40 items (Histoplasma capsulatum H143) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	HCDG_02950	Uncharacterized protein; Belongs to the CGI121/TPRKB family. (206 aa)
	HCDG_02275	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (377 aa)
	HCDG_02195	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (723 aa)
	HCDG_01961	Checkpoint protein; Belongs to the HUS1 family. (364 aa)
	HCDG_00447	Piwi domain-containing protein. (168 aa)
	HCDG_01310	Uncharacterized protein. (863 aa)
	HCDG_01275	Uncharacterized protein. (155 aa)
	HCDG_01274	RNA-dependent RNA polymerase. (396 aa)
	HCDG_01273	Uncharacterized protein. (196 aa)
	HCDG_00022	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (781 aa)
	HCDG_01071	Telomere length regulator protein. (1526 aa)
	HCDG_01063	SHREC complex subunit Mit1. (676 aa)
	HCDG_00823	QDE2 protein. (1038 aa)
	HCDG_09263	Ku70. (573 aa)
	HCDG_09244	Uncharacterized protein. (188 aa)
	HCDG_08540	PHD transcription factor. (900 aa)
	HCDG_08528	Eukaryotic translation initiation factor 2c. (902 aa)
	HCDG_08788	YEATS family protein. (252 aa)
	HCDG_08381	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (541 aa)
	HCDG_07428	Single-stranded DNA binding protein p30 subunit. (265 aa)
	HCDG_07138	Telomeric DNA-binding factor trf1. (601 aa)
	HCDG_07521	Serine/threonine protein kinase. (339 aa)
	HCDG_06843	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (530 aa)
	LSM3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (98 aa)
	HCDG_06775	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2777 aa)
	HCDG_06774	Nuclear pore complex subunit Nup192; Belongs to the cullin family. (2454 aa)
	HCDG_06771	GATA transcription factor. (901 aa)
	HCDG_06587	Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (557 aa)
	HCDG_06104	DNA replication ATP-dependent helicase dna2. (1609 aa)
	HCDG_06090	Chromatin regulatory protein sir2. (515 aa)
	HCDG_05767	RNA-dependent RNA polymerase. (1240 aa)
	HCDG_05045	Chromo domain-containing protein. (524 aa)
	HCDG_04683	DNA helicase; Belongs to the MCM family. (718 aa)
	HCDG_04543	C2H2 finger domain-containing protein. (1475 aa)
	HCDG_04476	DNA helicase; Belongs to the MCM family. (857 aa)
	HCDG_04362	OB-fold nucleic acid binding domain-containing protein. (280 aa)
	HCDG_04361	Stc1 domain-containing protein. (298 aa)
	HCDG_04074	Heterochromatin protein HP1. (246 aa)
	HCDG_03473	Telomere-binding alpha subunit central domain-containing protein. (653 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (698 aa)

Your Current Organism:

Histoplasma capsulatum H143

NCBI taxonomy Id: 544712
Other names: Ajellomyces capsulatus H143, H. capsulatum H143

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCDG_00022	HCDG_01063	C6H3C8	C6H2Y1	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	SHREC complex subunit Mit1.	0.773
HCDG_00022	HCDG_01310	C6H3C8	C6H3Y9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Uncharacterized protein.	0.453
HCDG_00022	HCDG_02275	C6H3C8	C6H774	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.744
HCDG_00022	HCDG_04074	C6H3C8	C6HCZ3	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Heterochromatin protein HP1.	0.675
HCDG_00022	HCDG_04543	C6H3C8	C6HF20	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	C2H2 finger domain-containing protein.	0.704
HCDG_00022	HCDG_05045	C6H3C8	C6HGF4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Chromo domain-containing protein.	0.554
HCDG_00022	HCDG_06090	C6H3C8	C6HJ56	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Chromatin regulatory protein sir2.	0.693
HCDG_00447	HCDG_04074	C6H5C6	C6HCZ3	Piwi domain-containing protein.	Heterochromatin protein HP1.	0.494
HCDG_00447	HCDG_04361	C6H5C6	C6HDT0	Piwi domain-containing protein.	Stc1 domain-containing protein.	0.450
HCDG_00447	HCDG_05045	C6H5C6	C6HGF4	Piwi domain-containing protein.	Chromo domain-containing protein.	0.486
HCDG_00823	HCDG_04074	C6H291	C6HCZ3	QDE2 protein.	Heterochromatin protein HP1.	0.494
HCDG_00823	HCDG_04361	C6H291	C6HDT0	QDE2 protein.	Stc1 domain-containing protein.	0.450
HCDG_00823	HCDG_05045	C6H291	C6HGF4	QDE2 protein.	Chromo domain-containing protein.	0.486
HCDG_01063	HCDG_00022	C6H2Y1	C6H3C8	SHREC complex subunit Mit1.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.773
HCDG_01063	HCDG_02275	C6H2Y1	C6H774	SHREC complex subunit Mit1.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.679
HCDG_01063	HCDG_04074	C6H2Y1	C6HCZ3	SHREC complex subunit Mit1.	Heterochromatin protein HP1.	0.900
HCDG_01063	HCDG_04543	C6H2Y1	C6HF20	SHREC complex subunit Mit1.	C2H2 finger domain-containing protein.	0.974
HCDG_01063	HCDG_05045	C6H2Y1	C6HGF4	SHREC complex subunit Mit1.	Chromo domain-containing protein.	0.880
HCDG_01063	HCDG_06774	C6H2Y1	C6HKP3	SHREC complex subunit Mit1.	Nuclear pore complex subunit Nup192; Belongs to the cullin family.	0.640
HCDG_01063	HCDG_07428	C6H2Y1	C6HMW2	SHREC complex subunit Mit1.	Single-stranded DNA binding protein p30 subunit.	0.606