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| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (511 aa) |
| | AEF82634.1 | MdsC protein; Identified by match to protein family HMM PF01636. (376 aa) |
| | AEF82350.1 | Serine O-acetyltransferase; Identified by match to protein family HMM PF00132. (296 aa) |
| | thrH | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR02137. (201 aa) |
| | serS | serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa) |
| | AEF83301.1 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446. (287 aa) |
| | folP | Dihydropteroate synthase; Identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496. (280 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa) |
| | AEF80339.1 | Alginate O-acetylation protein; Identified by match to protein family HMM PF03062; Belongs to the membrane-bound acyltransferase family. (481 aa) |
| | AEF83029.1 | Conserved hypothetical protein. (274 aa) |
| | aroH | Chorismate mutase; Identified by match to protein family HMM PF07736; match to protein family HMM TIGR01796. (122 aa) |
| | AEF81748.1 | Putative mobilization protein; Identified by match to protein family HMM PF01076. (360 aa) |
| | AEF83306.1 | Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657. (832 aa) |
| | AEF81802.1 | Identified by match to protein family HMM PF00753. (313 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Identified by match to protein family HMM PF01288; match to protein family HMM TIGR01498. (163 aa) |
| | aroB | 3-dehydroquinate synthase; Identified by match to protein family HMM PF01761. (362 aa) |
| | AEF81959.1 | UDP-glucose 6-dehydrogenase; Identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026. (443 aa) |
| | AEF81300.1 | Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF02784. (424 aa) |
| | AEF82240.1 | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily. (401 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (365 aa) |
| | AEF81056.1 | Succinyl-diaminopimelate desuccinylase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01910. (407 aa) |
| | AEF82256.1 | Alcohol dehydrogenase [NADP+] (aldehyde reductase) (aldo-keto reductase family 1 member a1); Identified by match to protein family HMM PF00248. (337 aa) |
| | AEF83255.1 | Identified by match to protein family HMM PF00753. (296 aa) |
| | AEF80331.1 | Ferredoxin; Identified by match to protein family HMM PF00111. (539 aa) |
| | cysK_2 | Cysteine synthase A; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. (316 aa) |
| | AEF80982.1 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. (306 aa) |
| | AEF80392.1 | O-acetylhomoserine (thiol)-lyase; Identified by match to protein family HMM PF00155; match to protein family HMM PF01053; match to protein family HMM PF01212. (436 aa) |
| | AEF80549.1 | Glutamate synthase [NADPH] large chain (nadph-gogat); Identified by match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. (1569 aa) |
| | cysK_1 | Cysteine synthase A; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139. (325 aa) |
| | AEF80275.1 | Serine O-acetyltransferase; Identified by match to protein family HMM PF00132. (317 aa) |
| | AEF83471.1 | Cysteine synthase B (O-acetylserine sulfhydrylase B) (O-acetylserine (Thiol)-lyase B) (CSase B); Identified by match to protein family HMM PF00291. (297 aa) |
| | AEF81999.1 | Beta-lactamase domain protein; Identified by match to protein family HMM PF00753. (303 aa) |
| | AEF83447.1 | Dihydropteroate synthase DhpS; Identified by match to protein family HMM PF00809. (261 aa) |
| | AEF80643.1 | Methyl corrinoid protein; Identified by match to protein family HMM PF00809. (268 aa) |
| | AEF80215.1 | Ferredoxin; Identified by match to protein family HMM PF00111. (662 aa) |
| | AEF82476.1 | Ferredoxin; Identified by match to protein family HMM PF00111. (496 aa) |
| | AEF82098.1 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. (406 aa) |
| | AEF80429.1 | Putative acyl-ACP thioesterase; Identified by match to protein family HMM PF01643. (289 aa) |
| | AEF80729.1 | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (462 aa) |
| | AEF81235.1 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Identified by match to protein family HMM PF00694; Belongs to the LeuD family. (174 aa) |
| | AEF81922.1 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330; match to protein family HMM TIGR01343; match to protein family HMM TIGR02086; Belongs to the aconitase/IPM isomerase family. (427 aa) |
| | AEF80670.1 | Hypothetical protein; Identified by glimmer; putative. (430 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (187 aa) |
| | mtnN | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (236 aa) |
| | AEF81863.1 | Methionine synthase; Identified by match to protein family HMM PF02574. (430 aa) |
| | thrC_2 | Threonine synthase; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR00260. (434 aa) |
| | AEF82564.1 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. (328 aa) |
| | AEF82167.1 | Decarboxylase, pyridoxal-dependent family; Identified by match to protein family HMM PF00278; match to protein family HMM PF02784; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (390 aa) |
| | thrC_1 | Threonine synthase; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR00260. (441 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (286 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (263 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa) |
| | AEF81237.1 | Putative radical SAM domain protein; Identified by match to protein family HMM PF04055. (308 aa) |
| | panE | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa) |
| | serC | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (367 aa) |
| | AEF80880.1 | Radical SAM; Identified by match to protein family HMM PF04055. (340 aa) |
| | AEF83350.1 | O-acetylhomoserine (thiol)-lyase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. (427 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (306 aa) |
| | ilvE | Branched-chain-amino-acid transaminase; Identified by match to protein family HMM PF01063; match to protein family HMM TIGR01123; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (362 aa) |
| | ilvN | Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. (176 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (512 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (383 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. (552 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (370 aa) |
| | AEF80497.1 | Putative 3-dehydroquinate dehydratase, type 1/shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01487; match to protein family HMM PF01488; match to protein family HMM PF08501. (504 aa) |
| | AEF81772.1 | O-acetylhomoserine (thiol)-lyase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01053; match to protein family HMM TIGR01326. (712 aa) |
| | AEF80185.1 | Thermostable carboxypeptidase 1; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891. (379 aa) |
| | AEF81138.1 | 2-isopropylmalate synthase (Alpha-isopropylmalatesynthase) (Alpha-IPM synthetase); Identified by match to protein family HMM PF00682; Belongs to the alpha-IPM synthase/homocitrate synthase family. (521 aa) |
| | AEF81412.1 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). (284 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. (189 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (206 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | AEF83020.1 | Putative imidazole glycerol phosphate synthase subunit HisF; Identified by match to protein family HMM PF00977; match to protein family HMM PF01502; match to protein family HMM PF01503; match to protein family HMM TIGR03188; Belongs to the HisA/HisF family. (438 aa) |
| | AEF81356.1 | Histidinol-phosphate transaminase; Identified by match to protein family HMM PF00155. (326 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (442 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (381 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa) |
| | AEF82109.1 | Acetylornithine transaminase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00707. (400 aa) |
| | argG | Argininosuccinate synthase; Identified by match to protein family HMM PF00764; match to protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (422 aa) |
| | argH | Argininosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00838. (470 aa) |
| | cysK_3 | Cysteine synthase A; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139. (306 aa) |
| | AEF82067.1 | D-amino-acid transaminase; Identified by match to protein family HMM PF01063. (282 aa) |
| | AEF83482.1 | Acetylornithine deacetylase (Acetylornithinase) (AO) (N-acetylornithinase) (NAO); Identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01910. (380 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (282 aa) |
| | argR | Transcriptional regulator; Regulates arginine biosynthesis genes. (157 aa) |
| | AEF81683.1 | Morphine 6-dehydrogenase; Identified by match to protein family HMM PF00248. (288 aa) |
| | AEF81112.1 | AlgI; Identified by match to protein family HMM PF03062; Belongs to the membrane-bound acyltransferase family. (480 aa) |
| | AEF81261.1 | Identified by match to protein family HMM PF01071; match to protein family HMM PF02222; match to protein family HMM PF02655. (519 aa) |
| | AEF82103.1 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. (530 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase III protein 1; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (341 aa) |
| | fabD | [acyl-carrier-protein] S-malonyltransferase; Identified by match to protein family HMM PF00698. (321 aa) |
| | fabF | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (426 aa) |
| | AEF82996.1 | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Identified by match to protein family HMM PF07977. (142 aa) |
| | fabV | trans-2-enoyl-CoA reductase; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA); Belongs to the TER reductase family. (422 aa) |
| | accB | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (152 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (259 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (306 aa) |
| | mtnA | S-methyl-5-thioribose-1-phosphate isomerase; Identified by match to protein family HMM PF01008; match to protein family HMM TIGR00512; match to protein family HMM TIGR00524; Belongs to the eIF-2B alpha/beta/delta subunits family. (372 aa) |
| | mtnP | Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (248 aa) |
| | AEF80598.1 | Conserved hypothetical protein. (266 aa) |
| | AEF82415.1 | Lysine-sensitive aspartokinase 3 (Lysine-sensitiveaspartokinase III) (Aspartate kinase III); Identified by match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (446 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (261 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Identified by match to protein family HMM PF01118; match to protein family HMM PF02774; match to protein family HMM TIGR00978; Belongs to the aspartate-semialdehyde dehydrogenase family. (366 aa) |
