STRINGSTRING
gnd gnd AEF80670.1 AEF80670.1 AEF82083.1 AEF82083.1 uxaC uxaC AEF82945.1 AEF82945.1 AEF80482.1 AEF80482.1 panE panE AEF81371.1 AEF81371.1 eno eno AEF80880.1 AEF80880.1 AEF81195.1 AEF81195.1 AEF83018.1 AEF83018.1 AEF82896.1 AEF82896.1 AEF80497.1 AEF80497.1 AEF81397.1 AEF81397.1 ispF ispF AEF80561.1 AEF80561.1 AEF82669.1 AEF82669.1 acpP acpP ispH ispH gap gap pgk pgk pfkA-2 pfkA-2 ispE ispE pyk pyk AEF80918.1 AEF80918.1 ispG ispG acpS acpS AEF81250.1 AEF81250.1 ppdK ppdK dxr dxr pfp pfp fba fba lipA lipA pgi pgi AEF81404.1 AEF81404.1 AEF80142.1 AEF80142.1 gpmI gpmI AEF82900.1 AEF82900.1 AEF80993.1 AEF80993.1 AEF81261.1 AEF81261.1 fabH fabH fabD fabD fabF fabF AEF82996.1 AEF82996.1 fabV fabV accB accB accD accD accA accA AEF82098.1 AEF82098.1 pfkA pfkA AEF83090.1 AEF83090.1 AEF80429.1 AEF80429.1 AEF81961.1 AEF81961.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
AEF80670.1Hypothetical protein; Identified by glimmer; putative. (430 aa)
AEF82083.1Phosphoenolpyruvate mutase; Identified by match to protein family HMM PF01467; match to protein family HMM TIGR00125; match to protein family HMM TIGR02320. (432 aa)
uxaCGlucuronate isomerase; Identified by match to protein family HMM PF02614. (479 aa)
AEF82945.1Acyl-coenzyme A synthetase ACSM3; Identified by match to protein family HMM PF00501. (564 aa)
AEF80482.1Amidohydrolase 3; Identified by match to protein family HMM PF07969. (548 aa)
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa)
AEF81371.1Amidohydrolase 2; Identified by match to protein family HMM PF04909. (284 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
AEF80880.1Radical SAM; Identified by match to protein family HMM PF04055. (340 aa)
AEF81195.1Conserved domain protein. (78 aa)
AEF83018.1AMP-dependent synthetase and ligase; Identified by match to protein family HMM PF00501. (577 aa)
AEF82896.1Putative long-chain-fatty-acid--CoA ligase; Identified by match to protein family HMM PF00501. (526 aa)
AEF80497.1Putative 3-dehydroquinate dehydratase, type 1/shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01487; match to protein family HMM PF01488; match to protein family HMM PF08501. (504 aa)
AEF81397.1Acyl-coenzyme A synthetase ACSM3; Identified by match to protein family HMM PF00501. (599 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa)
AEF80561.1Conserved hypothetical protein; Identified by match to protein family HMM PF01128; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (248 aa)
AEF82669.1AMP-dependent synthetase and ligase; Identified by match to protein family HMM PF00501. (570 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (310 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase, type I; Identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (357 aa)
pgkBifunctional PGK/TIM; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (668 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (368 aa)
ispE4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (311 aa)
pykPyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (611 aa)
AEF80918.1Thiamine pyrophosphate enzyme; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. (553 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (369 aa)
acpSHolo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa)
AEF81250.1Probable fructose-bisphosphate aldolase 1; Identified by match to protein family HMM PF01116. (301 aa)
ppdKPyruvate, phosphate dikinase; Identified by match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828. (966 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (381 aa)
pfpDiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (551 aa)
fbaFructose-1,6-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; match to protein family HMM TIGR01859. (332 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (282 aa)
pgiGlucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family. (529 aa)
AEF81404.1Identified by match to protein family HMM PF00753. (205 aa)
AEF80142.1Isocitrate dehydrogenase, NADP-dependent; Identified by match to protein family HMM PF00180; match to protein family HMM TIGR00127; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (402 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (560 aa)
AEF82900.1Metal-dependent hydrolase; Identified by match to protein family HMM PF00753. (285 aa)
AEF80993.1Hexokinase; Identified by match to protein family HMM PF00349; match to protein family HMM PF03727. (450 aa)
AEF81261.1Identified by match to protein family HMM PF01071; match to protein family HMM PF02222; match to protein family HMM PF02655. (519 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase III protein 1; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (341 aa)
fabD[acyl-carrier-protein] S-malonyltransferase; Identified by match to protein family HMM PF00698. (321 aa)
fabF3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (426 aa)
AEF82996.1Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Identified by match to protein family HMM PF07977. (142 aa)
fabVtrans-2-enoyl-CoA reductase; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA); Belongs to the TER reductase family. (422 aa)
accBacetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (152 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (259 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (306 aa)
AEF82098.1Radical SAM domain protein; Identified by match to protein family HMM PF04055. (406 aa)
pfkADiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (447 aa)
AEF83090.1long-chain-fatty-acid--CoA ligase; Identified by match to protein family HMM PF00501. (644 aa)
AEF80429.1Putative acyl-ACP thioesterase; Identified by match to protein family HMM PF01643. (289 aa)
AEF81961.1Putative metallo-beta-lactamase domain protein; Identified by match to protein family HMM PF00753. (193 aa)
Your Current Organism:
Treponema azotonutricium
NCBI taxonomy Id: 545695
Other names: T. azotonutricium ZAS-9, Treponema azotonutricium ZAS-9, Treponema azotonutricium str. ZAS-9, Treponema azotonutricium strain ZAS-9, Treponema sp. ZAS-9
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.