STRINGSTRING
AEF81798.1 AEF81798.1 pckG pckG AEF81300.1 AEF81300.1 dapA dapA rlpA rlpA AEF80692.1 AEF80692.1 AEF81669.1 AEF81669.1 AEF82996.1 AEF82996.1 AEF81530.1 AEF81530.1 AEF82418.1 AEF82418.1 AEF81321.1 AEF81321.1 AEF82667.1 AEF82667.1 AEF81003.1 AEF81003.1 AEF83121.1 AEF83121.1 AEF82644.1 AEF82644.1 AEF80392.1 AEF80392.1 AEF83137.1 AEF83137.1 AEF83145.1 AEF83145.1 AEF81346.1 AEF81346.1 AEF81531.1 AEF81531.1 AEF80564.1 AEF80564.1 AEF83390.1 AEF83390.1 ltaE ltaE AEF82268.1 AEF82268.1 AEF80739.1 AEF80739.1 AEF81492.1 AEF81492.1 AEF82068.1 AEF82068.1 AEF82228.1 AEF82228.1 AEF80283.1 AEF80283.1 AEF80680.1 AEF80680.1 AEF81946.1 AEF81946.1 AEF83099.1 AEF83099.1 AEF80729.1 AEF80729.1 AEF81235.1 AEF81235.1 AEF81922.1 AEF81922.1 AEF80776.1 AEF80776.1 pyrF pyrF aepY aepY AEF82083.1 AEF82083.1 AEF80899.1 AEF80899.1 AEF81077.1 AEF81077.1 AEF80117.1 AEF80117.1 AEF80573.1 AEF80573.1 luxS luxS thrC_2 thrC_2 purE purE AEF80470.1 AEF80470.1 AEF80343.1 AEF80343.1 AEF82167.1 AEF82167.1 thrC_1 thrC_1 AEF82941.1 AEF82941.1 AEF81038.1 AEF81038.1 AEF83204.1 AEF83204.1 fba fba AEF82449.1 AEF82449.1 AEF80378.1 AEF80378.1 AEF80941.1 AEF80941.1 AEF82566.1 AEF82566.1 AEF81297.1 AEF81297.1 aroB aroB nnrD nnrD AEF81185.1 AEF81185.1 AEF83449.1 AEF83449.1 AEF81749.1 AEF81749.1 mltG mltG AEF82791.1 AEF82791.1 AEF81763.1 AEF81763.1 AEF81250.1 AEF81250.1 dacA dacA AEF83141.1 AEF83141.1 AEF81704.1 AEF81704.1 aroF aroF AEF80487.1 AEF80487.1 oadA oadA AEF80682.1 AEF80682.1 AEF82050.1 AEF82050.1 AEF81295.1 AEF81295.1 AEF80186.1 AEF80186.1 eno eno ubiD ubiD AEF80288.1 AEF80288.1 AEF83350.1 AEF83350.1 AEF82039.1 AEF82039.1 AEF83259.1 AEF83259.1 pheA pheA deoC_2 deoC_2 ilvD ilvD AEF82966.1 AEF82966.1 rfbB rfbB aroC aroC ispF ispF AEF82183.1 AEF82183.1 AEF81772.1 AEF81772.1 AEF80707.1 AEF80707.1 hisB hisB hisH hisH hisF hisF deoC_1 deoC_1 AEF83472.1 AEF83472.1 sdaAA sdaAA sdaAB sdaAB argH argH AEF80445.1 AEF80445.1 AEF81977.1 AEF81977.1 AEF81374.1 AEF81374.1 AEF82856.1 AEF82856.1 AEF81299.1 AEF81299.1 AEF80918.1 AEF80918.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AEF81798.1Cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. (386 aa)
pckGPhosphoenolpyruvate carboxykinase (ATP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (611 aa)
AEF81300.1Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF02784. (424 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa)
rlpARare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (260 aa)
AEF80692.1Fructose-6-phosphate aldolase 2; Identified by match to protein family HMM PF00923. (250 aa)
AEF81669.1Conserved hypothetical protein. (200 aa)
AEF82996.1Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Identified by match to protein family HMM PF07977. (142 aa)
AEF81530.1Hypothetical protein; Identified by glimmer; putative; Belongs to the uroporphyrinogen decarboxylase family. (332 aa)
AEF82418.1Putative adenylate cyclase; Identified by match to protein family HMM PF00211; match to protein family HMM PF00672. (627 aa)
AEF81321.1Putative adenylyl cyclase CyaB; Identified by match to protein family HMM PF01928; match to protein family HMM TIGR00318. (192 aa)
AEF82667.1Hypothetical protein; Identified by glimmer; putative; Belongs to the uroporphyrinogen decarboxylase family. (345 aa)
AEF81003.1Putative methylcobalamin:Coenzyme M methyltransferase; Belongs to the uroporphyrinogen decarboxylase family. (279 aa)
AEF83121.1Methyltransferase MtaA/CmuA family; Identified by match to protein family HMM PF01208; Belongs to the uroporphyrinogen decarboxylase family. (344 aa)
AEF82644.1[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase; Identified by match to protein family HMM PF01208; Belongs to the uroporphyrinogen decarboxylase family. (347 aa)
AEF80392.1O-acetylhomoserine (thiol)-lyase; Identified by match to protein family HMM PF00155; match to protein family HMM PF01053; match to protein family HMM PF01212. (436 aa)
AEF83137.1Hypothetical protein; Identified by glimmer; putative; Belongs to the uroporphyrinogen decarboxylase family. (376 aa)
AEF83145.1Oxaloacetate decarboxylase, gamma subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the OadG family. (87 aa)
AEF81346.1Conserved hypothetical protein. (123 aa)
AEF81531.1Conserved hypothetical protein; Identified by match to protein family HMM PF09674; match to protein family HMM TIGR02757. (230 aa)
AEF80564.1Putative adenylosuccinate lyase; Identified by match to protein family HMM PF00206. (488 aa)
AEF83390.1Methionine gamma-lyase (L-methioninase); Identified by match to protein family HMM PF01053. (409 aa)
ltaELow-specificity L-threonine aldolase; Identified by match to protein family HMM PF01212. (349 aa)
AEF82268.1Conserved hypothetical protein; Belongs to the uroporphyrinogen decarboxylase family. (354 aa)
AEF80739.1Hypothetical protein; Identified by glimmer; putative; Belongs to the uroporphyrinogen decarboxylase family. (404 aa)
AEF81492.1Siroheme synthase; Identified by match to protein family HMM TIGR01470. (193 aa)
AEF82068.1uroporphyrinogen-III synthase/methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01469. (511 aa)
AEF82228.1Khg/kdpg aldolase; Identified by match to protein family HMM PF01081; match to protein family HMM TIGR01182. (219 aa)
AEF80283.1L-ribulose-5-phosphate 4-epimerase; Identified by match to protein family HMM PF00596. (244 aa)
AEF80680.1Oxaloacetate decarboxylase beta chain; Identified by match to protein family HMM PF03977; match to protein family HMM TIGR01109. (379 aa)
AEF81946.1Uroporphyrinogen decarboxylase (URO-D) superfamily; Identified by match to protein family HMM PF01208; Belongs to the uroporphyrinogen decarboxylase family. (333 aa)
AEF83099.1Phosphatidylserine decarboxylase-like protein; Identified by match to protein family HMM PF02666; match to protein family HMM TIGR00164. (213 aa)
AEF80729.1Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (462 aa)
AEF81235.13-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Identified by match to protein family HMM PF00694; Belongs to the LeuD family. (174 aa)
AEF81922.13-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330; match to protein family HMM TIGR01343; match to protein family HMM TIGR02086; Belongs to the aconitase/IPM isomerase family. (427 aa)
AEF80776.1Putative methyltransferase; Belongs to the uroporphyrinogen decarboxylase family. (414 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Identified by match to protein family HMM PF00215; match to protein family HMM TIGR02127; Belongs to the OMP decarboxylase family. Type 2 subfamily. (293 aa)
aepYPhosphonopyruvate decarboxylase; Identified by match to protein family HMM PF02775; match to protein family HMM TIGR03297. (394 aa)
AEF82083.1Phosphoenolpyruvate mutase; Identified by match to protein family HMM PF01467; match to protein family HMM TIGR00125; match to protein family HMM TIGR02320. (432 aa)
AEF80899.1Hypothetical protein; Identified by glimmer; putative; Belongs to the uroporphyrinogen decarboxylase family. (353 aa)
AEF81077.1Methyltransferase MtaA/CmuA; Identified by match to protein family HMM PF01208; Belongs to the uroporphyrinogen decarboxylase family. (344 aa)
AEF80117.1Methyltransferase MtaA/CmuA; Identified by match to protein family HMM PF01208; Belongs to the uroporphyrinogen decarboxylase family. (346 aa)
AEF80573.1Uroporphyrinogen decarboxylase (URO-D) superfamily; Identified by match to protein family HMM PF01208; Belongs to the uroporphyrinogen decarboxylase family. (342 aa)
luxSS-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (158 aa)
thrC_2Threonine synthase; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR00260. (434 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa)
AEF80470.1Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (81 aa)
AEF80343.1Conserved hypothetical protein; Belongs to the uroporphyrinogen decarboxylase family. (377 aa)
AEF82167.1Decarboxylase, pyridoxal-dependent family; Identified by match to protein family HMM PF00278; match to protein family HMM PF02784; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (390 aa)
thrC_1Threonine synthase; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR00260. (441 aa)
AEF82941.1Malate dehydrogenase (oxaloacetate-decarboxylating); Identified by match to protein family HMM PF00390; match to protein family HMM PF03949. (484 aa)
AEF81038.1Sodium pump decarboxylase, gamma subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the OadG family. (84 aa)
AEF83204.1Oxaloacetate decarboxylase, subunit beta; Identified by match to protein family HMM PF03977; match to protein family HMM TIGR01109. (468 aa)
fbaFructose-1,6-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; match to protein family HMM TIGR01859. (332 aa)
AEF82449.1Identified by match to protein family HMM PF00330; match to protein family HMM PF00694. (776 aa)
AEF80378.1Conserved hypothetical protein. (823 aa)
AEF80941.1Hypothetical protein; Identified by glimmer; putative; Belongs to the uroporphyrinogen decarboxylase family. (342 aa)
AEF82566.1YcsI; Identified by match to protein family HMM PF07286; Belongs to the D-glutamate cyclase family. (261 aa)
AEF81297.1Cystathionine gamma-lyase; Identified by match to protein family HMM PF01053. (399 aa)
aroB3-dehydroquinate synthase; Identified by match to protein family HMM PF01761. (362 aa)
nnrDCarbohydrate kinase family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family. (531 aa)
AEF81185.1Conserved hypothetical protein. (510 aa)
AEF83449.1Hypothetical protein; Identified by glimmer; putative. (535 aa)
AEF81749.1Conserved hypothetical protein; Identified by match to protein family HMM PF03130. (499 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (358 aa)
AEF82791.1Hypothetical protein; Identified by glimmer; putative; Belongs to the uroporphyrinogen decarboxylase family. (333 aa)
AEF81763.1Adenylate/guanylate cyclase; Identified by match to protein family HMM PF00211. (325 aa)
AEF81250.1Probable fructose-bisphosphate aldolase 1; Identified by match to protein family HMM PF01116. (301 aa)
dacAConserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (282 aa)
AEF83141.1Fumarate hydratase; Identified by match to protein family HMM PF05681; match to protein family HMM PF05683; match to protein family HMM TIGR00723. (548 aa)
AEF81704.16-pyruvoyl tetrahydrobiopterin synthase (ptps) (ptpsynthase); Identified by match to protein family HMM PF01242. (124 aa)
aroF3-deoxy-7-phosphoheptulonate synthase; Identified by match to protein family HMM PF00793; match to protein family HMM TIGR01361. (341 aa)
AEF80487.1Conserved hypothetical protein; Belongs to the uroporphyrinogen decarboxylase family. (364 aa)
oadAOxaloacetate decarboxylase alpha subunit; Identified by match to protein family HMM PF00364; match to protein family HMM PF00682; match to protein family HMM PF02436; match to protein family HMM TIGR01108. (681 aa)
AEF80682.1Hypothetical protein; Identified by glimmer; putative; Belongs to the uroporphyrinogen decarboxylase family. (339 aa)
AEF82050.1Hypothetical protein; Identified by glimmer; putative; Belongs to the uroporphyrinogen decarboxylase family. (320 aa)
AEF81295.1Conserved hypothetical protein; Belongs to the uroporphyrinogen decarboxylase family. (341 aa)
AEF80186.1Conserved hypothetical protein; Belongs to the uroporphyrinogen decarboxylase family. (339 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
ubiD3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148; Belongs to the UbiD family. (484 aa)
AEF80288.1Aspartate ammonia-lyase (Aspartase); Identified by match to protein family HMM PF00206. (439 aa)
AEF83350.1O-acetylhomoserine (thiol)-lyase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. (427 aa)
AEF82039.1Amidohydrolase 2; Identified by match to protein family HMM PF04909. (259 aa)
AEF83259.1Conserved hypothetical protein; Identified by match to protein family HMM PF01969; match to protein family HMM TIGR00299; Belongs to the LarC family. (408 aa)
pheA3-deoxy-7-phosphoheptulonate synthase; Identified by match to protein family HMM PF00793; match to protein family HMM PF00800; match to protein family HMM PF01842; match to protein family HMM TIGR01361. (663 aa)
deoC_2Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (234 aa)
ilvDDihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. (552 aa)
AEF82966.1Identified by match to protein family HMM PF04892. (137 aa)
rfbBdTDP-glucose 4,6-dehydratase; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (372 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (370 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa)
AEF82183.1Endonuclease III (DNA-(apurinic or apyrimidinic site)lyase); Identified by match to protein family HMM PF00633; match to protein family HMM PF00730. (247 aa)
AEF81772.1O-acetylhomoserine (thiol)-lyase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01053; match to protein family HMM TIGR01326. (712 aa)
AEF80707.1Cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. (382 aa)
hisBImidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. (189 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (206 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa)
deoC_1Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (215 aa)
AEF83472.1Hypothetical protein; Identified by glimmer; putative. (502 aa)
sdaAAL-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718. (314 aa)
sdaABL-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719. (237 aa)
argHArgininosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00838. (470 aa)
AEF80445.1Conserved hypothetical protein; Belongs to the uroporphyrinogen decarboxylase family. (372 aa)
AEF81977.1Cobalamin B12-binding protein; Belongs to the uroporphyrinogen decarboxylase family. (68 aa)
AEF81374.1Putative methyltransferase CmuC. (325 aa)
AEF82856.1Hypothetical protein; Identified by glimmer; putative; Belongs to the uroporphyrinogen decarboxylase family. (385 aa)
AEF81299.1Putative methyltransferase CmuC; Belongs to the uroporphyrinogen decarboxylase family. (352 aa)
AEF80918.1Thiamine pyrophosphate enzyme; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. (553 aa)
Your Current Organism:
Treponema azotonutricium
NCBI taxonomy Id: 545695
Other names: T. azotonutricium ZAS-9, Treponema azotonutricium ZAS-9, Treponema azotonutricium str. ZAS-9, Treponema azotonutricium strain ZAS-9, Treponema sp. ZAS-9
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