STRINGSTRING
HCEG_04725 HCEG_04725 HCEG_05316 HCEG_05316 HCEG_06780 HCEG_06780 SLX1 SLX1 HCEG_07953 HCEG_07953 HCEG_00325 HCEG_00325 HCEG_02985 HCEG_02985 HCEG_01354 HCEG_01354 HCEG_00019 HCEG_00019
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HCEG_04725Phosphatidyl inositol 3-kinase; Belongs to the PI3/PI4-kinase family. (2474 aa)
HCEG_05316Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (820 aa)
HCEG_06780Asparaginyl-tRNA synthetase. (581 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (421 aa)
HCEG_07953Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (602 aa)
HCEG_00325Nuclear transport factor 2. (131 aa)
HCEG_02985Ubiquitin-like domain-containing protein. (152 aa)
HCEG_01354BZIP domain-containing protein. (252 aa)
HCEG_00019DNA cross-link repair protein pso2/snm1. (841 aa)
Your Current Organism:
Histoplasma capsulatum H88
NCBI taxonomy Id: 544711
Other names: Ajellomyces capsulatus H88, H. capsulatum H88
Server load: low (18%) [HD]