62 items (Histoplasma capsulatum H143) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	HCDG_00480	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1072 aa)
	HCDG_04522	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (439 aa)
	HCDG_04521	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (582 aa)
	HCDG_04958	Isovaleryl-CoA dehydrogenase. (434 aa)
	HCDG_04957	Methylcrotonoyl-CoA carboxylase subunit beta. (575 aa)
	HCDG_04248	Aspartylglucosaminidase. (572 aa)
	HCDG_04143	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (450 aa)
	HCDG_04107	8-amino-7-oxononanoate synthase. (412 aa)
	HCDG_04100	Homogentisate 1,2-dioxygenase. (454 aa)
	HCDG_04098	4-hydroxyphenylpyruvate dioxygenase. (402 aa)
	HCDG_04047	Alanine transaminase. (531 aa)
	HCDG_02959	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (530 aa)
	HCDG_02924	Threonine aldolase. (364 aa)
	HCDG_02831	Beta-lactamase. (399 aa)
	HCDG_02817	Hydroxyquinol 1,2-dioxygenase. (311 aa)
	HCDG_02740	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (143 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (510 aa)
	HCDG_00668	Cysteine dioxygenase. (281 aa)
	HCDG_00704	Sarcosine oxidase. (430 aa)
	HCDG_00748	Threonine dehydratase. (562 aa)
	HCDG_00760	Succinate-semialdehyde dehydrogenase. (497 aa)
	HCDG_00814	Retinal dehydrogenase; Belongs to the aldehyde dehydrogenase family. (536 aa)
	HCDG_00933	Aspartate aminotransferase. (383 aa)
	HCDG_00996	Methylmalonate-semialdehyde dehydrogenase. (538 aa)
	HCDG_01233	L-allo-threonine aldolase. (414 aa)
	HCDG_01317	Succinate semialdehyde dehydrogenase. (500 aa)
	HCDG_00317	L-serine dehydratase. (359 aa)
	HCDG_02475	Ornithine aminotransferase. (384 aa)
	HCDG_04529	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (633 aa)
	HCDG_01862	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (555 aa)
	HCDG_02260	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (471 aa)
	HCDG_02395	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (281 aa)
	HCDG_02411	APSES transcription factor Xbp1. (484 aa)
	HCDG_02436	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. (512 aa)
	HCDG_09496	Threonine aldolase. (374 aa)
	HCDG_09384	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (590 aa)
	HCDG_09342	Aldedh domain-containing protein. (142 aa)
	HCDG_09106	2-oxoisovalerate dehydrogenase. (390 aa)
	HCDG_08673	Fructosyl amino acid oxidasesarcosine oxidase. (333 aa)
	HCDG_08629	Uncharacterized protein. (138 aa)
	HCDG_08269	Alcohol dehydrogenase. (353 aa)
	HCDG_08202	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (504 aa)
	HCDG_07998	Dihydrolipoamide S-succinyltransferase. (465 aa)
	HCDG_07880	Aldehyde dehydrogenase. (460 aa)
	HCDG_07854	Nucleoside-diphosphate-sugar epimerase. (329 aa)
	HCDG_07641	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (491 aa)
	HCDG_07637	Fumarylacetoacetase. (429 aa)
	HCDG_07451	Uncharacterized protein. (279 aa)
	HCDG_07442	3-hydroxyisobutyrate dehydrogenase. (286 aa)
	HCDG_07516	Indoleamine 2,3-dioxygenase. (482 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (192 aa)
	HCDG_06748	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (465 aa)
	HCDG_06465	Hydroxymethylglutaryl-CoA lyase. (355 aa)
	HCDG_06309	NAD-specific glutamate dehydrogenase. (484 aa)
	HCDG_06307	Uncharacterized protein. (167 aa)
	HCDG_06080	Branched-chain alpha-keto acid lipoamide acyltransferase. (223 aa)
	HCDG_05921	4-hydroxyphenylpyruvate dioxygenase. (428 aa)
	HCDG_05886	Alpha/beta hydrolase fold protein. (333 aa)
	HCDG_05845	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (552 aa)
	HCDG_06193	Uncharacterized protein. (124 aa)
	HCDG_06170	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (516 aa)
	HCDG_05646	Kynureninase. (320 aa)

Your Current Organism:

Histoplasma capsulatum H143

NCBI taxonomy Id: 544712
Other names: Ajellomyces capsulatus H143, H. capsulatum H143

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	C6HL90	C6H8K7	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.814
BNA1	HCDG_05646	C6HL90	C6HHG5	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase.	0.979
BNA1	HCDG_07516	C6HL90	C6HLP7	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Indoleamine 2,3-dioxygenase.	0.597
BNA4	BNA1	C6H8K7	C6HL90	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.814
BNA4	HCDG_00814	C6H8K7	C6H282	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Retinal dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.446
BNA4	HCDG_02395	C6H8K7	C6H7J4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.746
BNA4	HCDG_04100	C6H8K7	C6HD19	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Homogentisate 1,2-dioxygenase.	0.526
BNA4	HCDG_04529	C6H8K7	C6HF06	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.446
BNA4	HCDG_05646	C6H8K7	C6HHG5	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase.	0.991
BNA4	HCDG_05886	C6H8K7	C6HIK2	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Alpha/beta hydrolase fold protein.	0.421
BNA4	HCDG_07516	C6H8K7	C6HLP7	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Indoleamine 2,3-dioxygenase.	0.541
BNA4	HCDG_07637	C6H8K7	C6HN56	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Fumarylacetoacetase.	0.563
BNA4	HCDG_07880	C6H8K7	C6HNU9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aldehyde dehydrogenase.	0.446
HCDG_00317	HCDG_00748	C6H4Z6	C6H216	L-serine dehydratase.	Threonine dehydratase.	0.912
HCDG_00317	HCDG_00760	C6H4Z6	C6H228	L-serine dehydratase.	Succinate-semialdehyde dehydrogenase.	0.575
HCDG_00317	HCDG_00814	C6H4Z6	C6H282	L-serine dehydratase.	Retinal dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.479
HCDG_00317	HCDG_01233	C6H4Z6	C6H3I0	L-serine dehydratase.	L-allo-threonine aldolase.	0.929
HCDG_00317	HCDG_01317	C6H4Z6	C6H3Z6	L-serine dehydratase.	Succinate semialdehyde dehydrogenase.	0.501
HCDG_00317	HCDG_02260	C6H4Z6	C6H759	L-serine dehydratase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.926
HCDG_00317	HCDG_02924	C6H4Z6	C6H9P3	L-serine dehydratase.	Threonine aldolase.	0.866