63 items (Histoplasma capsulatum H88) - STRING interaction network

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second shell of interactors

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Predicted Interactions

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	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (359 aa)
	HCEG_01864	Predicted protein. (184 aa)
	HCEG_01896	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (272 aa)
	HCEG_03862	Uncharacterized protein. (84 aa)
	HCEG_04203	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (343 aa)
	HCEG_04204	Predicted protein. (332 aa)
	HCEG_04257	Uncharacterized protein. (108 aa)
	HCEG_04258	Uncharacterized protein. (165 aa)
	HCEG_04300	RING-1 protein. (121 aa)
	HCEG_03572	Telomere length regulator protein. (1231 aa)
	HCEG_03645	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (667 aa)
	HCEG_03672	SsDNA binding protein Ssb3. (117 aa)
	HCEG_04520	DNA polymerase. (1458 aa)
	HCEG_05498	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (914 aa)
	HCEG_05571	DNA polymerase epsilon subunit B. (747 aa)
	HCEG_04789	DNA polymerase delta small subunit. (565 aa)
	HCEG_05620	DNA helicase; Belongs to the MCM family. (1806 aa)
	HCEG_04910	Activator 1 41 kDa subunit. (394 aa)
	HCEG_05761	Activator 1 subunit 5. (352 aa)
	HCEG_05767	Replication factor C subunit 1. (1071 aa)
	HCEG_04965	Cyclin-dependent protein kinase; Belongs to the protein kinase superfamily. (315 aa)
	HCEG_05108	Uncharacterized protein. (234 aa)
	HCEG_05334	Cyclin-dependent protein kinase; Belongs to the protein kinase superfamily. (400 aa)
	HCEG_06721	DNA helicase; Belongs to the MCM family. (965 aa)
	HCEG_06739	CBFD_NFYB_HMF domain-containing protein. (199 aa)
	HCEG_06064	Chromo domain-containing protein. (345 aa)
	HCEG_06067	Uncharacterized protein. (404 aa)
	HCEG_06955	DNA helicase; Belongs to the MCM family. (882 aa)
	HCEG_06134	DNA helicase; Belongs to the MCM family. (718 aa)
	HCEG_06226	Uncharacterized protein. (194 aa)
	HCEG_02582	Ubiquitin-conjugating enzyme E2; Belongs to the ubiquitin-conjugating enzyme family. (543 aa)
	HCEG_07540	Activator 1 37 kDa subunit. (354 aa)
	HCEG_07912	G1 cyclin; Belongs to the cyclin family. (419 aa)
	HCEG_07934	Nucleolar protein NOP2. (1473 aa)
	HCEG_07953	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (602 aa)
	HCEG_08445	Telomere silencing protein Zds1. (803 aa)
	HCEG_08744	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (284 aa)
	HCEG_08870	DNA helicase; Belongs to the MCM family. (877 aa)
	HCEG_08973	Uncharacterized protein. (522 aa)
	HCEG_09236	DNA polymerase delta subunit 4. (214 aa)
	HCEG_09238	Uncharacterized protein. (470 aa)
	HCEG_09266	Activator 1 subunit 3. (443 aa)
	HCEG_01354	BZIP domain-containing protein. (252 aa)
	HCEG_01423	Predicted protein. (205 aa)
	HCEG_00762	TPR domain-containing protein. (433 aa)
	HCEG_01679	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2232 aa)
	HCEG_01097	DNA ligase. (945 aa)
	HCEG_02023	Uncharacterized protein. (138 aa)
	HCEG_02910	UDP-galactopyranose mutase. (533 aa)
	HCEG_02152	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
	HCEG_02964	DNA ligase. (844 aa)
	HCEG_02985	Ubiquitin-like domain-containing protein. (152 aa)
	HCEG_02180	CBFD_NFYB_HMF domain-containing protein. (310 aa)
	HCEG_03053	DNA polymerase. (1111 aa)
	HCEG_03105	G2/mitotic-specific cyclin cdc13; Belongs to the cyclin family. (646 aa)
	HCEG_02297	DNA replication helicase Dna2. (1609 aa)
	HCEG_02303	G2/mitotic-specific cyclin-B; Belongs to the cyclin family. (501 aa)
	HCEG_02352	Uncharacterized protein. (605 aa)
	HCEG_02358	DNA replication complex GINS protein psf3. (177 aa)
	HCEG_02359	Uncharacterized protein. (932 aa)
	HCEG_03181	Cell division cycle protein. (763 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (818 aa)
	HCEG_02479	PSF1 domain-containing protein. (277 aa)

Your Current Organism:

Histoplasma capsulatum H88

NCBI taxonomy Id: 544711
Other names: Ajellomyces capsulatus H88, H. capsulatum H88

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	HCEG_01097	F0UQE4	F0U8I5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.976
FEN1	HCEG_01354	F0UQE4	F0U4P5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	BZIP domain-containing protein.	0.402
FEN1	HCEG_01679	F0UQE4	F0U6I9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.954
FEN1	HCEG_01896	F0UQE4	F0UD86	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.606
FEN1	HCEG_02152	F0UQE4	F0UAS1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.541
FEN1	HCEG_02180	F0UQE4	F0UB02	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	CBFD_NFYB_HMF domain-containing protein.	0.878
FEN1	HCEG_02297	F0UQE4	F0UBM6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication helicase Dna2.	0.975
FEN1	HCEG_02964	F0UQE4	F0UAU2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.973
FEN1	HCEG_02985	F0UQE4	F0UAW3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ubiquitin-like domain-containing protein.	0.402
FEN1	HCEG_03053	F0UQE4	F0UB84	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.996
FEN1	HCEG_03181	F0UQE4	F0UC20	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Cell division cycle protein.	0.680
FEN1	HCEG_03572	F0UQE4	F0UGQ7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Telomere length regulator protein.	0.927
FEN1	HCEG_03645	F0UQE4	F0UH83	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.916
FEN1	HCEG_04203	F0UQE4	F0UFN6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.878
FEN1	HCEG_04204	F0UQE4	F0UFN7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Predicted protein.	0.878
FEN1	HCEG_04300	F0UQE4	F0UG90	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	RING-1 protein.	0.532
FEN1	HCEG_04520	F0UQE4	F0UHH1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.886
FEN1	HCEG_04789	F0UQE4	F0UIG9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase delta small subunit.	0.987
FEN1	HCEG_04910	F0UQE4	F0UJ46	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Activator 1 41 kDa subunit.	0.973
FEN1	HCEG_04965	F0UQE4	F0UJF4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Cyclin-dependent protein kinase; Belongs to the protein kinase superfamily.	0.499