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| | AEF82350.1 | Serine O-acetyltransferase; Identified by match to protein family HMM PF00132. (296 aa) |
| | thrH | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR02137. (201 aa) |
| | aroF | 3-deoxy-7-phosphoheptulonate synthase; Identified by match to protein family HMM PF00793; match to protein family HMM TIGR01361. (341 aa) |
| | AEF83301.1 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446. (287 aa) |
| | rpiB_1 | Ribose-5-phosphate isomerase B; Identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689; match to protein family HMM TIGR01120. (152 aa) |
| | AEF81250.1 | Probable fructose-bisphosphate aldolase 1; Identified by match to protein family HMM PF01116. (301 aa) |
| | aroH | Chorismate mutase; Identified by match to protein family HMM PF07736; match to protein family HMM TIGR01796. (122 aa) |
| | AEF83306.1 | Bifunctional aspartokinase/homoserine dehydrogenase I; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657. (832 aa) |
| | AEF82929.1 | Aspartate aminotransferase; Identified by match to protein family HMM PF00155. (403 aa) |
| | AEF81574.1 | Ribose-phosphate pyrophosphokinase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01251; Belongs to the ribose-phosphate pyrophosphokinase family. (366 aa) |
| | rpe_1 | Ribulose-phosphate 3-epimerase; Identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa) |
| | AEF83449.1 | Hypothetical protein; Identified by glimmer; putative. (535 aa) |
| | aroB | 3-dehydroquinate synthase; Identified by match to protein family HMM PF01761. (362 aa) |
| | AEF81540.1 | Acetyltransferase, GNAT family; Identified by match to protein family HMM PF00583. (143 aa) |
| | AEF82449.1 | Identified by match to protein family HMM PF00330; match to protein family HMM PF00694. (776 aa) |
| | AEF82045.1 | Phosphoribosylpyrophosphate synthetase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01251; Belongs to the ribose-phosphate pyrophosphokinase family. (392 aa) |
| | fba | Fructose-1,6-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; match to protein family HMM TIGR01859. (332 aa) |
| | AEF80142.1 | Isocitrate dehydrogenase, NADP-dependent; Identified by match to protein family HMM PF00180; match to protein family HMM TIGR00127; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (402 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (560 aa) |
| | AEF82415.1 | Lysine-sensitive aspartokinase 3 (Lysine-sensitiveaspartokinase III) (Aspartate kinase III); Identified by match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (446 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (261 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Identified by match to protein family HMM PF01118; match to protein family HMM PF02774; match to protein family HMM TIGR00978; Belongs to the aspartate-semialdehyde dehydrogenase family. (366 aa) |
| | AEF81300.1 | Diaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF02784. (424 aa) |
| | AEF82240.1 | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily. (401 aa) |
| | AEF81798.1 | Cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. (386 aa) |
| | AEF81297.1 | Cystathionine gamma-lyase; Identified by match to protein family HMM PF01053. (399 aa) |
| | AEF81056.1 | Succinyl-diaminopimelate desuccinylase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01910. (407 aa) |
| | cysK_2 | Cysteine synthase A; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. (316 aa) |
| | AEF83078.1 | Glutamate synthase [NADPH] small chain (nadph-gogat); Identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01317. (484 aa) |
| | AEF80549.1 | Glutamate synthase [NADPH] large chain (nadph-gogat); Identified by match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. (1569 aa) |
| | cysK_1 | Cysteine synthase A; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139. (325 aa) |
| | AEF83390.1 | Methionine gamma-lyase (L-methioninase); Identified by match to protein family HMM PF01053. (409 aa) |
| | AEF80275.1 | Serine O-acetyltransferase; Identified by match to protein family HMM PF00132. (317 aa) |
| | AEF83471.1 | Cysteine synthase B (O-acetylserine sulfhydrylase B) (O-acetylserine (Thiol)-lyase B) (CSase B); Identified by match to protein family HMM PF00291. (297 aa) |
| | ltaE | Low-specificity L-threonine aldolase; Identified by match to protein family HMM PF01212. (349 aa) |
| | metK_2 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (391 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (656 aa) |
| | pfkA | Diphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (447 aa) |
| | AEF81856.1 | 3-hexulose-6-phosphate isomerase (6-phospho-3-hexuloisomerase) (PHI); Identified by match to protein family HMM PF01380. (189 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (511 aa) |
| | AEF80729.1 | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (462 aa) |
| | AEF81235.1 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Identified by match to protein family HMM PF00694; Belongs to the LeuD family. (174 aa) |
| | AEF81922.1 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330; match to protein family HMM TIGR01343; match to protein family HMM TIGR02086; Belongs to the aconitase/IPM isomerase family. (427 aa) |
| | AEF80550.1 | Ribose-5-phosphate isomerase B (Phosphoriboisomerase B); Identified by match to protein family HMM PF02502. (204 aa) |
| | metK_1 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (389 aa) |
| | gltA | Glutamate synthase (NADPH), homotetrameric; Identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01316. (500 aa) |
| | AEF81474.1 | Transaldolase; Identified by match to protein family HMM PF00923. (364 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (187 aa) |
| | mtnN | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (236 aa) |
| | luxS | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (158 aa) |
| | AEF81863.1 | Methionine synthase; Identified by match to protein family HMM PF02574. (430 aa) |
| | thrC_2 | Threonine synthase; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR00260. (434 aa) |
| | AEF81902.1 | Transketolase; Identified by match to protein family HMM PF00456. (278 aa) |
| | AEF82056.1 | Transketolase; Identified by match to protein family HMM PF02779; match to protein family HMM PF02780. (316 aa) |
| | thrC_1 | Threonine synthase; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR00260. (441 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (286 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (263 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa) |
| | serC | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (367 aa) |
| | AEF80762.1 | Phosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (392 aa) |
| | rpe_2 | Ribulose-phosphate 3-epimerase; Identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163. (223 aa) |
| | AEF80810.1 | Glutamine synthetase (Glutamate--ammonia ligase) (GS); Identified by match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (713 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (306 aa) |
| | ilvE | Branched-chain-amino-acid transaminase; Identified by match to protein family HMM PF01063; match to protein family HMM TIGR01123; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (362 aa) |
| | ilvN | Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. (176 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (512 aa) |
| | AEF80811.1 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM PF08502; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. (533 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (383 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. (552 aa) |
| | ilvB | Acetolactate synthase, large subunit, biosynthetic type; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. (583 aa) |
| | AEF83222.1 | Aminotransferase; Identified by match to protein family HMM PF00155. (408 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (370 aa) |
| | AEF82100.1 | Putative histidinol-phosphatase; Identified by match to protein family HMM PF02811; match to protein family HMM TIGR01856; Belongs to the PHP hydrolase family. HisK subfamily. (287 aa) |
| | AEF80497.1 | Putative 3-dehydroquinate dehydratase, type 1/shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01487; match to protein family HMM PF01488; match to protein family HMM PF08501. (504 aa) |
| | rpiA | Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (238 aa) |
| | AEF80164.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF00285. (446 aa) |
| | AEF80707.1 | Cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. (382 aa) |
| | AEF81138.1 | 2-isopropylmalate synthase (Alpha-isopropylmalatesynthase) (Alpha-IPM synthetase); Identified by match to protein family HMM PF00682; Belongs to the alpha-IPM synthase/homocitrate synthase family. (521 aa) |
| | AEF81412.1 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). (284 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. (189 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (206 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | AEF81356.1 | Histidinol-phosphate transaminase; Identified by match to protein family HMM PF00155. (326 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (442 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (381 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa) |
| | AEF82109.1 | Acetylornithine transaminase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00707. (400 aa) |
| | sdaAA | L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718. (314 aa) |
| | sdaAB | L-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719. (237 aa) |
| | argG | Argininosuccinate synthase; Identified by match to protein family HMM PF00764; match to protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (422 aa) |
| | argH | Argininosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00838. (470 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase, type I; Identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (357 aa) |
| | pgk | Bifunctional PGK/TIM; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (668 aa) |
| | argA | Amino-acid N-acetyltransferase; Identified by match to protein family HMM PF00583; match to protein family HMM TIGR01890; Belongs to the acetyltransferase family. (440 aa) |
| | pfkA-2 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (368 aa) |
| | AEF81656.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF00285. (452 aa) |
| | cysK_3 | Cysteine synthase A; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139. (306 aa) |
| | pyk | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (611 aa) |
| | AEF80868.1 | Aspartate aminotransferase; Identified by match to protein family HMM PF00155. (405 aa) |
| | rpiB_2 | Ribose-5-phosphate isomerase B; Identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689; match to protein family HMM TIGR01120. (152 aa) |
