node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | HCDG_00551 | C6HQJ2 | C6H1G9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.562 |
FEN1 | HCDG_03938 | C6HQJ2 | C6HB56 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.637 |
FEN1 | HCDG_04607 | C6HQJ2 | C6HF84 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.487 |
FEN1 | HCDG_06104 | C6HQJ2 | C6HJ70 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA replication ATP-dependent helicase dna2. | 0.980 |
FEN1 | HCDG_06639 | C6HQJ2 | C6HKA8 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.487 |
FEN1 | HCDG_08026 | C6HQJ2 | C6HP95 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Exonuclease. | 0.912 |
FEN1 | HCDG_08698 | C6HQJ2 | C6HQM6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.753 |
FEN1 | SLX1 | C6HQJ2 | C6HED3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.732 |
HCDG_00447 | HCDG_03406 | C6H5C6 | C6HBK7 | Piwi domain-containing protein. | RNase III domain-containing protein. | 0.789 |
HCDG_00447 | HCDG_05122 | C6H5C6 | C6HGN1 | Piwi domain-containing protein. | RNase3 domain-containing protein. | 0.811 |
HCDG_00447 | HCDG_05291 | C6H5C6 | C6HFV1 | Piwi domain-containing protein. | 60S ribosomal protein L3. | 0.762 |
HCDG_00447 | HCDG_06620 | C6H5C6 | C6HK89 | Piwi domain-containing protein. | Dicer-like protein. | 0.823 |
HCDG_00447 | HCDG_06621 | C6H5C6 | C6HK90 | Piwi domain-containing protein. | Dicer-like protein. | 0.823 |
HCDG_00447 | HCDG_06890 | C6H5C6 | C6HL09 | Piwi domain-containing protein. | ATP-dependent helicase DCL1. | 0.823 |
HCDG_00447 | HCDG_06891 | C6H5C6 | C6HL10 | Piwi domain-containing protein. | ATP-dependent helicase DCL1. | 0.823 |
HCDG_00551 | FEN1 | C6H1G9 | C6HQJ2 | Uncharacterized protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.562 |
HCDG_00551 | HCDG_08026 | C6H1G9 | C6HP95 | Uncharacterized protein. | Exonuclease. | 0.441 |
HCDG_00551 | HCDG_08698 | C6H1G9 | C6HQM6 | Uncharacterized protein. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.995 |
HCDG_00823 | HCDG_03406 | C6H291 | C6HBK7 | QDE2 protein. | RNase III domain-containing protein. | 0.789 |
HCDG_00823 | HCDG_05122 | C6H291 | C6HGN1 | QDE2 protein. | RNase3 domain-containing protein. | 0.811 |