39 items (Histoplasma capsulatum H143) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HCDG_07151	Serine/threonine-protein phosphatase. (322 aa)
	HCDG_08381	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (541 aa)
	HCDG_08497	Uncharacterized protein. (387 aa)
	HCDG_07288	Asparaginyl-tRNA synthetase. (508 aa)
	HCDG_08001	Uncharacterized protein. (54 aa)
	HCDG_00573	PCRan1 kinase; Belongs to the protein kinase superfamily. (401 aa)
	HCDG_00642	Uncharacterized protein. (369 aa)
	HCDG_00951	Polyubiquitin. (305 aa)
	HCDG_00965	Uncharacterized protein. (459 aa)
	HCDG_01177	RECA_2 domain-containing protein. (423 aa)
	HCDG_00335	Topoisomerase I. (109 aa)
	HCDG_00336	Topoisomerase 1-associated factor 1. (810 aa)
	HCDG_00382	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (346 aa)
	HCDG_00385	Uncharacterized protein. (711 aa)
	HCDG_00386	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1490 aa)
	HCDG_01727	DNA polymerase delta subunit 4. (214 aa)
	HCDG_02051	Serine/threonine protein kinase. (390 aa)
	HCDG_02191	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (630 aa)
	HCDG_08112	Rad51 family DNA repair protein. (455 aa)
	HCDG_02221	Cytoplasm to vacuole targeting Vps64. (760 aa)
	HCDG_02449	Uncharacterized protein. (110 aa)
	HCDG_01500	BZIP domain-containing protein. (252 aa)
	HCDG_01592	RAD52 DNA repair protein RADC. (204 aa)
	HCDG_01593	RAD52 DNA repair protein RADC. (276 aa)
	HCDG_01632	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (572 aa)
	HCDG_02809	DNA repair protein RAD51. (249 aa)
	HCDG_03831	RecA family ATPase Rhp57. (701 aa)
	HCDG_03938	Uncharacterized protein. (772 aa)
	HCDG_03377	3'-5' exonuclease/helicase. (947 aa)
	HCDG_03585	Ubiquitin/79aa fusion protein. (152 aa)
	HCDG_03657	Crossover junction endonuclease mus81. (650 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (421 aa)
	HCDG_04600	ERCC4 domain-containing protein. (197 aa)
	HCDG_06388	RecQ family helicase MusN. (1559 aa)
	HCDG_06708	BRCT domain-containing protein. (891 aa)
	HCDG_06720	Uncharacterized protein. (452 aa)
	HCDG_06721	Uncharacterized protein. (685 aa)
	HCDG_06860	Serine/threonine protein phosphatase PP-X isozyme 1. (427 aa)
	HCDG_06884	Protein kinase. (713 aa)

Your Current Organism:

Histoplasma capsulatum H143

NCBI taxonomy Id: 544712
Other names: Ajellomyces capsulatus H143, H. capsulatum H143

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCDG_00335	HCDG_00336	C6H514	C6H515	Topoisomerase I.	Topoisomerase 1-associated factor 1.	0.922
HCDG_00335	HCDG_00382	C6H514	C6H561	Topoisomerase I.	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.981
HCDG_00335	HCDG_00385	C6H514	C6H564	Topoisomerase I.	Uncharacterized protein.	0.473
HCDG_00335	HCDG_00386	C6H514	C6H565	Topoisomerase I.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.473
HCDG_00335	HCDG_01632	C6H514	C6H871	Topoisomerase I.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.741
HCDG_00335	HCDG_02051	C6H514	C6H6K0	Topoisomerase I.	Serine/threonine protein kinase.	0.804
HCDG_00335	HCDG_02191	C6H514	C6H6Z0	Topoisomerase I.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.400
HCDG_00335	HCDG_02809	C6H514	C6H9C8	Topoisomerase I.	DNA repair protein RAD51.	0.421
HCDG_00335	HCDG_03657	C6H514	C6HCA8	Topoisomerase I.	Crossover junction endonuclease mus81.	0.548
HCDG_00335	HCDG_06388	C6H514	C6HJK7	Topoisomerase I.	RecQ family helicase MusN.	0.741
HCDG_00335	HCDG_06708	C6H514	C6HKH7	Topoisomerase I.	BRCT domain-containing protein.	0.546
HCDG_00335	HCDG_06884	C6H514	C6HL03	Topoisomerase I.	Protein kinase.	0.742
HCDG_00335	HCDG_08381	C6H514	C6HQA0	Topoisomerase I.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.923
HCDG_00336	HCDG_00335	C6H515	C6H514	Topoisomerase 1-associated factor 1.	Topoisomerase I.	0.922
HCDG_00336	HCDG_00382	C6H515	C6H561	Topoisomerase 1-associated factor 1.	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.981
HCDG_00336	HCDG_00385	C6H515	C6H564	Topoisomerase 1-associated factor 1.	Uncharacterized protein.	0.473
HCDG_00336	HCDG_00386	C6H515	C6H565	Topoisomerase 1-associated factor 1.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.473
HCDG_00336	HCDG_01632	C6H515	C6H871	Topoisomerase 1-associated factor 1.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.741
HCDG_00336	HCDG_02051	C6H515	C6H6K0	Topoisomerase 1-associated factor 1.	Serine/threonine protein kinase.	0.804
HCDG_00336	HCDG_02191	C6H515	C6H6Z0	Topoisomerase 1-associated factor 1.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.400