32 items (Histoplasma capsulatum H143) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCDG_06047	Uncharacterized protein. (605 aa)
	HCDG_00967	DNA repair protein RAD50. (1421 aa)
	HCDG_01369	DNA ligase. (899 aa)
	HCDG_01386	High-affinity nickel transporter. (694 aa)
	HCDG_00325	DNA polymerase delta small subunit. (565 aa)
	HCDG_01727	DNA polymerase delta subunit 4. (214 aa)
	HCDG_02191	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (630 aa)
	HCDG_02270	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2111 aa)
	HCDG_01565	Uncharacterized protein. (314 aa)
	HCDG_02798	Polymerase. (717 aa)
	HCDG_02856	Uncharacterized protein. (168 aa)
	HCDG_03034	Telomere_reg-2 domain-containing protein. (940 aa)
	HCDG_03248	Vezatin domain-containing protein. (314 aa)
	HCDG_03249	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (548 aa)
	HCDG_03318	DNA polymerase epsilon subunit B. (644 aa)
	HCDG_03519	DNA polymerase. (1053 aa)
	HCDG_03605	DNA ligase. (844 aa)
	HCDG_04768	Uncharacterized protein. (171 aa)
	HCDG_04674	ATP-dependent DNA ligase domain-containing protein. (1086 aa)
	HCDG_05443	Uncharacterized protein. (108 aa)
	HCDG_05524	DNA polymerase kappa. (604 aa)
	HCDG_05757	Uncharacterized protein. (320 aa)
	HCDG_06236	DNA polymerase. (1458 aa)
	HCDG_05959	DNA polymerase iota. (730 aa)
	HCDG_06409	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1111 aa)
	HCDG_06743	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (633 aa)
	HCDG_06778	DNA polymerase gamma. (1084 aa)
	HCDG_06853	DNA ligase. (940 aa)
	HCDG_06958	Uncharacterized protein. (84 aa)
	HCDG_07529	DNA polymerase. (1503 aa)
	HCDG_07321	Mitotic spindle checkpoint protein. (357 aa)
	HCDG_08381	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (541 aa)

Your Current Organism:

Histoplasma capsulatum H143

NCBI taxonomy Id: 544712
Other names: Ajellomyces capsulatus H143, H. capsulatum H143

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCDG_00325	HCDG_01369	C6H504	C6H4D0	DNA polymerase delta small subunit.	DNA ligase.	0.782
HCDG_00325	HCDG_01386	C6H504	C6H4E7	DNA polymerase delta small subunit.	High-affinity nickel transporter.	0.595
HCDG_00325	HCDG_01727	C6H504	C6H5M6	DNA polymerase delta small subunit.	DNA polymerase delta subunit 4.	0.902
HCDG_00325	HCDG_02191	C6H504	C6H6Z0	DNA polymerase delta small subunit.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.650
HCDG_00325	HCDG_02270	C6H504	C6H769	DNA polymerase delta small subunit.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.974
HCDG_00325	HCDG_02798	C6H504	C6H9B7	DNA polymerase delta small subunit.	Polymerase.	0.662
HCDG_00325	HCDG_03248	C6H504	C6HAL7	DNA polymerase delta small subunit.	Vezatin domain-containing protein.	0.980
HCDG_00325	HCDG_03249	C6H504	C6HAL8	DNA polymerase delta small subunit.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.980
HCDG_00325	HCDG_03318	C6H504	C6HAT7	DNA polymerase delta small subunit.	DNA polymerase epsilon subunit B.	0.920
HCDG_00325	HCDG_03519	C6H504	C6HBX0	DNA polymerase delta small subunit.	DNA polymerase.	0.999
HCDG_00325	HCDG_03605	C6H504	C6HC56	DNA polymerase delta small subunit.	DNA ligase.	0.782
HCDG_00325	HCDG_04674	C6H504	C6HFF1	DNA polymerase delta small subunit.	ATP-dependent DNA ligase domain-containing protein.	0.721
HCDG_00325	HCDG_05524	C6H504	C6HH43	DNA polymerase delta small subunit.	DNA polymerase kappa.	0.795
HCDG_00325	HCDG_05757	C6H504	C6HHS6	DNA polymerase delta small subunit.	Uncharacterized protein.	0.953
HCDG_00325	HCDG_05959	C6H504	C6HIS5	DNA polymerase delta small subunit.	DNA polymerase iota.	0.791
HCDG_00325	HCDG_06236	C6H504	C6HI86	DNA polymerase delta small subunit.	DNA polymerase.	0.954
HCDG_00325	HCDG_06409	C6H504	C6HJM8	DNA polymerase delta small subunit.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.821
HCDG_00325	HCDG_06743	C6H504	C6HKL2	DNA polymerase delta small subunit.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.953
HCDG_00325	HCDG_06853	C6H504	C6HKX2	DNA polymerase delta small subunit.	DNA ligase.	0.721
HCDG_00325	HCDG_07321	C6H504	C6HMK5	DNA polymerase delta small subunit.	Mitotic spindle checkpoint protein.	0.968