterized protein. (362 aa)
	HCEG_08548	Uncharacterized protein. (179 aa)
	HCEG_08634	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily. (665 aa)
	HCEG_08635	Uncharacterized protein. (86 aa)
	HCEG_08664	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. (179 aa)
	HCEG_08931	Magnesium dependent phosphatase. (222 aa)
	HCEG_09293	Autophagy_act_C domain-containing protein. (265 aa)

Your Current Organism:

Histoplasma capsulatum H88

NCBI taxonomy Id: 544711
Other names: Ajellomyces capsulatus H88, H. capsulatum H88

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCEG_00196	HCEG_00760	F0U812	F0U607	ATG11 domain-containing protein.	Uncharacterized protein.	0.506
HCEG_00196	HCEG_00824	F0U812	F0U6C6	ATG11 domain-containing protein.	Serine/threonine protein kinase.	0.986
HCEG_00196	HCEG_01354	F0U812	F0U4P5	ATG11 domain-containing protein.	BZIP domain-containing protein.	0.506
HCEG_00196	HCEG_01603	F0U812	F0U658	ATG11 domain-containing protein.	ESCRT-III component.	0.531
HCEG_00196	HCEG_01789	F0U812	F0U7G0	ATG11 domain-containing protein.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.987
HCEG_00196	HCEG_02016	F0U812	F0UA29	ATG11 domain-containing protein.	Protein kinase.	0.575
HCEG_00196	HCEG_02569	F0U812	F0UCS8	ATG11 domain-containing protein.	Non-specific serine/threonine protein kinase.	0.528
HCEG_00196	HCEG_02985	F0U812	F0UAW3	ATG11 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.506
HCEG_00196	HCEG_03039	F0U812	F0UB70	ATG11 domain-containing protein.	SNF7 family protein.	0.440
HCEG_00196	HCEG_03922	F0U812	F0UEH7	ATG11 domain-containing protein.	Uncharacterized protein.	0.765
HCEG_00196	HCEG_04227	F0U812	F0UFW3	ATG11 domain-containing protein.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy.	0.510
HCEG_00196	HCEG_04405	F0U812	F0UGV1	ATG11 domain-containing protein.	Non-specific serine/threonine protein kinase.	0.544
HCEG_00196	HCEG_04558	F0U812	F0UDY2	ATG11 domain-containing protein.	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.	0.511
HCEG_00196	HCEG_06453	F0U812	F0UM41	ATG11 domain-containing protein.	Phosphatidylinositol 3-kinase VPS34.	0.715
HCEG_00196	HCEG_06609	F0U812	F0UMS7	ATG11 domain-containing protein.	Vacuolar targeting protein Atg18.	0.520
HCEG_00196	HCEG_06903	F0U812	F0UNY4	ATG11 domain-containing protein.	Uncharacterized protein.	0.679
HCEG_00196	HCEG_07347	F0U812	F0UME0	ATG11 domain-containing protein.	Autophagy-related protein.	0.546
HCEG_00196	HCEG_07947	F0U812	F0US55	ATG11 domain-containing protein.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...]	0.655
HCEG_00196	HCEG_08140	F0U812	F0USP8	ATG11 domain-containing protein.	DUF1649 domain-containing protein.	0.948
HCEG_00196	HCEG_08149	F0U812	F0USQ7	ATG11 domain-containing protein.	Autophagy-related protein 3.	0.511