44 items (Histoplasma capsulatum H143) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HCDG_02245	Allantoinase. (452 aa)
	HCDG_00623	Uncharacterized protein. (443 aa)
	HCDG_00634	MAP kinase skh1/pek1; Belongs to the protein kinase superfamily. (344 aa)
	HCDG_00646	Beta-glucosidase; Belongs to the glycosyl hydrolase 3 family. (845 aa)
	HCDG_00951	Polyubiquitin. (305 aa)
	HCDG_00119	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (712 aa)
	HCDG_00183	SRF-type transcription factor RlmA. (636 aa)
	HCDG_01382	Uncharacterized protein. (229 aa)
	HCDG_00294	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1600 aa)
	HCDG_01921	Glycosyl hydrolase. (959 aa)
	HCDG_01577	Uncharacterized protein. (252 aa)
	HCDG_02569	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (937 aa)
	HCDG_02671	Homeobox transcription factor. (530 aa)
	SLX4	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (847 aa)
	HCDG_03835	Ankyrin repeat protein. (1419 aa)
	HCDG_03741	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa)
	HCDG_03749	Protein kinase domain-containing protein. (121 aa)
	HCDG_04150	Beta-glucosidase; Belongs to the glycosyl hydrolase 3 family. (753 aa)
	HCDG_04245	CS antigen. (145 aa)
	HCDG_04426	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
	HCDG_04954	Triacylglycerol lipase. (519 aa)
	HCDG_04980	Ribosomal protein L24E. (673 aa)
	HCDG_04539	Protein kinase. (396 aa)
	HCDG_05337	C6 finger domain-containing protein. (848 aa)
	HCDG_05398	Calcium channel subunit Mid1. (558 aa)
	HCDG_05077	Cofilin; Belongs to the actin-binding proteins ADF family. (131 aa)
	HCDG_05084	Protein kinase domain-containing protein. (700 aa)
	HCDG_05217	Uncharacterized protein. (388 aa)
	HCDG_05647	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (708 aa)
	HCDG_06299	Transcriptional co-activator. (420 aa)
	HCDG_06738	Uncharacterized protein. (733 aa)
	HCDG_07556	Rac1 GTPase. (188 aa)
	HCDG_07253	Uncharacterized protein. (301 aa)
	HCDG_07326	Mitochondrial carrier; Belongs to the mitochondrial carrier (TC 2.A.29) family. (583 aa)
	HCDG_08126	Uncharacterized protein. (396 aa)
	HCDG_08243	Calcium/calmodulin dependent protein kinase. (206 aa)
	HCDG_08732	Uncharacterized protein. (676 aa)
	HCDG_08813	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (253 aa)
	HCDG_08429	Triacylglycerol lipase. (490 aa)
	HCDG_08997	Actin associated protein Wsp1. (610 aa)
	HCDG_09033	MAP kinase Hogp. (252 aa)
	HCDG_09294	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (468 aa)
	HCDG_09476	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	HCDG_12011	NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (202 aa)

Your Current Organism:

Histoplasma capsulatum H143

NCBI taxonomy Id: 544712
Other names: Ajellomyces capsulatus H143, H. capsulatum H143

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCDG_00119	HCDG_00294	C6H438	C6H4X3	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.956
HCDG_00119	HCDG_00951	C6H438	C6H2L9	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Polyubiquitin.	0.673
HCDG_00119	HCDG_01577	C6H438	C6H816	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Uncharacterized protein.	0.620
HCDG_00119	HCDG_02569	C6H438	C6H8N8	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.918
HCDG_00119	HCDG_03741	C6H438	C6HCJ2	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.955
HCDG_00119	HCDG_04539	C6H438	C6HF16	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Protein kinase.	0.410
HCDG_00119	HCDG_05398	C6H438	C6HG58	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Calcium channel subunit Mid1.	0.583
HCDG_00119	HCDG_07556	C6H438	C6HLT7	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Rac1 GTPase.	0.620
HCDG_00119	HCDG_08813	C6H438	C6HQZ1	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.853
HCDG_00119	HCDG_09033	C6H438	C6HS52	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	MAP kinase Hogp.	0.583
HCDG_00119	HCDG_09294	C6H438	C6HSW3	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.964
HCDG_00119	HCDG_09476	C6H438	C6HTE5	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.583
HCDG_00183	HCDG_01577	C6H4A2	C6H816	SRF-type transcription factor RlmA.	Uncharacterized protein.	0.638
HCDG_00183	HCDG_04539	C6H4A2	C6HF16	SRF-type transcription factor RlmA.	Protein kinase.	0.669
HCDG_00183	HCDG_05398	C6H4A2	C6HG58	SRF-type transcription factor RlmA.	Calcium channel subunit Mid1.	0.923
HCDG_00183	HCDG_07556	C6H4A2	C6HLT7	SRF-type transcription factor RlmA.	Rac1 GTPase.	0.638
HCDG_00183	HCDG_09033	C6H4A2	C6HS52	SRF-type transcription factor RlmA.	MAP kinase Hogp.	0.924
HCDG_00183	HCDG_09476	C6H4A2	C6HTE5	SRF-type transcription factor RlmA.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.924
HCDG_00294	HCDG_00119	C6H4X3	C6H438	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.956
HCDG_00294	HCDG_00951	C6H4X3	C6H2L9	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Polyubiquitin.	0.717