47 items (Histoplasma capsulatum H88) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCEG_06497	Osmosensor protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. (325 aa)
	HCEG_07250	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (253 aa)
	HCEG_06349	UBA/TS-N domain-containing protein. (885 aa)
	SLX4	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (843 aa)
	HCEG_05179	Polarized growth protein. (1017 aa)
	HCEG_05147	Golgi to endosome transporter. (541 aa)
	HCEG_04992	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (712 aa)
	HCEG_04817	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1676 aa)
	HCEG_04113	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (468 aa)
	HCEG_04054	COP9 signalosome complex subunit. (396 aa)
	HCEG_03847	COP9 signalosome complex subunit 8. (221 aa)
	HCEG_02776	Uncharacterized protein; Belongs to the ClpA/ClpB family. (925 aa)
	HCEG_02554	Uncharacterized protein. (772 aa)
	HCEG_03184	RhoGAP and Fes/CIP4 domain-containing protein. (875 aa)
	HCEG_02217	MFS amine transporter. (477 aa)
	HCEG_02985	Ubiquitin-like domain-containing protein. (152 aa)
	HCEG_02073	DDE_Tnp_1_7 domain-containing protein. (180 aa)
	HCEG_02875	Fes/CIP4 homology domain-containing protein. (909 aa)
	HCEG_02838	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa)
	HCEG_01979	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (937 aa)
	HCEG_01284	COP9 signalosome complex subunit 3. (498 aa)
	HCEG_00387	Vacuolar sorting receptor. (313 aa)
	HCEG_01207	Ubiquitin-like domain-containing protein. (78 aa)
	HCEG_00356	Serine/threonine protein kinase ppk30. (1014 aa)
	HCEG_00334	LMBR1 domain-containing protein. (865 aa)
	HCEG_00333	BAG domain-containing protein. (492 aa)
	HCEG_00286	SH3 domain-containing protein. (866 aa)
	HCEG_00973	Actin polymerization protein Bzz1. (734 aa)
	HCEG_00698	COP9 signalosome complex subunit. (339 aa)
	HCEG_01354	BZIP domain-containing protein. (252 aa)
	HCEG_08917	EH domain binding protein epsin. (548 aa)
	HCEG_08956	Deubiquitination-protection protein dph1. (473 aa)
	HCEG_09081	Synaptobrevin. (118 aa)
	HCEG_08320	Actin associated protein Wsp1. (670 aa)
	HCEG_08198	Cytoskeletal adaptor protein SagA. (405 aa)
	HCEG_08196	Uncharacterized protein. (754 aa)
	HCEG_07923	ENTH domain-containing protein. (677 aa)
	HCEG_07753	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (708 aa)
	HCEG_07398	EF hand domain-containing protein. (1279 aa)
	HCEG_07160	Phosphatidylinositol-4-phosphate 5-kinase its3. (956 aa)
	HCEG_08629	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (755 aa)
	HCEG_07126	COP9 signalosome complex subunit. (508 aa)
	HCEG_07034	Cytoskeleton assembly control protein. (1051 aa)
	HCEG_05990	Uncharacterized protein; Belongs to the synaptobrevin family. (248 aa)
	HCEG_06746	Uncharacterized protein. (301 aa)
	HCEG_06653	DUF1681 domain-containing protein. (352 aa)
	HCEG_06597	Uncharacterized protein. (324 aa)

Your Current Organism:

Histoplasma capsulatum H88

NCBI taxonomy Id: 544711
Other names: Ajellomyces capsulatus H88, H. capsulatum H88

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCEG_00286	HCEG_00356	F0U8L9	F0U8Z2	SH3 domain-containing protein.	Serine/threonine protein kinase ppk30.	0.716
HCEG_00286	HCEG_00973	F0U8L9	F0U7P2	SH3 domain-containing protein.	Actin polymerization protein Bzz1.	0.847
HCEG_00286	HCEG_01207	F0U8L9	F0U951	SH3 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.591
HCEG_00286	HCEG_01354	F0U8L9	F0U4P5	SH3 domain-containing protein.	BZIP domain-containing protein.	0.591
HCEG_00286	HCEG_01979	F0U8L9	F0U9U2	SH3 domain-containing protein.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.673
HCEG_00286	HCEG_02838	F0U8L9	F0UA10	SH3 domain-containing protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.970
HCEG_00286	HCEG_02875	F0U8L9	F0UA98	SH3 domain-containing protein.	Fes/CIP4 homology domain-containing protein.	0.557
HCEG_00286	HCEG_02985	F0U8L9	F0UAW3	SH3 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.591
HCEG_00286	HCEG_03184	F0U8L9	F0UC23	SH3 domain-containing protein.	RhoGAP and Fes/CIP4 domain-containing protein.	0.485
HCEG_00286	HCEG_04113	F0U8L9	F0UF41	SH3 domain-containing protein.	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.966
HCEG_00286	HCEG_04817	F0U8L9	F0UIJ7	SH3 domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.936
HCEG_00286	HCEG_04992	F0U8L9	F0UJN4	SH3 domain-containing protein.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.802
HCEG_00286	HCEG_05147	F0U8L9	F0UKH8	SH3 domain-containing protein.	Golgi to endosome transporter.	0.710
HCEG_00286	HCEG_05179	F0U8L9	F0UKL0	SH3 domain-containing protein.	Polarized growth protein.	0.717
HCEG_00286	HCEG_05990	F0U8L9	F0UNG0	SH3 domain-containing protein.	Uncharacterized protein; Belongs to the synaptobrevin family.	0.645
HCEG_00286	HCEG_06497	F0U8L9	F0UM85	SH3 domain-containing protein.	Osmosensor protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	0.496
HCEG_00286	HCEG_06653	F0U8L9	F0UMX1	SH3 domain-containing protein.	DUF1681 domain-containing protein.	0.900
HCEG_00286	HCEG_06746	F0U8L9	F0UN64	SH3 domain-containing protein.	Uncharacterized protein.	0.802
HCEG_00286	HCEG_07034	F0U8L9	F0UPS4	SH3 domain-containing protein.	Cytoskeleton assembly control protein.	0.667
HCEG_00286	HCEG_07250	F0U8L9	F0ULZ1	SH3 domain-containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.934