(62 nodes) Phagosome network (Histoplasma capsulatum H88)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCEG_02932	Vacuolar sorting-associated protein. (285 aa)
	HCEG_01436	Predicted protein. (251 aa)
	HCEG_00720	Calnexin. (562 aa)
	HCEG_01552	Nulp1-pending protein. (724 aa)
	HCEG_01589	Mitochondrial initiation factor 2. (1027 aa)
	HCEG_00034	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	HCEG_00852	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (123 aa)
	HCEG_00875	6-phosphogluconate dehydrogenase. (317 aa)
	HCEG_00963	Mitochondrial import inner membrane translocase subunit tim9. (123 aa)
	HCEG_01014	Translocation complex subunit Sss1. (70 aa)
	HCEG_00241	PHD finger containing protein Phf1. (565 aa)
	HCEG_00246	ATP-dependent rRNA helicase RRP3; Belongs to the DEAD box helicase family. (485 aa)
	HCEG_01136	Protein kinase domain-containing protein. (1307 aa)
	HCEG_01156	GTP binding protein. (1486 aa)
	HCEG_00353	TPR_REGION domain-containing protein. (536 aa)
	HCEG_00387	Vacuolar sorting receptor. (313 aa)
	HCEG_00404	Predicted protein. (304 aa)
	HCEG_00477	GTP-binding protein ypt5. (217 aa)
	HCEG_01299	FAD-binding FR-type domain-containing protein. (369 aa)
	HCEG_01962	Phosphatidylinositol-4-phosphate 5-kinase fab1. (2553 aa)
	HCEG_02148	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (478 aa)
	HCEG_02161	FRE family ferric-chelate reductase. (758 aa)
	HCEG_02403	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (859 aa)
	HCEG_03230	Uncharacterized protein. (425 aa)
	HCEG_02539	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (393 aa)
	HCEG_02550	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
	HCEG_02725	Ferric-chelate reductase. (603 aa)
	HCEG_03753	Vacuolar biogenesis protein. (317 aa)
	HCEG_03777	Vacuolar ATP synthase subunit D. (268 aa)
	HCEG_03796	Dynein heavy chain. (4361 aa)
	HCEG_03849	Cytoplasmic dynein intermediate chain. (692 aa)
	HCEG_04141	Protein transporter SEC61 alpha subunit. (479 aa)
	HCEG_04223	F-box domain-containing protein. (595 aa)
	HCEG_03437	Metalloreductase. (618 aa)
	HCEG_03550	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family. (365 aa)
	HCEG_04474	NADPH oxidase regulator NoxR. (547 aa)
	HCEG_04475	Syntaxin. (399 aa)
	HCEG_05503	Translocon protein Sec61beta. (164 aa)
	HCEG_05059	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
	HCEG_05959	Coronin; Belongs to the WD repeat coronin family. (558 aa)
	HCEG_04577	Uncharacterized protein. (503 aa)
	HCEG_04578	Ras-like GTP-binding protein RYL2. (303 aa)
	HCEG_06453	Phosphatidylinositol 3-kinase VPS34. (912 aa)
	HCEG_06477	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (149 aa)
	HCEG_06483	Dynein light intermediate chain. (543 aa)
	HCEG_06121	ATP synthase alpha subunit vacuolar. (691 aa)
	HCEG_07058	Rac1 GTPase. (199 aa)
	HCEG_07135	NADPH oxidase isoform 2. (552 aa)
	HCEG_07397	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
	HCEG_08298	Ferric reductase. (787 aa)
	HCEG_08307	Vacuolar ATP synthase subunit E. (238 aa)
	HCEG_08395	Presequence translocated-associated motor subunit pam17. (296 aa)
	HCEG_08629	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (755 aa)
	HCEG_08696	Uncharacterized protein. (1019 aa)
	HCEG_08800	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (504 aa)
	HCEG_08965	NADPH oxidase. (548 aa)
	HCEG_09007	Mis6 domain-containing protein. (724 aa)
	HCEG_09011	Protein transporter sec22; Belongs to the synaptobrevin family. (215 aa)
	HCEG_09120	Ferric reductase transmembrane component 3. (702 aa)
	HCEG_09181	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (269 aa)
	HCEG_09182	Uncharacterized protein. (684 aa)
	HCEG_09212	Uncharacterized protein. (333 aa)

Your Current Organism:

Histoplasma capsulatum H88

NCBI taxonomy Id: 544711
Other names: Ajellomyces capsulatus H88, H. capsulatum H88

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCEG_00034	HCEG_00720	F0U6N3	F0U5R3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Calnexin.	0.410
HCEG_00034	HCEG_01436	F0U6N3	F0U583	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Predicted protein.	0.785
HCEG_00034	HCEG_02550	F0U6N3	F0UCQ9	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.998
HCEG_00034	HCEG_03753	F0U6N3	F0UE08	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Vacuolar biogenesis protein.	0.919
HCEG_00034	HCEG_03796	F0U6N3	F0UE51	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Dynein heavy chain.	0.982
HCEG_00034	HCEG_03849	F0U6N3	F0UEA4	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Cytoplasmic dynein intermediate chain.	0.985
HCEG_00034	HCEG_06483	F0U6N3	F0UM71	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Dynein light intermediate chain.	0.920
HCEG_00034	HCEG_07058	F0U6N3	F0UPU8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Rac1 GTPase.	0.741
HCEG_00034	HCEG_07397	F0U6N3	F0UQK5	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.919
HCEG_00034	HCEG_08800	F0U6N3	F0UUK8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.565
HCEG_00034	HCEG_09007	F0U6N3	F0UV65	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Mis6 domain-containing protein.	0.981
HCEG_00241	HCEG_00875	F0U8C1	F0U6T4	PHD finger containing protein Phf1.	6-phosphogluconate dehydrogenase.	0.678
HCEG_00241	HCEG_04475	F0U8C1	F0UH73	PHD finger containing protein Phf1.	Syntaxin.	0.601
HCEG_00353	HCEG_00404	F0U8Y9	F0U992	TPR_REGION domain-containing protein.	Predicted protein.	0.538
HCEG_00353	HCEG_01299	F0U8Y9	F0U9P8	TPR_REGION domain-containing protein.	FAD-binding FR-type domain-containing protein.	0.538
HCEG_00353	HCEG_01436	F0U8Y9	F0U583	TPR_REGION domain-containing protein.	Predicted protein.	0.562
HCEG_00353	HCEG_02161	F0U8Y9	F0UAT0	TPR_REGION domain-containing protein.	FRE family ferric-chelate reductase.	0.538
HCEG_00353	HCEG_02725	F0U8Y9	F0UDC6	TPR_REGION domain-containing protein.	Ferric-chelate reductase.	0.538
HCEG_00353	HCEG_03437	F0U8Y9	F0UG16	TPR_REGION domain-containing protein.	Metalloreductase.	0.538
HCEG_00353	HCEG_07058	F0U8Y9	F0UPU8	TPR_REGION domain-containing protein.	Rac1 GTPase.	0.562