(24 nodes) Nervous system development network (Histoplasma capsulatum H88)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCEG_02116	MAP kinase. (542 aa)
	HCEG_02064	Homeobox transcription factor. (530 aa)
	HCEG_02838	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa)
	HCEG_01979	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (937 aa)
	HCEG_00372	MAP kinase; Belongs to the protein kinase superfamily. (498 aa)
	HCEG_01838	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (383 aa)
	HCEG_01706	Allantoinase. (575 aa)
	HCEG_01436	Predicted protein. (251 aa)
	HCEG_03641	Uncharacterized protein. (717 aa)
	HCEG_04817	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1676 aa)
	HCEG_04992	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (712 aa)
	SLX4	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (843 aa)
	HCEG_07250	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (253 aa)
	HCEG_07329	Uncharacterized protein. (654 aa)
	HCEG_06584	C6 finger domain-containing protein. (780 aa)
	HCEG_06746	Uncharacterized protein. (301 aa)
	HCEG_07058	Rac1 GTPase. (199 aa)
	HCEG_07441	Cofilin; Belongs to the actin-binding proteins ADF family. (131 aa)
	HCEG_07448	Protein kinase domain-containing protein. (724 aa)
	HCEG_07753	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (708 aa)
	HCEG_08320	Actin associated protein Wsp1. (670 aa)
	HCEG_08680	Uncharacterized protein. (145 aa)
	HCEG_04113	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (468 aa)
	HCEG_03358	Dual specificity mitogen-activated protein kinase dSOR1. (670 aa)

Your Current Organism:

Histoplasma capsulatum H88

NCBI taxonomy Id: 544711
Other names: Ajellomyces capsulatus H88, H. capsulatum H88

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCEG_00372	HCEG_01436	F0U908	F0U583	MAP kinase; Belongs to the protein kinase superfamily.	Predicted protein.	0.551
HCEG_00372	HCEG_01838	F0U908	F0U7W4	MAP kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.839
HCEG_00372	HCEG_02116	F0U908	F0UAN5	MAP kinase; Belongs to the protein kinase superfamily.	MAP kinase.	0.684
HCEG_00372	HCEG_03358	F0U908	F0UFI3	MAP kinase; Belongs to the protein kinase superfamily.	Dual specificity mitogen-activated protein kinase dSOR1.	0.618
HCEG_00372	HCEG_07058	F0U908	F0UPU8	MAP kinase; Belongs to the protein kinase superfamily.	Rac1 GTPase.	0.551
HCEG_01436	HCEG_00372	F0U583	F0U908	Predicted protein.	MAP kinase; Belongs to the protein kinase superfamily.	0.551
HCEG_01436	HCEG_01838	F0U583	F0U7W4	Predicted protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.692
HCEG_01436	HCEG_02116	F0U583	F0UAN5	Predicted protein.	MAP kinase.	0.551
HCEG_01436	HCEG_03358	F0U583	F0UFI3	Predicted protein.	Dual specificity mitogen-activated protein kinase dSOR1.	0.551
HCEG_01436	HCEG_03641	F0U583	F0UH79	Predicted protein.	Uncharacterized protein.	0.509
HCEG_01436	HCEG_04817	F0U583	F0UIJ7	Predicted protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.733
HCEG_01436	HCEG_04992	F0U583	F0UJN4	Predicted protein.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.569
HCEG_01436	HCEG_06584	F0U583	F0UMQ2	Predicted protein.	C6 finger domain-containing protein.	0.583
HCEG_01436	HCEG_06746	F0U583	F0UN64	Predicted protein.	Uncharacterized protein.	0.569
HCEG_01436	HCEG_07250	F0U583	F0ULZ1	Predicted protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.476
HCEG_01436	HCEG_07329	F0U583	F0UMC2	Predicted protein.	Uncharacterized protein.	0.509
HCEG_01436	HCEG_07448	F0U583	F0UQQ6	Predicted protein.	Protein kinase domain-containing protein.	0.509
HCEG_01436	HCEG_07753	F0U583	F0URL1	Predicted protein.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.569
HCEG_01436	HCEG_08320	F0U583	F0UT78	Predicted protein.	Actin associated protein Wsp1.	0.917
HCEG_01706	HCEG_01979	F0U6X3	F0U9U2	Allantoinase.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.504