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AEF84402.1 AEF84402.1 pyk pyk AEF85323.1 AEF85323.1 AEF84822.1 AEF84822.1 ppk ppk AEF86769.1 AEF86769.1 hprK hprK AEF86290.1 AEF86290.1 adk adk AEF84704.1 AEF84704.1 ackA ackA AEF84124.1 AEF84124.1 ispE ispE AEF86047.1 AEF86047.1 AEF84417.1 AEF84417.1 AEF86893.1 AEF86893.1 AEF84425.1 AEF84425.1 pfp pfp AEF86672.1 AEF86672.1 AEF84044.1 AEF84044.1 AEF86803.1 AEF86803.1 AEF83526.1 AEF83526.1 AEF85951.1 AEF85951.1 AEF84516.1 AEF84516.1 AEF86141.1 AEF86141.1 AEF85340.1 AEF85340.1 AEF85263.1 AEF85263.1 AEF84858.1 AEF84858.1 AEF86215.1 AEF86215.1 AEF85996.1 AEF85996.1 ppdK ppdK AEF85960.1 AEF85960.1 cmk cmk AEF84934.1 AEF84934.1 cmk-2 cmk-2 pgk_1 pgk_1 AEF86267.1 AEF86267.1 AEF85241.1 AEF85241.1 xylB xylB AEF84336.1 AEF84336.1 tmk tmk AEF84196.1 AEF84196.1 AEF86574.1 AEF86574.1 ndk ndk AEF84522.1 AEF84522.1 AEF85223.1 AEF85223.1 AEF85803.1 AEF85803.1 AEF84322.1 AEF84322.1 AEF85454.1 AEF85454.1 nadK nadK ptsP_3 ptsP_3 AEF86532.1 AEF86532.1 ptsP_2 ptsP_2 pfkB pfkB AEF86080.1 AEF86080.1 AEF84490.1 AEF84490.1 AEF83621.1 AEF83621.1 AEF86927.1 AEF86927.1 AEF84400.1 AEF84400.1 selD selD coaE coaE AEF84829.1 AEF84829.1 ptsP_1 ptsP_1 AEF86456.1 AEF86456.1 AEF84654.1 AEF84654.1 glpK glpK argB argB AEF84218.1 AEF84218.1 AEF86045.1 AEF86045.1 AEF85767.1 AEF85767.1 pfkA-2 pfkA-2 AEF86314.1 AEF86314.1 AEF86375.1 AEF86375.1 AEF84477.1 AEF84477.1 AEF84431.1 AEF84431.1 AEF84335.1 AEF84335.1 AEF84644.1 AEF84644.1 AEF83861.1 AEF83861.1 AEF86011.1 AEF86011.1 AEF86486.1 AEF86486.1 pgk_2 pgk_2 ptsP_4 ptsP_4 AEF84993.1 AEF84993.1 AEF86207.1 AEF86207.1 AEF85545.1 AEF85545.1 AEF83886.1 AEF83886.1 AEF84697.1 AEF84697.1 proB proB aroK aroK cdsA_1 cdsA_1 AEF84945.1 AEF84945.1 AEF86967.1 AEF86967.1 pfkA pfkA ndk-2 ndk-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AEF84402.1PAS domain protein; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM PF08448; match to protein family HMM TIGR00229. (902 aa)
pykPyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (597 aa)
AEF85323.1Carbohydrate kinase, PfkB family; Identified by match to protein family HMM PF00294. (304 aa)
AEF84822.1Sugar kinase, fggy family; Identified by match to protein family HMM PF00370; match to protein family HMM PF02782. (507 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (733 aa)
AEF86769.1Histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. (598 aa)
hprKHPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). (335 aa)
AEF86290.1Conserved hypothetical protein. (194 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (211 aa)
AEF84704.1Sensory box histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. (1070 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (445 aa)
AEF84124.1Pasta domain protein; Identified by match to protein family HMM PF03793. (361 aa)
ispE4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (351 aa)
AEF86047.1Sensor histidine kinase with ATPase domain, two fused; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF01627; match to protein family HMM PF02518. (894 aa)
AEF84417.1Sensor protein GacS; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF01627; match to protein family HMM PF02518. (930 aa)
AEF86893.1Putative lipoprotein. (515 aa)
AEF84425.1Signal transduction histidine kinase; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM PF08447; match to protein family HMM PF08448; match to protein family HMM TIGR00229. (1252 aa)
pfpDiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (551 aa)
AEF86672.1Putative uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (227 aa)
AEF84044.1Signal transduction histidine kinase; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. (667 aa)
AEF86803.1Response regulator receiver domain protein; Identified by match to protein family HMM PF00072; match to protein family HMM PF01627; match to protein family HMM PF02518. (782 aa)
AEF83526.1Putative riboflavin biosynthesis protein RibF; Identified by match to protein family HMM PF01467; match to protein family HMM PF06574. (262 aa)
AEF85951.1Putative hydroxypyruvate reductase; Identified by match to protein family HMM PF05161. (415 aa)
AEF84516.1Pyruvate, phosphate dikinase (Pyruvate, orthophosphatedikinase); Identified by match to protein family HMM PF00391; match to protein family HMM PF02896. (585 aa)
AEF86141.1Conserved hypothetical protein. (439 aa)
AEF85340.1Putative signal transduction histidine kinase; Identified by match to protein family HMM PF02518. (402 aa)
AEF85263.1Putative ribokinase; Identified by match to protein family HMM PF00294. (297 aa)
AEF84858.1Putative pyrogenic exotoxin B; Identified by match to protein family HMM PF01640. (478 aa)
AEF86215.1Anti-sigma regulatory factor. (150 aa)
AEF85996.1Sensory box histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM TIGR00229. (406 aa)
ppdKPyruvate, phosphate dikinase; Identified by match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828. (1002 aa)
AEF85960.1Multi-sensor Hybrid Histidine Kinase; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518. (1054 aa)
cmkCytidylate kinase/ribosomal protein S1; Identified by match to protein family HMM PF00575; match to protein family HMM PF02224; match to protein family HMM TIGR00017; match to protein family HMM TIGR00717. (798 aa)
AEF84934.1D-glycero-D-manno-heptose 7-phosphate kinase; Identified by match to protein family HMM PF00288; match to protein family HMM PF08544. (344 aa)
cmk-2Putative cytidylate kinase; Identified by match to protein family HMM PF01202; match to protein family HMM TIGR02173. (177 aa)
pgk_1Phosphoglycerate kinase; Identified by match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (420 aa)
AEF86267.1RelA/SpoT domain protein; Identified by match to protein family HMM PF00515; match to protein family HMM PF04607; match to protein family HMM PF07719. (419 aa)
AEF85241.1Two-component system sensor kinase; Identified by match to protein family HMM PF02518. (248 aa)
xylBXylulokinase; Identified by match to protein family HMM PF00370; match to protein family HMM PF02782; match to protein family HMM TIGR01312. (496 aa)
AEF84336.1Pyridoxal kinase; Identified by match to protein family HMM TIGR00687; Belongs to the pyridoxine kinase family. (285 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (221 aa)
AEF84196.1Thiamine diphosphokinase; Identified by match to protein family HMM PF04263; match to protein family HMM TIGR01378. (215 aa)
AEF86574.1Two component sensor kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. (363 aa)
ndkNucleoside diphosphate kinase family; Identified by match to protein family HMM PF00334. (392 aa)
AEF84522.1Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657. (847 aa)
AEF85223.1Putative galactokinase (Galactose kinase); Identified by match to protein family HMM PF00288; match to protein family HMM PF08544; Belongs to the GHMP kinase family. (388 aa)
AEF85803.1MmoS; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF02743. (808 aa)
AEF84322.1Putative PE protein. (272 aa)
AEF85454.1PAS domain protein; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518. (976 aa)
nadKPutative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (297 aa)
ptsP_3Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (540 aa)
AEF86532.1PTS system beta-glucoside-specific EIIBCA component; Identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00830. (650 aa)
ptsP_2Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (539 aa)
pfkB1-phosphofructokinase; Identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168; Belongs to the carbohydrate kinase PfkB family. (324 aa)
AEF86080.1Chemotaxis protein CheA; Identified by match to protein family HMM PF01584; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM PF02895; match to protein family HMM PF07194. (787 aa)
AEF84490.1Lysine-sensitive aspartokinase 3 (Lysine-sensitiveaspartokinase III) (Aspartate kinase III); Identified by match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (451 aa)
AEF83621.1PfkB domain protein; Identified by match to protein family HMM PF00294. (367 aa)
AEF86927.1Conserved hypothetical protein. (233 aa)
AEF84400.1Putative histidine kinase internal region; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF06580. (513 aa)
selDSelenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (350 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (213 aa)
AEF84829.1Conserved hypothetical protein; Identified by match to protein family HMM PF02518. (395 aa)
ptsP_1Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (579 aa)
AEF86456.1Aminoglycoside phosphotransferase; Identified by match to protein family HMM PF01163; match to protein family HMM PF01636. (249 aa)
AEF84654.1RelA/SpoT domain protein; Identified by match to protein family HMM PF04607. (223 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (494 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (296 aa)
AEF84218.1Two-component system sensor kinase; Identified by match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF07730. (428 aa)
AEF86045.1Identified by match to protein family HMM PF00485. (569 aa)
AEF85767.1Multi-sensor signal transduction histidine kinase; Identified by match to protein family HMM PF02518; match to protein family HMM PF07730. (409 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (367 aa)
AEF86314.1Fructokinase; Identified by match to protein family HMM PF00294. (326 aa)
AEF86375.1Diacylglycerol kinase; Identified by match to protein family HMM PF00781. (374 aa)
AEF84477.1Carhohydrate kinase, fggy family; Identified by match to protein family HMM PF00370; match to protein family HMM PF02782. (491 aa)
AEF84431.1FGGY domain protein; Identified by match to protein family HMM PF00370; match to protein family HMM PF02782. (540 aa)
AEF84335.1MdsC protein. (376 aa)
AEF84644.1Hexokinase; Identified by match to protein family HMM PF00349; match to protein family HMM PF03727. (451 aa)
AEF83861.1Conserved domain protein. (69 aa)
AEF86011.1Putative signal transduction histidine kinase, nitrogen specific, NtrB; Identified by match to protein family HMM PF00512; match to protein family HMM PF02518. (449 aa)
AEF86486.1Multi-sensor hybrid histidine kinase; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM PF08448; match to protein family HMM TIGR00229. (556 aa)
pgk_2Phosphoglycerate kinase; Identified by match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (418 aa)
ptsP_4Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (537 aa)
AEF84993.1Cellobiose PTS system EIIB component; Identified by match to protein family HMM PF02302. (98 aa)
AEF86207.1Bifunctional adenosylcobalamin biosynthesis protein CobP; Identified by match to protein family HMM PF02283. (176 aa)
AEF85545.1Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. (468 aa)
AEF83886.1Khg/kdpg family aldolase/carbohydrate kinase, pfkb family; Identified by match to protein family HMM PF00294. (340 aa)
AEF84697.1Putative phospholipid-binding domain family protein; Identified by match to protein family HMM PF04972. (273 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (263 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (210 aa)
cdsA_1Phosphatidate cytidylyltransferase; Identified by match to protein family HMM PF01148. (216 aa)
AEF84945.1Galactokinase; Identified by match to protein family HMM PF00288; Belongs to the GHMP kinase family. (449 aa)
AEF86967.1Conserved hypothetical protein; Identified by match to protein family HMM PF00781; match to protein family HMM TIGR00147. (339 aa)
pfkADiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (452 aa)
ndk-2Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (147 aa)
Your Current Organism:
Treponema primitia ZAS2
NCBI taxonomy Id: 545694
Other names: T. primitia ZAS-2, Treponema primitia ZAS-2, Treponema primitia str. ZAS-2, Treponema primitia strain ZAS-2, Treponema sp. ZAS-2
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