STRINGSTRING
HCDG_06409 HCDG_06409 HCDG_02765 HCDG_02765 HCDG_02784 HCDG_02784 HCDG_02845 HCDG_02845 HCDG_02854 HCDG_02854 HCDG_02921 HCDG_02921 HCDG_02923 HCDG_02923 HCDG_02969 HCDG_02969 HCDG_02977 HCDG_02977 HCDG_02982 HCDG_02982 HCDG_03012 HCDG_03012 HCDG_03023 HCDG_03023 HCDG_03174 HCDG_03174 HCDG_03183 HCDG_03183 HCDG_03189 HCDG_03189 HCDG_03249 HCDG_03249 HCDG_03279 HCDG_03279 HCDG_03875 HCDG_03875 HCDG_03985 HCDG_03985 MCM7 MCM7 HCDG_03519 HCDG_03519 HCDG_03614 HCDG_03614 HCDG_03720 HCDG_03720 HCDG_03827 HCDG_03827 HCDG_04146 HCDG_04146 HCDG_04292 HCDG_04292 HCDG_04476 HCDG_04476 HCDG_04922 HCDG_04922 HCDG_04683 HCDG_04683 HCDG_04743 HCDG_04743 HCDG_05427 HCDG_05427 HCDG_05527 HCDG_05527 HCDG_05691 HCDG_05691 HCDG_05707 HCDG_05707 HCDG_05735 HCDG_05735 HCDG_06236 HCDG_06236 HCDG_05912 HCDG_05912 HCDG_05942 HCDG_05942 HCDG_06000 HCDG_06000 HCDG_06101 HCDG_06101 HCDG_06340 HCDG_06340 HCDG_06396 HCDG_06396 HCDG_02671 HCDG_02671 HCDG_06565 HCDG_06565 HCDG_06583 HCDG_06583 HCDG_06627 HCDG_06627 HCDG_06630 HCDG_06630 PIF1 PIF1 HCDG_06795 HCDG_06795 HCDG_07529 HCDG_07529 HCDG_07536 HCDG_07536 HCDG_07138 HCDG_07138 HCDG_07227 HCDG_07227 HCDG_07239 HCDG_07239 HCDG_07461 HCDG_07461 HCDG_07663 HCDG_07663 HCDG_07835 HCDG_07835 HCDG_07859 HCDG_07859 HCDG_07920 HCDG_07920 HCDG_08000 HCDG_08000 HCDG_08033 HCDG_08033 HCDG_08381 HCDG_08381 HCDG_08902 HCDG_08902 HCDG_08702 HCDG_08702 HCDG_08820 HCDG_08820 HCDG_08836 HCDG_08836 HCDG_08532 HCDG_08532 HCDG_08601 HCDG_08601 HCDG_08981 HCDG_08981 HCDG_09017 HCDG_09017 HCDG_09289 HCDG_09289 HCDG_00649 HCDG_00649 HCDG_00837 HCDG_00837 HCDG_01015 HCDG_01015 HCDG_01183 HCDG_01183 PIM1 PIM1 HCDG_00020 HCDG_00020 HCDG_00027 HCDG_00027 HCDG_01283 HCDG_01283 HCDG_00183 HCDG_00183 HCDG_00349 HCDG_00349 HCDG_00421 HCDG_00421 HCDG_01764 HCDG_01764 HCDG_01765 HCDG_01765 HCDG_01822 HCDG_01822 HCDG_02010 HCDG_02010 HCDG_02056 HCDG_02056 HCDG_02162 HCDG_02162 HCDG_02188 HCDG_02188 HCDG_02191 HCDG_02191 HCDG_02195 HCDG_02195 HCDG_02270 HCDG_02270 HCDG_02311 HCDG_02311 HCDG_02339 HCDG_02339 HCDG_02391 HCDG_02391 HCDG_02412 HCDG_02412 HCDG_01505 HCDG_01505 HCDG_01590 HCDG_01590
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HCDG_06409DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1111 aa)
HCDG_02765Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
HCDG_02784Homeobox transcription factor. (732 aa)
HCDG_02845C6 transcription factor. (584 aa)
HCDG_02854C6 transcription factor. (1008 aa)
HCDG_02921C6 zinc finger protein. (851 aa)
HCDG_02923C6 transcription factor. (704 aa)
HCDG_02969Forkhead domain-containing protein. (355 aa)
HCDG_02977MYB DNA-binding domain-containing protein. (384 aa)
HCDG_02982MYB DNA-binding domain-containing protein. (212 aa)
HCDG_03012Fungal specific transcription factor. (818 aa)
HCDG_03023Acetamidase regulatory protein. (749 aa)
HCDG_03174MYB family conidiophore development protein FlbD. (389 aa)
HCDG_03183DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (504 aa)
HCDG_03189DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (909 aa)
HCDG_03249Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (548 aa)
HCDG_03279HMG box protein. (390 aa)
HCDG_03875C6 transcription factor. (833 aa)
HCDG_03985Homeobox and C2H2 transcription factor. (844 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (698 aa)
HCDG_03519DNA polymerase. (1053 aa)
HCDG_03614Forkhead box protein C2. (735 aa)
HCDG_03720Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
HCDG_03827Fungal specific transcription factor. (624 aa)
HCDG_04146Zn(2)-C6 fungal-type domain-containing protein. (669 aa)
HCDG_04292MYB DNA-binding domain-containing protein. (50 aa)
HCDG_04476DNA helicase; Belongs to the MCM family. (857 aa)
HCDG_04922Zn(2)-C6 fungal-type domain-containing protein. (645 aa)
HCDG_04683DNA helicase; Belongs to the MCM family. (718 aa)
HCDG_04743C6 transcription factor. (1005 aa)
HCDG_05427Forkhead box protein L2. (793 aa)
HCDG_05527DsDNA-binding protein PDCD5. (131 aa)
HCDG_05691Transcriptional regulator PacG/VIB-1. (585 aa)
HCDG_05707C6 transcription factor. (930 aa)
HCDG_05735NDT80 domain-containing protein. (631 aa)
HCDG_06236DNA polymerase. (1458 aa)
HCDG_05912HMG box protein. (487 aa)
HCDG_05942HMG box transcription factor. (659 aa)
HCDG_06000Glucoamylase. (1360 aa)
HCDG_06101Binuclear zinc transcription factor. (797 aa)
HCDG_06340DNA helicase; Belongs to the MCM family. (1758 aa)
HCDG_06396Fungal specific transcription factor. (962 aa)
HCDG_02671Homeobox transcription factor. (530 aa)
HCDG_06565Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
HCDG_06583HMG box domain-containing protein. (350 aa)
HCDG_06627PriB. (758 aa)
HCDG_06630C6 zinc finger protein. (892 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (794 aa)
HCDG_06795Zn(2)-C6 fungal-type domain-containing protein. (490 aa)
HCDG_07529DNA polymerase. (1503 aa)
HCDG_07536Alpha-box mating type protein. (404 aa)
HCDG_07138Telomeric DNA-binding factor trf1. (601 aa)
HCDG_07227DNA helicase; Belongs to the MCM family. (965 aa)
HCDG_07239C6 transcription factor. (997 aa)
HCDG_07461DNA replication licensing factor mcm2; Belongs to the MCM family. (542 aa)
HCDG_07663C6 transcription factor. (1135 aa)
HCDG_07835C6 transcription factor. (810 aa)
HCDG_07859Helix-loop-helix DNA-binding domain-containing protein. (105 aa)
HCDG_07920HMG box domain-containing protein. (279 aa)
HCDG_08000Histone H2A; Belongs to the histone H2A family. (134 aa)
HCDG_08033C6 transcription factor. (655 aa)
HCDG_08381Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (541 aa)
HCDG_08902H15 domain-containing protein. (199 aa)
HCDG_08702MYB DNA-binding domain-containing protein. (289 aa)
HCDG_08820Homeobox domain-containing protein. (348 aa)
HCDG_08836Homeobox domain-containing protein. (727 aa)
HCDG_08532C6 transcription factor. (946 aa)
HCDG_08601Nucleosome binding protein. (102 aa)
HCDG_08981MADS box transcription factor Mcm1. (238 aa)
HCDG_09017Fungal specific transcription factor. (811 aa)
HCDG_09289SsDNA binding protein. (140 aa)
HCDG_00649Zinc finger transcription factor 1. (970 aa)
HCDG_00837Cutinase transcription factor 1 alpha. (718 aa)
HCDG_01015Amine oxidase. (1080 aa)
HCDG_01183DNA-binding protein. (409 aa)
PIM1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1080 aa)
HCDG_00020Heat shock transcription factor. (206 aa)
HCDG_00027Histone H2A; Belongs to the histone H2A family. (138 aa)
HCDG_01283MYB DNA-binding domain-containing protein. (656 aa)
HCDG_00183SRF-type transcription factor RlmA. (636 aa)
HCDG_00349HSF-type DNA-binding domain-containing protein. (518 aa)
HCDG_00421Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (720 aa)
HCDG_01764Homeobox transcription factor. (200 aa)
HCDG_01765Homeobox transcription factor. (247 aa)
HCDG_01822Acetate regulatory DNA binding protein facB. (1024 aa)
HCDG_02010Histone H3. (181 aa)
HCDG_02056Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (298 aa)
HCDG_02162DNA damage-binding protein CMR1; DNA-binding protein that binds to both single- and double- stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes. (541 aa)
HCDG_02188Fungal specific transcription factor. (871 aa)
HCDG_02191DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (630 aa)
HCDG_02195ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (723 aa)
HCDG_02270DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2111 aa)
HCDG_02311DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (941 aa)
HCDG_02339Forkhead domain-containing protein. (1166 aa)
HCDG_02391HMG box domain-containing protein. (321 aa)
HCDG_02412DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1737 aa)
HCDG_01505Fungal specific transcription factor. (760 aa)
HCDG_01590DNA-binding protein. (674 aa)
Your Current Organism:
Histoplasma capsulatum H143
NCBI taxonomy Id: 544712
Other names: Ajellomyces capsulatus H143, H. capsulatum H143
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