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AEF81235.1 AEF81235.1 AEF81922.1 AEF81922.1 ilvE ilvE ilvN ilvN ilvC ilvC leuA leuA AEF80811.1 AEF80811.1 leuB leuB ilvD ilvD ilvB ilvB AEF81138.1 AEF81138.1 AEF80868.1 AEF80868.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AEF81235.13-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Identified by match to protein family HMM PF00694; Belongs to the LeuD family. (174 aa)
AEF81922.13-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330; match to protein family HMM TIGR01343; match to protein family HMM TIGR02086; Belongs to the aconitase/IPM isomerase family. (427 aa)
ilvEBranched-chain-amino-acid transaminase; Identified by match to protein family HMM PF01063; match to protein family HMM TIGR01123; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (362 aa)
ilvNAcetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. (176 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (512 aa)
AEF80811.12-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM PF08502; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. (533 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (383 aa)
ilvDDihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. (552 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. (583 aa)
AEF81138.12-isopropylmalate synthase (Alpha-isopropylmalatesynthase) (Alpha-IPM synthetase); Identified by match to protein family HMM PF00682; Belongs to the alpha-IPM synthase/homocitrate synthase family. (521 aa)
AEF80868.1Aspartate aminotransferase; Identified by match to protein family HMM PF00155. (405 aa)
Your Current Organism:
Treponema azotonutricium
NCBI taxonomy Id: 545695
Other names: T. azotonutricium ZAS-9, Treponema azotonutricium ZAS-9, Treponema azotonutricium str. ZAS-9, Treponema azotonutricium strain ZAS-9, Treponema sp. ZAS-9
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